Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies

Ricciarelli, Elisabetta; Bruna, I.; Verdú, Vicente; Torrelló, M. J.; Herrer, R.; Gris, Jean‐Christophe; Arroyo, Gemma; Perez-Millan, Federico; Río, F. Del; Sánchez, Manuel Fernández; Cabello, Yolanda; Ardoy, Manuel; Fernández-Shaw, S.

doi:10.1007/s10815-013-0023-0

Cited by 7 publications

(6 citation statements)

References 37 publications

(53 reference statements)

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“…This study found an incidence of 12% for prematurity in singleton pregnancies, very similar to the rate reported for other cohorts of assisted reproductive technology babies (Levi Setti et al, 2016;Ricciarelli et al, 2013). Among multiple pregnancies, 45% had premature delivery, which is consistent with the 42 − 68% rate reported by other European countries (Ricciarelli et al, 2013).…”

Section: Discussionsupporting

confidence: 90%

“…The percentage of stillbirth observed was similar to that reported for assisted reproductive technology pregnancy (Bonduelle et al, 2002;Koudstaal et al, 2000;Ricciarelli et al, 2013;Westergaard et al, 1999). It seems to be slightly, but not significantly, higher than the observed in natural conceptions (Fedder et al, 2013).…”

Section: Discussionsupporting

confidence: 84%

“…The most important consideration in all IVF procedures is indeed patients' safety, both for the women undergoing the procedures and for any potential resulting offspring. Reassuringly, gestational age at delivery in single pregnancies and in pregnancies of twins after PF-ICSI were similar to those observed in two cohorts of assisted reproductive technology pregnancies from Italy and Spain (Levi Setti et al, 2016;Ricciarelli et al, 2013), the comparison with which could include variability due to geographical heterogeneity. The rate of biochemical pregnancies was in line with that reported for the previously published dataset to which we have referred (Bonduelle et al, 2002).…”

Section: Discussionsupporting

confidence: 81%

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Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa

Navas

Paffoni

Intra

et al. 2017

Reproductive BioMedicine Online

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Pentoxifylline (PF) represents an effective tool in stimulating motility and identifying viable spermatozoa in intracytoplasmic sperm injection (ICSI) patients presenting exclusively with immotile spermatozoa. However, its use is not universally accepted for its possible detrimental effects on oocytes, embryos or newborns. To evaluate whether PF use may affect obstetrical/neo-natal outcomes, 102 patients achieving a clinical pregnancy after a PF-ICSI in four IVF units in Spain and Italy were followed up after delivery. Neo-natal malformations were classified according to the World Health Organization International Classification of Diseases (ICD-10, range Q00-Q99). Malformation rate was compared with data published by other groups regarding children conceived by conventional IVF or ICSI reporting a 5.3% and 4.4% frequency of ICD-10 codes, respectively. Of 134 clinical pregnancies, 122 babies (82 singletons and 40 twins) were registered. Among singletons, the rates of low birthweight (≤2500 g) and preterm birth (<37 weeks) were 6.1% and12%, respectively. Regarding malformation rate per live births, 4/122 (3.3%, 95% confidence interval: 0.9-8.2%) babies with ICD-10 malformations were recorded. This is the first report on neo-natal outcomes deriving from PF-ICSI. Although based on a limited cohort, results do not suggest an increase of adverse outcomes, including malformation rates, following this procedure.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 84%

Section: Discussionsupporting

confidence: 81%

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Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa

Navas

Paffoni

Intra

et al. 2017

Reproductive BioMedicine Online

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“…Thirty‐four studies met inclusion criteria (Figure 1). 23–54 There were 33 cohort studies and one case‐control study. No randomized trials were identified and no isolated abstracts or unpublished studies were identified that met eligibility criteria.…”

Section: Resultsmentioning

confidence: 99%

Risk of stillbirth in singleton gestations following in vitro methods of conception: a systematic review and meta‐analysis

