Impact of basal diet on dextran sodium sulphate (DSS)-induced colitis in rats

Boussenna, Ahlem; Goncalves-Mendès, Nicolas; Joubert‐Zakeyh, Juliette; Pereira, Bruno; Fraisse, Didier; Vasson, Marie‐Paule; Texier, Odile; Felgines, Catherine

doi:10.1007/s00394-014-0800-2

Cited by 14 publications

(19 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, T and natural killer cells are mediated by the IL-12 cytokine, which in turn fuels TNF-α secretion ( 49 ). As reported previously, pro-inflammatory cytokine levels (TNF-α, IL-12, and IL-1β) in colonic tissues were elevated significantly by DSS exposure ( 50 , 51 ). These cytokines have been inhibited by Lactobacillus species, endowing the latter with reduction of pro-inflammatory properties ( 52 – 54 ).…”

Section: Discussionsupporting

confidence: 82%

Lactobacillus plantarum L15 Alleviates Colitis by Inhibiting LPS-Mediated NF-κB Activation and Ameliorates DSS-Induced Gut Microbiota Dysbiosis

Peng

Guo

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

Previous studies have suggested that the Lactobacillus plantarum bacteria strain could be effective in ulcerative colitis (UC) management. However, its effects are strain-specific and the related mechanisms for its attenuating effects on UC remain unclear. This study aimed to elucidate the underlying mechanisms for the protective effect of L. plantarum on UC. Firstly, 15 L. plantarum strains were screened for potential probiotic characteristics with good tolerance to simulated human gastrointestinal transit and adhesion. Secondly, the inflammatory response of selected strains to the Caco-2 cells induced by lipopolysaccharide (LPS) was measured. Finally, an in vivo mouse model induced by dextran sulfate sodium (DSS) was used to assess the beneficial effects and likely action mechanisms the successfully screened in vitro strain, L. plantarum L15. In vitro results showed that L. plantarum L15 possessed the highest gastrointestinal transit tolerance, adhesion and reduction of pro-inflammatory abilities compared to the other screened strains. In vivo , high dose of L. plantarum L15 supplementation increased the body weight, colon length and anti-inflammatory cytokine production. Pro-inflammatory cytokine production, disease activity index (DAI) levels and myeloperoxidase (MPO) parameters decreased using this strain. In addition, L. plantarum L15 alleviated the histopathological changes in colon, modulated the gut microbiota, and decreased LPS secretion. The activities of this strain down-regulated the expression of TLR4 and MyD88 genes as well as genes associated with NF-κB signaling pathway. Our findings present L. plantarum L15 as a new probiotic, with promising application for UC management.

show abstract

Section: Discussionsupporting

confidence: 82%

Lactobacillus plantarum L15 Alleviates Colitis by Inhibiting LPS-Mediated NF-κB Activation and Ameliorates DSS-Induced Gut Microbiota Dysbiosis

Peng

Guo

et al. 2020

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…Cytokines are recognized to play a crucial role in the immunopathogenesis of IBD . DSS significantly increased the levels of pro‐inflammatory cytokines such as IL‐1 β , IL1‐ α , IFN‐ γ and IL‐6 in colonic tissue, as reported previously . GPE consumption greatly prevented the rise of these cytokines and decreased the TNF‐ α level.…”

Section: Discussionsupporting

confidence: 79%

“…Colonic MMP‐9 levels have been closely correlated with colonic damage . Here, DSS stimulated MMP9 mRNA expression, as reported . Furthermore, all GPEs prevented this up‐regulation of MMP9 expression, which may have helped attenuate colitis symptoms and tissue alterations.…”

Section: Discussionsupporting

confidence: 79%

Polyphenol‐rich grape pomace extracts protect against dextran sulfate sodium‐induced colitis in rats

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…In comparison to the diverse microbiota of mice reared on conventional grain-based chow, the immune phenotype of the microbiome of mice fed purified, phytochemical-free diets (often termed AHR ligand-free diets) is changed in a manner similar to that seen in AHR-deficient animals [ 28 , 112 , 113 ]. Like the AHR-deficient mice, animals fed purified, phytochemical-free diets exhibit enhanced susceptibility to severe colitis [ 113 , 114 , 115 ]. Furthermore, there are numerous reports that phytochemicals—including berberine [ 116 ], curcumin [ 117 ], galangin [ 118 ], resveratrol [ 119 ], and rutin [ 120 ]—can prevent microbial dysbiosis and stimulate colonization of the gut by beneficial anaerobic bacteria (reviewed by [ 121 , 122 ]).…”

Section: The Mechanism(s) By Which Ficz Il-22 and Butyrate Promotmentioning

confidence: 99%

How the AHR Became Important in Intestinal Homeostasis—A Diurnal FICZ/AHR/CYP1A1 Feedback Controls Both Immunity and Immunopathology

Rannug

2020

IJMS

View full text Add to dashboard Cite

Ever since the 1970s, when profound immunosuppression caused by exogenous dioxin-like compounds was first observed, the involvement of the aryl hydrocarbon receptor (AHR) in immunomodulation has been the focus of considerable research interest. Today it is established that activation of this receptor by its high-affinity endogenous ligand, 6-formylindolo[3,2-b]carbazole (FICZ), plays important physiological roles in maintaining epithelial barriers. In the gut lumen, the small amounts of FICZ that are produced from L-tryptophan by microbes are normally degraded rapidly by the inducible cytochrome P4501A1 (CYP1A1) enzyme. This review describes how when the metabolic clearance of FICZ is attenuated by inhibition of CYP1A1, this compound passes through the intestinal epithelium to immune cells in the lamina propria. FICZ, the level of which is thus modulated by this autoregulatory loop involving FICZ itself, the AHR and CYP1A1, plays a central role in maintaining gut homeostasis by potently up-regulating the expression of interleukin 22 (IL-22) by group 3 innate lymphoid cells (ILC3s). IL-22 stimulates various epithelial cells to produce antimicrobial peptides and mucus, thereby both strengthening the epithelial barrier against pathogenic microbes and promoting colonization by beneficial bacteria. Dietary phytochemicals stimulate this process by inhibiting CYP1A1 and causing changes in the composition of the intestinal microbiota. The activity of CYP1A1 can be increased by other microbial products, including the short-chain fatty acids, thereby accelerating clearance of FICZ. In particular, butyrate enhances both the level of the AHR and CYP1A1 activity by stimulating histone acetylation, a process involved in the daily cycle of the FICZ/AHR/CYP1A1 feedback loop. It is now of key interest to examine the potential involvement of FICZ, a major physiological activator of the AHR, in inflammatory disorders and autoimmunity.

show abstract

Impact of basal diet on dextran sodium sulphate (DSS)-induced colitis in rats

Abstract: These results show that a purified diet promotes the onset of a more severe induced colitis than a non-purified one, highlighting the influence of basal diet in colitis development.

Cited by 14 publications

References 42 publications

Lactobacillus plantarum L15 Alleviates Colitis by Inhibiting LPS-Mediated NF-κB Activation and Ameliorates DSS-Induced Gut Microbiota Dysbiosis

Lactobacillus plantarum L15 Alleviates Colitis by Inhibiting LPS-Mediated NF-κB Activation and Ameliorates DSS-Induced Gut Microbiota Dysbiosis

Polyphenol‐rich grape pomace extracts protect against dextran sulfate sodium‐induced colitis in rats

How the AHR Became Important in Intestinal Homeostasis—A Diurnal FICZ/AHR/CYP1A1 Feedback Controls Both Immunity and Immunopathology

Contact Info

Product

Resources

About