This study analyzed the inter-annual variability in solar radiation at Port Harcourt and Calabar, aiming at improving knowledge of solar resources. For the investigation, monthly mean global solar radiation data for fifteen years (2000-2014) was collected from Nigerian Meteorological Agency (NIMET), and the monthly mean extraterrestrial solar radiation was determined using globally recognized standard relation. The clearness index parameter was employed for characterizing the spatial variability of solar radiation for Calabar and Port Harcourt. The statistics of the monthly mean solar radiation deviations of Port Harcourt and Calabar was tested using the Kolmogorov-Smirnov method. The test results showed that they are normally distributed random variables. Furthermore, the analysis of sequential properties showed that the coefficients of the auto-correlation with lag 1 are significant for both stations. The autocorrelation coefficients with lag 1, though usually not significant, are negative for both stations. The auto regression lag 1 (AR-1) is the recommended procedure (model equation) for generating monthly solar radiation synthetic time series, with auto-correlation coefficients varying from 0.30 to 0.47 for both stations in the South-South of Nigeria.