Wong

Carson

Crane

2021

BJOG

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Background In vitro methods of conception are associated with adverse perinatal outcomes. It is unclear if the risk of stillbirth is increased also. Objective This systematic review and meta‐analysis aimed to estimate the risk of stillbirth in singleton gestations following in vitro methods of conception compared to non‐in vitro conceptions. Search strategy A comprehensive search in PubMed, Embase, CINAHL, and Cochrane Library was undertaken from database inception to February 2021, with backward citation tracking. Selection criteria Eligible studies included randomized controlled trials, cohort studies, or case‐control studies that assessed stillbirth following in vitro fertilisation and/or intracytoplasmic sperm injection in comparison to non‐in vitro methods of conception, including spontaneous conceptions, intrauterine insemination, and ovarian stimulation. Data collection and analysis The Newcastle‐Ottawa Scale was used to assess risk of bias. A summary odds ratio (OR) for stillbirth following in vitro methods of conception compared to non‐in vitro methods was calculated using a random‐effects model for meta‐analysis. Main results Thirty‐three cohort studies met inclusion criteria. There was an increased risk of stillbirth with in vitro methods: OR 1.41 (95% CI 1.20–1.65); however, the crude baseline risk of stillbirth was low (4.44/1000 total births). Subgroup analysis did not demonstrate an increased risk when in vitro methods were compared to conception without in vitro methods in the context of subfertility. Conclusions Compared to non‐in vitro conceptions, in vitro conceptions have an increased risk of stillbirth. However, there is insufficient evidence to demonstrate whether this risk is associated with in vitro techniques or underlying subfertility. Tweetable abstract This meta‐analysis found an increased risk of stillbirth in singletons from in vitro methods of conception.

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“…Most newborns conceived through ART are healthy, but these have also been associated with higher rates of adverse obstetric and perinatal outcomes [7][8][9]. Concern about the safety of reproductive techniques and their effect on foetal/ maternal well-being is growing [10].…”

Section: Introductionmentioning

confidence: 99%

Obstetric and perinatal complications associated with assisted reproductive treatment in Spain

Ballesta‐Castillejos

Gómez‐Salgado

Rodríguez‐Almagro

et al. 2019

J Assist Reprod Genet

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Background Although most newborns conceived through assisted reproductive treatments are healthy, there are concerns about the safety of reproductive techniques and their effect on foetal/maternal well-being. Objective This study aims to describe the incidence of obstetric and perinatal complications in women undergoing assisted reproductive treatments in the Spanish Health System. Method This is a cross-sectional observational study aimed at women who have been mothers between 2013 and 2018 in Spain. The data was collected through an online survey of 42 items that was distributed through lactation associations and postpartum support groups. In the data analysis, crude odds ratios (OR) and adjusted odds ratios (AOR) were calculated, through a multivariate analysis with binary logistic regression and multinomial logistic regression. Results Five thousand nine hundred forty-two women participated, 2.3% (139) through artificial insemination and 8.2% (486) through in vitro fertilisation (IVF) techniques. Women who underwent IVF had a higher likelihood of suffering problems during pregnancy (OR = 1.71; 95% confidence intervals (95% CI), 1.37-2.13), delivery (OR = 1.43; 95% CI, 1.01-2.02), and postpartum (OR = 1.94; 95% CI, 1.40-2.69) than women with spontaneous pregnancy. No increased likelihood of neonatal problems was observed in this group except for twin pregnancy (OR = 9.17; 95% CI, 6.02-13.96) and prematurity (OR = 1.43; 95% CI, 1.01-2.02). No differences were observed between spontaneous pregnancies and those achieved by artificial insemination. Conclusions Pregnancies achieved through IVF present a higher risk of complications before, during and after delivery. However, there is no increased risk of neonatal problems except for a higher likelihood of twin pregnancy and prematurity.

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Impact of assisted reproduction treatments on Spanish newborns: report of 14,119 pregnancies

Cited by 7 publications

References 37 publications

Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa

Obstetric and neo-natal outcomes of ICSI cycles using pentoxifylline to identify viable spermatozoa in patients with immotile spermatozoa

Risk of stillbirth in singleton gestations following in vitro methods of conception: a systematic review and meta‐analysis

Obstetric and perinatal complications associated with assisted reproductive treatment in Spain

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