Impact of antimicrobial resistance on the treatment of invasive pneumococcal infections

Rocha, Paulo Roberto Souza; Baleeiro, Carlos E. O.; Tunkel, Allan R.

doi:10.1007/s11908-000-0066-0

Cited by 13 publications

(7 citation statements)

References 56 publications

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“…This pathogen causes significant morbidity and mortality worldwide in both children and adults (12,21,35). Management of pneumococcal disease is also complicated by the increasing rate at which this organism is developing resistance to multiple classes of antimicrobial agents on a global scale (3,25).…”

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confidence: 99%

Immunization with Polyamine Transport Protein PotD Protects Mice against Systemic Infection with Streptococcus pneumoniae

Shah

Swiatlo

2006

Infect Immun

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The human pathogen Streptococcus pneumoniae contains genes for a putative polyamine ABC transporter which are organized in an operon and designated potABCD. Polyamine transport protein D (PotD) is an extracellular protein which binds polyamines and possibly other structurally related molecules. PotD has been shown to contribute to virulence in both a murine sepsis model and a pneumonia model with capsular type 3 pneumococci. The protective efficacy of recombinant PotD was evaluated by active immunization and intravenous challenge with capsular type 3 pneumococci in CBA/N mice. Immunized mice had 91.7% survival following lethal pneumococcal challenge, compared with 100% mortality in the control group. Immunized animals had high-titer anti-PotD antibodies following three immunizations with alum. Protection in a sepsis model was also seen after passive administration of rabbit antiserum raised against PotD (P < 0.004). These results suggest that antibodies to PotD confer protection against invasive pneumococcal disease and that this protein should be studied further as a potential vaccine candidate for protection against invasive pneumococcal infections.

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confidence: 99%

Immunization with Polyamine Transport Protein PotD Protects Mice against Systemic Infection with Streptococcus pneumoniae

Shah

Swiatlo

2006

Infect Immun

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“…Current increasing usage of the clinical antibacterial drugs forces antibiotic resistance to occur in both pathogenic and zoonotic bacteria in animals [19]. Previous research showed that the appearance of antibiotics resistant strains can make treatment of bacterial infections more di cult, which may lead to an overall increase in transmission, morbidity and mortality [20,21]. These results suggest that effective treatment should be based on the results of antimicrobial susceptibility tests and clinical e cacy in the control of bacterial infections in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Characterization of Uropathogenic Escherichia coli (UPEC) from Red Panda (Ailurus fulgens)

Liu

Yue

et al. 2020

Preprint

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BackgroundDisease prevention and control is a significant part in the ex-situ conservation of the endangered red panda (Ailurus fulgens), with bacterial infection being one of the most important health threats to the captive population. To date, studies about the Escherichia coli infection in the red panda are scarce. This study was conducted to determine the cause of death of a captive red panda through clinical symptoms, complete blood count, biochemical analysis, pathological diagnosis and bacterial whole genome sequencing.Case presentationOne 1.5 year old captive female red panda (Ailurus fulgens) was lethargic and anoretic. She was moved to the quarantine area for daily treatment of oral cefpodoxime proxetil 50mg. During this period, she did not eat or defecate, and died at 15:00 on November 21. Clinical examination revealed the values of neutrophils; alanine aminotransferase (ALT), aspartate aminotransferase (AST) and blood urea nitrogen (BUN) were significantly higher. Histological analysis demonstrated major pathological damage in the kidneys, liver and lungs, characterized by hyperemia, parenchymal cell degeneration and necrosis and inflammatory cell infiltration which was predominantly neutrophilic. A bacterial strain confirmed as Escherichia coli was isolated from the red panda post mortem. Whole-genome sequencing of the E. coli showed the complete sequences of the chromosome was 4.99 Mbp. PapA, PapG, OmpA, OmpU and other virulence factors were specific to Uropathogenic Escherichia coli (UPEC). Among the virulence factors, P pili, type I pili and related factors of the iron uptake system were associated with nephrotoxicity. ConclusionThe red panda died of bacterial infection caused by an Uropathogenic strain of Escherichia coli. The pathogenic mechanisms of the strain are closely related to the expression of specific virulence genes.

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“…The increasing usage of the clinical antibacterial drug forces the resistance to occur in both pathogenic and zoonotic bacteria in animals [19]. Previous research showed that the appearance of drug resistant strains can make treatment of bacterial infections more difficult, which may lead to an overall increase in transmission, morbidity and mortality [20,21]. These results suggest that effective treatment should be based on the results of antimicrobial susceptibility tests and clinical efficacy in the control of bacteriosis in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Isolation and Identification of Kidney-derived Pathogenic Escherichia coli from Red Panda (Ailurus fulgens)

Liu¹,

Li²,

Yue³

et al. 2020

Preprint

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Background Disease prevention and control is a significant part during the ex-situ conservation of the red panda (Ailurus fulgens) with bacterial infection being one of the important threats to the health of the captive population. So far, there was no systematic and detailed publications about the red panda-related E. coli disease. This study was conducted for the purpose of determining the cause of death, etiology and pathogenesis on a red panda through clinical symptoms, complete blood count, biochemical analysis, pathological diagnosis, antimicrobial susceptibility test, mouse pathogenicity test, and bacterial whole genome sequencing.Results A bacterial strain confirmed as Uropathogenic Escherichia coli (UPEC) was isolated from one captive dead red panda, which is resistant to most of the β-lactam drugs and a small number of aminoglycoside medications. The mouse pathogenicity test results showed the strains isolated postmortem from mice were the same as from the dead red panda, and the pathological findings were similar to the red panda while they were not completely the same. These pathological differences between red panda and mice may be related to the routes of infection and perhaps species differences and tolerance. The whole genome sequencing results showed that the isolated strain contained P pili, type I pili and iron uptake system related factors, which were closely related to its nephrotoxicity. Conclusion The red panda died of bacterial infection which was identified as Uropathogenic Escherichia coli. The pathogenic mechanisms of the strain are closely related to the expression of specific virulence genes.

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Impact of antimicrobial resistance on the treatment of invasive pneumococcal infections

Cited by 13 publications

References 56 publications

Immunization with Polyamine Transport Protein PotD Protects Mice against Systemic Infection with Streptococcus pneumoniae

Immunization with Polyamine Transport Protein PotD Protects Mice against Systemic Infection with Streptococcus pneumoniae

Isolation and Characterization of Uropathogenic Escherichia coli (UPEC) from Red Panda (Ailurus fulgens)

Isolation and Identification of Kidney-derived Pathogenic Escherichia coli from Red Panda (Ailurus fulgens)

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