Impact of antenatal diagnosis on incidence and prognosis in abdominal wall defects

Fisher, Ross; Attah, Augustine; Partington, Ann; Dykes, Evelyn H.

doi:10.1016/s0022-3468(96)90491-1

Cited by 57 publications

(59 citation statements)

References 16 publications

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“…This level of antenatal detection is similar to the highest published detection rates (Fisher et al 1996);(Kilby et al 1998). This high level of antenatal detection reduced the effect of any problems of recruitment related to the late diagnosis of a gastroschisis case to a minimum thus reducing any associated selection bias.…”

Section: Case Definition Identification Selection and Recruitmentsupporting

confidence: 86%

“…For example, data from the Northern Region Fetal Abnormality Survey, excluding first trimester losses, indicated that over the period 1988 to 1992 86% of gastroschisis cases were live born (Dillon and Renwick, 1995), (Fisher et al 1996). In contrast, data from the North Thames West…”

Section: Post-natal Management and Outcomementioning

confidence: 99%

“…Reported levels of gastroschisis cases with multiple anomalies vary from 6% to 25% (Morrow et al 1993); (Fisher et al 1996); (Yang et al 1992); (Calzolari et al 1995); (Torfs et al 1990); (Byron-Scott et al 1998); (Calzolari et al 1993); (Roberts and Burge, 1990). These anomalies range from secondary associations such as intestinal atresia and cryptorchidism to unrelated anomalies including skeletal anomalies, encephalocele and in rare cases aneuploidy or amniotic band sequence.…”

Section: Introduction -Abdominal Wall Defectsmentioning

confidence: 99%

See 2 more Smart Citations

Recreational Drug Use: A Major Risk Factor for Gastroschisis?

Draper

Rankin

Tonks

et al. 2008

Obstetrical &Amp; Gynecological Survey

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Section: Case Definition Identification Selection and Recruitmentsupporting

confidence: 86%

Section: Post-natal Management and Outcomementioning

confidence: 99%

Section: Introduction -Abdominal Wall Defectsmentioning

confidence: 99%

See 1 more Smart Citation

Recreational Drug Use: A Major Risk Factor for Gastroschisis?

Draper

Rankin

Tonks

et al. 2008

Obstetrical &Amp; Gynecological Survey

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“…It is the most common major congenital abnormality of the abdominal wall with an incidence of between 1/4,000 and 1/7,500 live births [2,3]. With the introduction of routine antenatal ultrasound (AUS) scanning in many countries at around 18 weeks' gestation, prenatal diagnosis of exomphalos and its associated anomalies has become common [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Influence of Antenatal Ultrasound on the Management of Fetal Exomphalos

Holland¹,

Ford²,

Linke

et al. 1999

Fetal Diagn Ther

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Objective: To determine the influence of antenatal ultrasound on the management of exomphalos. Methods: Retrospective case note review of 23 fetuses and infants referred to our institution with either a pre- or postnatal diagnosis of exomphalos over a 7-year period. Results: There were 21 cases of exomphalos of which 18 were correctly diagnosed on antenatal ultrasound by 18 weeks’ gestation. There were 2 false-positives and 3 false-negatives, including 1 case of amniotic band syndrome with an abdominal wall defect and 1 morphologically normal fetus. Associated anomalies were correctly identified in 12 but incorrectly reported in 8. Maternal serum α-fetoprotein levels were abnormal in 61% of cases of abdominal wall defects in this series. Amniocentesis was performed in 12 and cordocentesis in 1. There were 13 terminations, including 2 trisomy 18s and 1 trisomy 13. Two fetal deaths followed amniocentesis. Of the 10 live births, 9 had their exomphalos repaired with a 1-year survival rate of 89%. Prenatal diagnosis did not appear to influence outcome. Conclusions: Antenatal ultrasound diagnosed 86% of cases of exomphalos and correctly reported 67% of associated anomalies. Amniocentesis may have led to the death of 1 morphologically normal fetus.

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“…Since MS-AFP screening has become widespread, the prenatal diagnosis of gastroschisis has increased markedly, such that up to 95% of cases are diagnosed before birth. 7 The diagnosis is made on prenatal sonography by observing a ventral wall defect with loops of bowel protruding outside the abdomen, floating freely in the amniotic fluid (Fig. 1).…”

mentioning

confidence: 99%

Postnatal Outcome of Fetuses With the Prenatal Diagnosis of Gastroschisis

Durfee

Downard

Benson

et al. 2002

Journal of Ultrasound in Medicine

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Objective. To assess the postnatal outcome and complications that arise in infants with the prenatal diagnosis of gastroschisis. Methods. Prenatal sonograms with the diagnosis of gastroschisis were identified. Maternal age, indication for sonography, gestational age at diagnosis, other sonographic abnormalities, and postnatal outcome were recorded. Results. Twenty-six fetuses at 16 to 36 weeks' gestational age had gastroschisis diagnosed on sonography. In 5 cases, other fetal anomalies were identified, including hydronephrosis and asymmetric hydrocephalus. In 9 of 21 cases followed by serial prenatal sonography, bowel dilatation developed, prompting delivery in 2. Two of the 26 study fetuses were electively terminated. The remaining 24 were born live and had immediate repair of the gastroschisis after birth. Nineteen infants (79%) had postnatal complications, some with multisystem complications, including 3 deaths, 10 with gastrointestinal complications, 6 with infectious complications, and 6 with anomalies involving other systems (genitourinary, cardiac, central nervous system, and respiratory). Only 5 infants (21%) had completely uncomplicated postsurgical courses. Hospital stays for survivors ranged from 10 to 98 days (mean, 38 days; median, 33 days). Conclusions. Although reported survival rates are good for gastroschisis, the postoperative hospital stay is often lengthy, and complications are very common, especially those related to the gastrointestinal tract. Other anomalies are uncommon but not rare.

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Impact of antenatal diagnosis on incidence and prognosis in abdominal wall defects

Cited by 57 publications

References 16 publications

Recreational Drug Use: A Major Risk Factor for Gastroschisis?

Recreational Drug Use: A Major Risk Factor for Gastroschisis?

Influence of Antenatal Ultrasound on the Management of Fetal Exomphalos

Postnatal Outcome of Fetuses With the Prenatal Diagnosis of Gastroschisis

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