Impact of atrial fibrillation on frailty and functionality in older adults

Koca, Meltem; Yavuz, Burcu Balam; Doğrul, Rana Tuna; Çalışkan, Hatice; Ayçiçek, Gözde Şengül; Özsürekçi, Cemile; Balcı, Cafer; Eşme, Mert; Ünsal, Pelin; Halil, Meltem; Cankurtaran, Mustafa

doi:10.1007/s11845-020-02190-x

Cited by 18 publications

(19 citation statements)

References 36 publications

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“…However, whether such causal association extends to other CVD outcomes remains unknown. Notably, several observational studies showed that walking pace was significantly associated with the risk of atrial fibrillation (AF) ( Mozaffarian et al, 2008 ; Koca et al, 2020 ) and heart failure (HF) ( Saevereid et al, 2014 ) as well as stroke ( Quan et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Self-Reported Walking Pace and Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study

Chen

Sun

et al. 2022

Front. Genet.

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Background: In observational studies, the self-reported walking pace has been associated with the risk of cardiovascular diseases (CVD). However, whether those associations indicate causal links remains unclear. We performed two-sample Mendelian randomization (MR) analyses to evaluate the causal effect of walking pace on several CVD outcomes, including atrial fibrillation (AF), heart failure (HF), any stroke, ischemic stroke (IS), and IS subtypes.Methods: Genetic variants associated with self-reported walking pace were selected as instrumental variables (IVs) from the latest genome-wide association studies (GWAS). Summary-level data for outcomes were obtained from the corresponding GWAS and the FinnGen consortium. The random-effects inverse variance weighted (IVW) method was used as the main MR analysis, supplemented by replication analyses using data from the FinnGen. To explore the effect of pleiotropy due to adiposity-related traits, we further conducted MR analyses by excluding the adiposity-related IVs and regression-based multivariable MR adjusting for body mass index (BMI).Results: The MR results indicated significant inverse associations of self-reported walking pace with risks of AF [odds ratio (OR), 0.577; 95% confidence interval (CI), 0.442, 0.755; p = 5.87 × 10−5], HF (OR, 0.307; 95% CI, 0.229, 0.413; p = 5.31 × 10−15), any stroke (OR, 0.540; 95% CI, 0.388, 0.752; p = 2.63 × 10−4) and IS (OR, 0.604; 95% CI, 0.427, 0.853; p = 0.004) and suggestive inverse association of self-reported walking pace with cardioembolic stroke (CES) (OR, 0.492; 95% CI, 0.259, 0.934; p = 0.030). Similar results were replicated in the FinnGen consortium and persisted in the meta-analysis. However, there was no causality between walking pace and large artery stroke (OR, 0.676; 95% CI, 0.319, 1.434; p = 0.308) or small vessel stroke (OR, 0.603; 95% CI, 0.270, 1.349; p = 0.218). When excluding adiposity-related IVs and adjusting for BMI, the associations for HF and any stroke did not change substantially, whereas the associations for AF, IS, and CES were weakened.Conclusion: Our findings suggested that genetically predicted increasing walking pace exerted beneficial effects on AF, HF, any stroke, IS, and CES. Adiposity might partially mediate the effect of walking pace on AF, IS, and CES.

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Section: Introductionmentioning

confidence: 99%

Self-Reported Walking Pace and Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study

Chen

Sun

et al. 2022

Front. Genet.

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“…Studies showed that patients with atrial fibrillation were more dependent on instrumental activities of daily living, falling more frequently, and frailty was correlated with symptom severity score [13]. In our study, the median age was over 65 in both home healthcare services and outpatient clinics.…”

Section: Discussionmentioning

confidence: 45%

Warfarin treatment: home health services versus outpatient clinics

Ünsal¹

2021

Erciyes Med J

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“…Based upon both age and BNP, this shows that our sample consisted of individuals with increasing clinical concern for heart failure and frailty. Koca et al (2020) found that severity of atrial fibrillation, based on symptoms, is associated with both frailty and elevated BNP in older adults. This is consistent with the findings in our study, with half of our patients having a diagnosis of atrial fibrillation ( Table 2 ).…”

Section: Discussionmentioning

confidence: 97%

Cardiovascular Health in Individuals with Exceptional Longevity Residing in Arkansas

Mize¹,

Duke²,

Pangle³

et al. 2021

Gerontology and Geriatric Medicine

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Cardiovascular disease is a common comorbidity associated with an aging population. However, there is a unique group of individuals whose age-defying qualities are still being investigated. This retrospective chart review analyzed various cardiac and metabolic health parameters to characterize the prevalence of heart failure and metabolic derangements in individuals aged 90 years old or older in central Arkansas. Only 236 of the 291 patients in our study cohort had blood pressures recorded. Of these, 50% had systolic blood pressures ≥140 mmHg. Additionally, 77% had pulse pressures ≥50 mmHg. Of the 96 patients with BNP data, 44% had values ≥300 pg/mL. There was a slight positive correlation between aging and HDL cholesterol, while there was a negative correlation between aging and both total cholesterol and LDL cholesterol. A majority of our patients had both elevated systolic blood pressures and elevated pulse pressures. A majority also had high BNP values, indicative of some degree of heart failure. Additionally, atrial fibrillation was a common arrhythmia identified on EKG. However, these oldest of the old patients had fewer documented metabolic derangements. These findings lay important groundwork for further investigation into lifestyle and genetic components that allow them to live exceptionally long with such comorbidities.

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Impact of atrial fibrillation on frailty and functionality in older adults

Cited by 18 publications

References 36 publications

Self-Reported Walking Pace and Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study

Self-Reported Walking Pace and Risk of Cardiovascular Diseases: A Two-Sample Mendelian Randomization Study

Warfarin treatment: home health services versus outpatient clinics

Cardiovascular Health in Individuals with Exceptional Longevity Residing in Arkansas

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