Impact of assisted reproduction techniques on the neuro-psycho-motor outcome of newborns: a critical appraisal

Gullo, Giuseppe; Scaglione, Marco; Cucinella, Gaspare; Perino, Antonino; Chiàntera, Vito; D’Anna, Rosario; Laganà, Antonio Simone; Buzzaccarini, Giovanni

doi:10.1080/01443615.2022.2109953

Cited by 12 publications

(9 citation statements)

References 40 publications

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“…Further randomized control trials are required to determine the impact of the different endometrial preparation protocols in endometriosis patients. Moreover, the importance of investigating the neonatal outcomes and long-term follow-up of children born from frozen embryos [ 32 , 38 ] and the psychological effects cannot be ignored [ 39 – 41 ]. Notably, there are other overlooked conditions that require the exploration of FET strategies other than endometriosis, such as the diagnosis of cancer [ 42 – 45 ] and thyroid autoimmunity [ 46 – 48 ].…”

Section: Discussionmentioning

confidence: 99%

Which endometrial preparation protocol provides better pregnancy and perinatal outcomes for endometriosis patients in frozen-thawed embryo transfer cycles? A retrospective study on 1413 patients

Guo

Fang

et al. 2023

J Ovarian Res

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Objective To determine the optimal endometrial preparation protocol for a frozen embryo transfer in patients with endometriosis. Design Retrospective cohort study. Setting Tertiary care academic medical center. Patient(s) One thousand four hundred thirteen patients with endometriosis who underwent oocyte aspiration from 2015 to 2020 and frozen embryo transfer from 2016 to 2020 and received natural cycle, hormone replacement treatment with or without GnRHa pretreatment endometrial preparation. Intervention(s) None. Main outcome measure(s) Clinical pregnancy rate, live birth rate, miscarriage rate, multiple pregnancy rate, biochemical pregnancy rate and ectopic pregnancy rate. Singleton live births were assessed for perinatal outcomes and obstetric complications. Result(s) There were no differences in clinical pregnancy outcomes or prenatal outcomes among the three commonly used endometrial preparation protocols for frozen embryo transfer cycles in patients with endometriosis. Results remained after screening variables using univariate logistic regression into multivariate logistic regression. No advantages or disadvantages were found among the three endometrial preparation protocols in patients with endometriosis. Conclusion(s) Natural cycle, hormone replacement cycle, or hormone replacement treatment with GnRHa pretreatment showed no superiority or inferiority in pregnancy and perinatal outcomes in patients with endometriosis.

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Section: Discussionmentioning

confidence: 99%

Which endometrial preparation protocol provides better pregnancy and perinatal outcomes for endometriosis patients in frozen-thawed embryo transfer cycles? A retrospective study on 1413 patients

Guo

Fang

et al. 2023

J Ovarian Res

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“…Assisted reproductive technology can be used to protect the fertility of patients with breast cancer of childbearing age, as assisted reproductive technology was not found to be associated with an increased risk of neurodevelopmental diseases or the worsening of school cognitive performance. 31 Gullo et al 32 showed that the ability to freeze embryos made better family planning possible and enabled patients to transfer embryos at an ideal time. Sometimes an inositol supplement such as D-chiro-inositol before ovarian stimulation could improve fertility outcomes.…”

Section: Discussionmentioning

confidence: 99%

Effects of self-disclosure and resilience on reproductive concern in patients of childbearing age with breast cancer: a cross-sectional survey study

