Impact of Atrial Fibrillation on In-hospital Outcomes and Healthcare Resource Utilization of Women With Peripartum Cardiomyopathy: A Study From National Inpatient Sample

Shah, Kashyap; Ferraro, Bruce; Krinock, Matthew; Modi, Vivek; Pandya, Maharshi; Thyagaturu, Harshith; Cutitta, Christopher

doi:10.1016/j.cpcardiol.2022.101425

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…Studies have shown atrial fibrillation to also be associated with increased mortality in patients with heart failure, regardless of whether it develops before or after heart failure [ 18 ]. In addition, the association between atrial fibrillation and outcomes in PPCM has been studied before and showed that atrial fibrillation was associated with increased mortality [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

The Impact of Coronary Artery Disease on Outcomes in Patients With Peripartum Cardiomyopathy

Elkattawy,

Phansalkar,

Elkattawy

et al. 2024

Cureus

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Introduction The purpose of this study was to determine the prevalence of coronary artery disease (CAD) among patients admitted with peripartum cardiomyopathy (PPCM) as well as to analyze the independent association of CAD with in-hospital outcomes among PPCM patients. Methods Data were obtained from the National Inpatient Sample from January 2016 to December 2019. We assessed the independent association of CAD with outcomes in patients admitted with PPCM. Predictors of mortality in patients admitted with PPCM were also analyzed. Results There was a total of 4,730 patients with PPCM, 146 of whom had CAD (3.1%). Multivariate analysis demonstrated that CAD in patients with PPCM was independently associated with several outcomes, and, among them, ST-segment elevation myocardial infarction (STEMI) (adjusted odds ratio (aOR): 58.457, 95% CI: 5.403-632.504, p= 0.001) was positively associated with CAD. CAD was found to be protective against preeclampsia (aOR: 0.351, 95% CI: 0.126-0.979, p = 0.045). Predictors of in-hospital mortality for patients with PPCM include cardiogenic shock (aOR: 12.818, 95% CI: 7.332-22.411, p = 0.001), non-ST elevation myocardial infarction (NSTEMI) (OR: 3.429, 95% CI: 1.43-8.22, p = 0.006), chronic kidney disease (OR: 2.851, 95% CI: 1.495-5.435, p = 0.001), and atrial fibrillation (OR: 2.326, 95% CI: 1.145-4.723, p = 0.020). Conclusion In a large cohort of patients admitted with PPCM, we found the prevalence of CAD to be 3.1%. CAD was associated with several adverse outcomes, including STEMI, but protective against preeclampsia.

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Section: Discussionmentioning

confidence: 99%

The Impact of Coronary Artery Disease on Outcomes in Patients With Peripartum Cardiomyopathy

Elkattawy,

Phansalkar,

Elkattawy

et al. 2024

Cureus

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Pregnancy-Related Complications and Incidence of Atrial Fibrillation: A Systematic Review

Bahhawi

Aqeeli

Harrison

et al. 2023

JCM

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Pregnancy-related complications are associated with a higher risk of various incident cardiovascular diseases, but their specific potential relationship with incident atrial fibrillation (AF) is less clear. This systematic review summarises the available evidence from observational studies which have examined associations between pregnancy-related complications and the risk of AF. MEDLINE and EMBASE (Ovid) were searched for studies between 1990 to 10 February 2022. Pregnancy-related complications examined included hypertensive disorders of pregnancy (HDP), gestational diabetes, placental abruption, preterm birth, small-for-gestational-age and stillbirth. Study selection, data extraction and quality assessment were completed independently by two reviewers. Narrative synthesis was used to evaluate the results of the included studies. Nine observational studies were included, with eight eligible for narrative synthesis. Sample sizes ranged from 1839 to 2,359,386. Median follow-up ranged from 2 to 36 years. Six studies reported that pregnancy-related complications were associated with a significantly increased risk of incident AF. Hazard ratios (HRs) (95% confidence intervals) for the four studies that evaluated HDP ranged from 1.1 (0.8–1.6) to 1.9 (1.4–2.7). For the four studies that evaluated pre-eclampsia, HRs ranged from 1.2 (0.9–1.6) to 1.9 (1.7–2.2). Current evidence from observational studies suggests pregnancy-related complications are associated with a significantly higher risk of incident AF. However, only a small number of studies examining each pregnancy-related complication were identified, and considerable statistical heterogeneity was observed. Further large-scale prospective studies are required to confirm the association between pregnancy-related complications and incident AF.

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Impact of Atrial Fibrillation on In-hospital Outcomes and Healthcare Resource Utilization of Women With Peripartum Cardiomyopathy: A Study From National Inpatient Sample

Cited by 2 publications

References 15 publications

The Impact of Coronary Artery Disease on Outcomes in Patients With Peripartum Cardiomyopathy

The Impact of Coronary Artery Disease on Outcomes in Patients With Peripartum Cardiomyopathy

Pregnancy-Related Complications and Incidence of Atrial Fibrillation: A Systematic Review

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