Impact of antihypertensive treatment on quality of life: comparison between bisoprolol and bendrofluazide

Influence of losartan and atenolol on memory function in very elderly hypertensive patients

“…[49][50][51] Unlike losartan, atenolol treatment did not significantly affect cognitive performance, which is in agreement with some previous observations showing no improvement, but also no deterioration in cognitive function of hypertensive patients treated with beta-blockers. [28][29][30][31][32] The difference between losartan and atenolol in their effects on cognitive function did not depend on their antihypertensive effect, since the BP reduction was similar with the two drugs.…”

“…Centrally acting sympathetic nervous system blocking agents, such as methyldopa and lipophilic beta-blockers like propranolol, have been reported to interfere negatively with memory and cognitive function, [26][27] although other studies have shown no significant adverse effect of beta-blockers including propranolol on cognitive performances. [28][29][30][31][32] Contrasting results have also been reported with diuretics 16,28,30 and calcium antagonists. 17,29,[32][33][34] Only antihypertensive drugs that interfere with the renin-angiotensin system seem to be effective in preventing cognitive decline and even improving cognitive function in hypertensive patients.…”

Bisoprolol and nifedipine retard in elderly hypertensive patients: effect on quality of life

“…Confusion/bewilderment POMS scores did not differ in the dilevalol/bendrofluazide trial, 18 nor in the atenolol/cilazapril/nifedipine trial. 3 Nevertheless dilevalol treatment was significantly better than bendrofluazide when assessed by the objective Digit Symbol Substitution and Symbol Copying tests.…”

“…The disagreement between the result of the two trials may be due to the relatively small numbers being followed for 8 weeks in the de Hoon study. Similarly the randomised cross-over trial of Vanmolkot et al 18 employed the Bulpitt and Fletcher questionnaire and the SRT. The authors compared bisoprolol with bendrofluazide, found no differences, but only studied patients for 8 weeks.…”

“…These data are difficult to interpret but the possibility remains that methyldopa and nifedipine have subtle adverse effects on cognitive function with methyldopa having the greatest impact. This may also be true for propranolol, 15 bendrofluazide [18][19] and nifedipine GITS. 16 A recent observational study revealed increased white matter changes in patients treated with calcium channel blockers.…”