Zhu

Lin

et al. 2023

BMJ Open

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ObjectivesTo assess reproductive concerns in patients of childbearing age with breast cancer and examine the relationship between self-disclosure, resilience and reproductive concerns.DesignCross-sectional survey.SettingFive tertiary first-class general hospitals in Sichuan Province, Southwest China.ParticipantsA total of 319 patients with breast cancer of reproductive age who were hospitalised in the breast oncology department participated in this study.Main outcome measuresPrimary outcomes were the relationship between resilience, self-disclosure and reproductive concerns, and mediating effect analyses. Secondary outcomes included the status of reproductive concerns.ResultsThe model accounted for 39.1% of the variance in reproductive concerns. Self-disclosure had a direct negative effect on reproductive concerns (β= −0.371, p=0.001). Resilience had a direct negative effect on reproductive concerns (β= −0.349, p=0.001) and a direct positive effect on self-disclosure (β=0.507, p=0.001). Furthermore, self-disclosure partially mediated the relation between resilience and reproductive concerns (β= −0.177; SE=0.041; 95% CI −0.261 to –0.104; p<0.050), with a bootstrap of 10 000 samples.ConclusionsThe ﬁndings suggest that self-disclosure and resilience may ease reproductive concern. Therefore, self-disclosure education and resilience-oriented interventions should be provided to patients of childbearing age with breast cancer, to reduce reproductive concerns.

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“…Letrozole is used initially for medical treatment of breast cancer, and the importance was increased since the issues of onco-fertility and fertility assistance after cancer treatment get more and more attention ( 48 ). The long-term risky evaluation to neonates and children after the artificial reproductive technologies was needed ( 49 – 52 ), and the consultation from multi-disciplinary collaboration was therefore necessary ( 53 ). Comparing with GnRHa, Letrozole also had inferior size reduction effect of leiomyomas.…”

Section: Discussionmentioning

confidence: 99%

Letrozole as premedication of high intensity focused ultrasound treatment of uterine fibroids: A retrospective observation study

Chen

Hsu²,

Huang³

et al. 2022

Front. Med.

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BackgroundNo reports on Letrozole as a pretreatment before ablation of uterine fibroid with high intensity focused ultrasound (HIFU), so a retrospective observation study was performed to evaluate the response of different pre-HIFU medication.MethodsWe collected patients with single uterine fibroid receiving HIFU ablation from January 2018 to April 2021. All enrolled patients were classified into three group: group A (no pre-HIFU medication use), group B (Pre-HIFU letrozole use), group C (pre-HIFU gonadotrophin releasing hormone analog, GnRHa). Further associated clinical data and treatment response after HIFU treatment were reviewed and evaluated.ResultsA total of 39 patients including 21, 7, and 11 in group A, B, and C were collected respectively. After pre-HIFU medication, no difference of fibroid volume was found (A: 251.4, B: 360.6, C: 409.4 cm3, p = 0.250), and GnRHa group had significantly larger volume reduction than Letrozole users (38.6% vs. 16.4%, p = 0.007). The incidence of hypoestrogenic symptoms was higher in GnRHa group than in letrozole users (27.3% vs. 0, p = 0.170). GnRHa group had more sonication time (p = 0.001), treatment duration (p = 0.002), and ablated energy (p = 0.001) than group A and B. The treatment efficiency was higher in letrozole group than that in other 2 groups (4.52 vs. 2.39 vs. 2.34 cm3/min, p = 0.050). For patients with fibroid over 10 cm in diameter, letrozole group had even better energy efficiency (p = 0.067), treatment speed (p = 0.007), treatment efficiency (p = 0.001), NPV per energy (p = 0.005), and NPV per sonication (p = 0.004) than other 2 groups.ConclusionLetrozole as a pretreatment medication before HIFU treatment might increase the energy efficiency and treatment efficiency of its ablation of uterine leiomyoma, especially for fibroid over 10 cm. Future study of larger patient number is needed to confirm our results.

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Impact of assisted reproduction techniques on the neuro-psycho-motor outcome of newborns: a critical appraisal

Cited by 12 publications

References 40 publications

Which endometrial preparation protocol provides better pregnancy and perinatal outcomes for endometriosis patients in frozen-thawed embryo transfer cycles? A retrospective study on 1413 patients

Which endometrial preparation protocol provides better pregnancy and perinatal outcomes for endometriosis patients in frozen-thawed embryo transfer cycles? A retrospective study on 1413 patients

Effects of self-disclosure and resilience on reproductive concern in patients of childbearing age with breast cancer: a cross-sectional survey study

Letrozole as premedication of high intensity focused ultrasound treatment of uterine fibroids: A retrospective observation study

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