Impact of anti-tuberculosis legislation in Libya on the prevalence of primary and acquired resistance to the three main drugs at a major tuberculosis centre

Khalil, Anita; Sathianathan, S.

doi:10.1016/0041-3879(77)90021-6

Cited by 9 publications

(5 citation statements)

References 2 publications

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“…However, few studies on the rate of MDR-TB in Libya have been reported in the biomedical literature. Khalil and Sathianathan examined the records of 771 Libyans with culture-positive cases of newly diagnosed pulmonary tuberculosis and 789 cases of both Libyans and non-Libyans with positive cultures during treatment on the Regional Tuberculosis and Chest Diseases Centre in Benghazi over a period of approximately 5 years (June 1971-August 1976) (53). They reported that the primary (new cases) and acquired resistance (retreatment cases) to streptomycin, isoniazid, and para-aminosalicylic acid in 1971 were 16.6 and 33.3%, and in 1976 were 8.6 and 14.7%, respectively.…”

Section: Tuberculosis (Tb) and Other Respiratory Tract Infectionsmentioning

confidence: 99%

Antimicrobial resistance in Libya: 1970–2011

Ghenghesh

Rahouma

Tawil

et al. 2013

Libyan Journal of Medicine

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Resistance to antimicrobial agents is a major health problem that affects the whole world. Providing information on the past state of antimicrobial resistance in Libya may assist the health authorities in addressing the problem more effectively in the future. Information was obtained mainly from Highwire Press (including PubMed) search for the period 1970–2011 using the terms ‘antibiotic resistance in Libya’, ‘antimicrobial resistance in Libya’, ‘tuberculosis in Libya’, and ‘primary and acquired resistance in Libya’ in title and abstract. From 1970 to 2011 little data was available on antimicrobial resistance in Libya due to lack of surveillance and few published studies. Available data shows high resistance rates for Salmonella species in the late 1970s and has remained high to the present day. High prevalence rates (54–68%) of methicillin-resistant Staphylococcus aureus (MRSA) were reported in the last decade among S. aureus from patients with burns and surgical wound infections. No reports were found of vancomycin-resistant S. aureus (VRSA) or vancomycin-intermediate-resistant S. aureus (VISA) using standard methods from Libya up to the end of 2011. Reported rates of primary (i.e. new cases) and acquired (i.e. retreatment cases) multidrug-resistant tuberculosis (MDR-TB) from the eastern region of Libya in 1971 were 16.6 and 33.3% and in 1976 were 8.6 and 14.7%, in western regions in 1984–1986 were 11 and 21.5% and in the whole country in 2011 were estimated at 3.4 and 29%, respectively. The problem of antibiotic resistance is very serious in Libya. The health authorities in particular and society in general should address this problem urgently. Establishing monitoring systems based on the routine testing of antimicrobial sensitivity and education of healthcare workers, pharmacists, and the community on the health risks associated with the problem and benefits of prudent use of antimicrobials are some steps that can be taken to tackle the problem in the future.

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Section: Tuberculosis (Tb) and Other Respiratory Tract Infectionsmentioning

confidence: 99%

Antimicrobial resistance in Libya: 1970–2011

Ghenghesh

Rahouma

Tawil

et al. 2013

Libyan Journal of Medicine

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“…Additionally, numerous studies have been reported high primary drug resistance among young and adult population of different areas. [23][24][25] It was observed that primary and acquired drug resistance are main cause of treatment failure. There is significantly high drug A. Salam, J. Kumar, M. H. Chachar et al P J M H S Vol.…”

Section: Discussionmentioning

confidence: 99%

Frequency of Rifampicin Resistance in Primary Pulmonary Tuberculosis at Sheikh Zayed Hospital Rahim Yar Khan

Salam¹,

Kumar²,

Chachar³

et al. 2022

PJMHS

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Background: A World Health organization estimated show that almost 10 million people effect from TB and almost 1.5 million people died from this disease in 2018. Pakistan is ranked 5th in overall TB burden and ranked 4th in drug resistance development of developing countries. About 510,000 case of TB arise every year in Pakistan and 15000 patients develop drug resistance each year. Drug resistance cause huge mortality rate. It should confirm by using drug susceptibility test before treating the patient for drug resistance and for cure. Objective: To find out the frequency of rifampicin resistance in primary pulmonary tuberculosis patient by using drug susceptibility test.

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“…These would clearly include intensive and ongoing undergraduate and postgraduate education. They might also include confining the prescription of anti-tuberculosis drugs to specialists, as in Norway and Libya (Khalil & Sathianathan 1978), or even litigation against misbehaving doctors. As virtually all patients with pulmonary tuberculosis should be cured if effective treatment is prescribed and adhered to, prescribing ineffective treatment amounts to malpractice.…”

Section: Ensuring Well Organized National Tuberculosis Control Programentioning

confidence: 99%

Tuberculosis

Crofton¹

1997

Journal of Pharmacy and Pharmacology

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Impact of anti-tuberculosis legislation in Libya on the prevalence of primary and acquired resistance to the three main drugs at a major tuberculosis centre

Cited by 9 publications

References 2 publications

Antimicrobial resistance in Libya: 1970–2011

Antimicrobial resistance in Libya: 1970–2011

Frequency of Rifampicin Resistance in Primary Pulmonary Tuberculosis at Sheikh Zayed Hospital Rahim Yar Khan

Tuberculosis

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