Impact of bifurcation angle and other anatomical characteristics on blood flow – A computational study of non-stented and stented coronary arteries

Beier, Susann; Ormiston, John A.; Webster, Mark; Cater, John; Norris, Stuart; Medrano-Gracia, Pau; Ac, Young; Cowan, Brett R.

doi:10.1016/j.jbiomech.2016.03.038

Cited by 50 publications

(34 citation statements)

References 38 publications

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“…This is also confirmed in this study with wider angulations (>80°) associated with hemodynamic changes when compared to narrower angulations. This is in accordance with previous reports based on realistic and patient-specific coronary models showing the direct correlation between coronary angulation and corresponding hemodynamic changes (25,26,(37)(38)(39)(40).…”

Section: A B C a B Csupporting

confidence: 93%

An investigation of correlation between left coronary bifurcation angle and hemodynamic changes in coronary stenosis by coronary computed tomography angiography-derived computational fluid dynamics

Sun

Chaichana

2017

Quant. Imaging Med. Surg.

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This study further clarifies the relationship between left coronary bifurcation angle and significant stenosis, with angulation measurement serving as a more accurate approach than coronary lumen assessment or plaque lesion length for determining significant coronary stenosis. Left coronary bifurcation angle is suggested to be incorporated into coronary artery disease (CAD) assessment when diagnosing significant CAD.

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Section: A B C a B Csupporting

confidence: 93%

An investigation of correlation between left coronary bifurcation angle and hemodynamic changes in coronary stenosis by coronary computed tomography angiography-derived computational fluid dynamics

Sun

Chaichana

2017

Quant. Imaging Med. Surg.

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“…Their analysis was based on idealized and patientspecific left coronary artery with different angulations. Their results showed that vessel shape features including tortuosity, diameter or incoming angle produce more impact than bifurcation angle on WSS distribution [36]. Further research is required to clarify the correlation between bifurcation angle and WSS changes in the left coronary artery.…”

Section: Research Articlementioning

confidence: 99%

Computational fluid dynamic analysis of calcified coronary plaques: correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments

Sun¹,

Chaichana²

2016

ica

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The purpose of this study was to determine the relationship between left coronary bifurcation angle and significant coronary stenosis with use of coronary CT angiography (CCTA)-generated computational fluid dynamics (CFD) analysis when compared to the CCTA analysis of coronary lumen stenosis with invasive coronary angiography (ICA) as the reference method. Eleven patients with calcified plaques at the left coronary artery tree who underwent CCTA and ICA examinations were included in the study. CFD simulation of left coronary models was performed to analyse hemodynamic changes including wall shear stress, wall pressure and flow velocity. The mean bifurcation angle was measured 83.3 ± 17.1° and 83.3 ± 17.0° on CCTA and ICA, respectively, with no significant difference (p=0.99). Of 15 significant stenosis at left anterior descending (LAD) and left circumflex (LCx) on CCTA, only 3 of them were confirmed to be > 50% stenosis on ICA. Wall shear stress was noted to increase in the LAD and LCx models with significant stenosis and wider angulation (> 80°), but remained no change in most of the other coronary models with no significant stenosis and narrower angulation. Wall pressured was decreased at the significant stenotic lesions, while flow velocity was increased with flow turbulence at the post-stenotic sites. This study further clarifies the direct correlation between left coronary bifurcation angle and significant stenosis, with angulation measurement being more accurate than lumen assessment for diagnosing significant stenosis.

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“…All the procedural steps followed the standard clinical protocol ( Figure 1 As suggested by Beier et al [24], in PCI for bifurcation lesion, the bifurcation angle and calcification had major impact on stent performance. Moreover, the lack or excess of the amount of metal layers on the carina has been proven to cause stent restenosis and thrombosis, respectively [25].…”

Section: Bench Simulationmentioning

confidence: 99%

Complex coronary bifurcation treatment by a novel stenting technique: Bench test, fluid dynamic study and clinical outcomes

Rigatelli

Zuin

Dell’Avvocata

et al. 2018

Cathet Cardio Intervent

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Impact of bifurcation angle and other anatomical characteristics on blood flow – A computational study of non-stented and stented coronary arteries

Cited by 50 publications

References 38 publications

An investigation of correlation between left coronary bifurcation angle and hemodynamic changes in coronary stenosis by coronary computed tomography angiography-derived computational fluid dynamics

An investigation of correlation between left coronary bifurcation angle and hemodynamic changes in coronary stenosis by coronary computed tomography angiography-derived computational fluid dynamics

Computational fluid dynamic analysis of calcified coronary plaques: correlation between hemodynamic changes and cardiac image analysis based on left coronary bifurcation angle and lumen assessments

Complex coronary bifurcation treatment by a novel stenting technique: Bench test, fluid dynamic study and clinical outcomes

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