Impact of atomization technique on the stability and transport efficiency of nebulized liposomes harboring different surface characteristics

Lehofer, Bernhard; Bloder, Florian; Jain, Pritesh; Marsh, Leigh M.; Leitinger, Gerd; Olschewski, Horst; Leber, Regina; Olschewski, Andrea; Ruth, Peter

doi:10.1016/j.ejpb.2014.10.009

Cited by 31 publications

(27 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ultrasonic devices are well known for not being appropriate to deliver microparticulate dispersed dosage forms, such as budesonide suspensions, and MLV liposomes . An ultrasonic nebulizer has shown to selectively aerosolize the continuous aqueous phase of a latex microsphere suspension while the microspheres were left in the reservoir .…”

Section: Established Nebulizersmentioning

confidence: 99%

“…Active devices have been shown to be capable of delivering liposomal formulations of water‐soluble drugs as well, demonstrating a superior performance when compared to air‐jet and ultrasonic systems (greater physical stability and output rate) . Nevertheless, comparable performance of these three types of nebulizers was demonstrated when nebulizing ultradeformable liposomes, which are stress‐responsive vesicles containing Tween‐80 and ethanol .…”

Section: Established Nebulizersmentioning

confidence: 99%

“…[23] Ultrasonic devices are well known for not being appropriate to deliver microparticulate dispersed dosage forms, such as budesonide suspensions, and MLV liposomes. [12,51,66,67] An ultrasonic nebulizer has shown to selectively aerosolize the continuous aqueous phase of a latex microsphere suspension while the microspheres were left in the reservoir. [43] Radiolabelled solid lipid nanoparticles, however, have been effectively delivered to the lungs using this aerosol generation mechanism to study lymphatic uptake.…”

Section: Ultrasonic Nebulizersmentioning

confidence: 99%

See 2 more Smart Citations

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives In this review paper, we explore the interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations for several types of devices, namely jet, ultrasonic and vibrating-mesh nebulizers; colliding and extruded jets; electrohydrodynamic mechanism; surface acoustic wave microfluidic atomization; and capillary aerosol generation. Key findings Nebulization is the transformation of bulk liquids into droplets. For inhalation therapy, nebulizers are widely used to aerosolize aqueous systems, such as solutions and suspensions. The interaction between the functioning mechanism of different nebulizers and the physicochemical properties of the formulations plays a significant role in the performance of aerosol generation appropriate for pulmonary delivery. Certain types of nebulizers have consistently presented temperature increase during the nebulization event. Therefore, careful consideration should be given when evaluating thermo-labile drugs, such as protein therapeutics. We also present the general approaches for characterization of nebulizer formulations. Summary In conclusion, the interplay between the dosage form (i.e. aqueous systems) and the specific type of device for aerosol generation determines the effectiveness of drug delivery in nebulization therapies, thus requiring extensive understanding and characterization.

show abstract

Section: Established Nebulizersmentioning

confidence: 99%

Section: Established Nebulizersmentioning

confidence: 99%

Section: Ultrasonic Nebulizersmentioning

confidence: 99%

See 1 more Smart Citation

The function and performance of aqueous aerosol devices for inhalation therapy

Carvalho

McConville

2016

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

“…Polymeric systems typically exhibit high stability during nebulization and storage, induce minimal toxicity, and have easily tailored surface properties and degradation rates, but their small size allows for easy penetration into systemic circulation, reducing retention in the lungs (Dailey et al, ; Fiegel, Fu, & Hanes, ; Mura et al, ; Rodrigues et al, ; Ryan et al, ). Lipid‐based systems are commonly amphiphilic in nature, which allows for incorporation of both hydrophilic and hydrophobic drugs in one particle, and are composed of biocompatible lipids (closely mimicking components of the lung surface lining), thereby limiting their toxicity and prolonging their retention in the lung (Cipolla, Shekunov, Blanchard, & Hickey, ; Cryan, Devocelle, Moran, Hickey, & Kelly, ; Èller, Èder, & Gohla, ; Haque et al, ; Lehofer et al, ; Nassimi et al, ; Weber, Zimmer, & Pardeike, ). However, lipid‐based systems (for example, liposomes) have been found in some cases to suffer from burst release kinetics and instability during nebulization (Taylor, Taylor, Kellaway, & Stevens, ).…”

Section: Introductionmentioning

confidence: 99%

Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases

Anderson

Grimmett

Domalewski

et al. 2019

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

Respiratory illnesses are prevalent around the world, and inhalation‐based therapies provide an attractive, noninvasive means of directly delivering therapeutic agents to their site of action to improve treatment efficacy and limit adverse systemic side effects. Recent trends in medicine and nanoscience have prompted the development of inhalable nanomedicines to further enhance effectiveness, patient compliance, and quality of life for people suffering from lung cancer, chronic pulmonary diseases, and tuberculosis. Herein, we discuss recent advancements in the development of inhalable nanomaterial‐based drug delivery systems and analyze several representative systems to illustrate their key design principles that can translate to improved therapeutic efficacy for prevalent respiratory diseases. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Respiratory Disease

show abstract

“…The shearing provided during nebulization to convert the aqueous liposome dispersions into aerosol droplets may exert physical stress, causing drug leakage or changes in liposome morphology [28]. Lehofer et al [29] investigated the impact of atomization techniques on the stability and transport efficiency of liposomes showing different surface characteristics. The authors found that conventional liposomes were the most stable, while polymer-coated and positively charged liposomes were more prone to aggregation and drug leakage.…”

Section: Introductionmentioning

confidence: 99%

Sildenafil Citrate Liposomes for Pulmonary Delivery by Ultrasonic Nebulization

et al. 2018

View full text Add to dashboard Cite

Technological advances in lipid vesicles facilitate optimization of their properties to achieve therapeutic goals and promote alternative drug administration routes. Sildenafil citrate (SC) is orally administered for the treatment of pulmonary hypertension, but local release would be advantageous in terms of efficacy and safety. In the present study, liposomes from egg phosphatidylcholine and cholesterol loaded with SC, with and without d-α-tocopheryl polyethylene glycol 1000 succinate (Vit E TPGS), were prepared by sonication of the components. A transmembrane pH gradient was applied for active loading of liposomes, and the size, zeta potential, and entrapment efficiency (EE%) were determined. The liposomes were lyophilized and then nebulized. The nebulized samples were collected and the EE% was determined. The transmembrane pH gradient produced a significant increase in the EE% (from 17.68 ± 4.25% to 89.77 ± 7.64%) and, after lyophilization, the EE% remained the same as that of the originals, but the size and zeta potential were modified. EE% of liposomes decreased upon nebulization, particularly for those with Vit E TPGS. Thus, the additives used for lyoprotection reduced the impact of nebulization. Additional studies are essential, but according to these results, SC-loaded liposomes can be considered as suitable and safe carriers for the local release of sildenafil in the pulmonary system.

show abstract

Impact of atomization technique on the stability and transport efficiency of nebulized liposomes harboring different surface characteristics

Cited by 31 publications

References 44 publications

The function and performance of aqueous aerosol devices for inhalation therapy

The function and performance of aqueous aerosol devices for inhalation therapy

Inhalable nanotherapeutics to improve treatment efficacy for common lung diseases

Sildenafil Citrate Liposomes for Pulmonary Delivery by Ultrasonic Nebulization

Contact Info

Product

Resources

About