Impact of Ankylosing Spondylitis on Erectile Function

Erdem, İbrahim; Ortaç, Mazhar; Salabaş, Emre

doi:10.14744/semb.2018.49358

Cited by 2 publications

(5 citation statements)

References 20 publications

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“…Several studies demonstrated that higher age, anxiety, and depression in AS patients are risk factors for ED. 8 , 28 However, the opposite result of no association between age and ED in AS patients appears in other studies, 27 , 34 explaining that the association may be blurred by low erectile function in younger AS patients due to disease activity.…”

Section: Discussionmentioning

confidence: 93%

“… 19 Moreover, another study demonstrated that the mean IIEF-EF domain score was significantly lower in the AS group than in the control group. 28 …”

Section: Discussionmentioning

confidence: 99%

“… 16 , 25 A recent study also demonstrated that there was no significant association between disease duration and ED in patients with AS. 28 In addition, ED in men with AS may also be related to higher age and mental disorders (anxiety, depression). Several studies demonstrated that higher age, anxiety, and depression in AS patients are risk factors for ED.…”

Section: Discussionmentioning

confidence: 99%

“…Additionally, restricted physical activity during sexual intercourse could decrease sexual behavior and satisfaction, which also affects psychological status by bringing on depression and anxiety. Erdem et al 28 elucidated that the AS patients with ED showed higher Beck Anxiety Inventory and Beck Depression Inventory scores when compared with AS patients without ED. Ozkorumak et al 17 and Sariyildiz et al 25 reported a significant correlation between IIEF and Hospital Anxiety and Depression Scale scores 36 in AS patients, respectively.…”

Section: Discussionmentioning

confidence: 99%

“… 14 Mental disorders are a risk factor for ED not only in patients with rheumatoid diseases, but also in all cases. 28 These psychological burdens could seriously affect erectile function of AS patients by several mechanisms including negative thinking, decreased sexual desire, and emotional problems. Owing to the limited data, our meta-analysis failed to compare the psychological effect on ED in AS patients, and more clinical study is needed to clarify.…”

Section: Discussionmentioning

confidence: 99%

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Erectile dysfunction in ankylosing spondylitis: a systematic review and meta-analysis

Zhang,

Wu,

Zhang

et al. 2023

Sexual Medicine

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Background The prevalence of erectile dysfunction (ED) in ankylosing spondylitis (AS) patients was reported rarely and with small sample. Aim The study sought to explore the prevalence of ED in men with AS and to determine whether AS is a risk factor for ED. Methods A systematic search was conducted in the China National Knowledge Infrastructure, Wanfang, VIP Database, CBM, PubMed, Web of Science, and Cochrane Library. The search was restricted to the articles published up to October 2022. Assessment tools adapted for prevalence studies were used to evaluate the quality of cross-sectional studies, and the quality of case-control studies was assessed by Newcastle–Ottawa scale. The relative risk (RR) and the standard mean difference (SMD) were used to evaluate the association between AS and ED. The subgroup analyses were conducted to identify the resources of heterogeneity. The sensitivity analysis was performed to assess the stability of the pooled estimates. Data were analyzed and graphed using STATA 16.0. Outcomes The pooled prevalence of ED in AS patients was calculated and the RR and the SMD were used to evaluate the association between AS and ED. Results A total of 393 AS patients, enrolled in the 8 included studies, were assessed for the prevalence of ED. The pooled ED prevalence estimate was 44% (95% confidence interval [CI], 25% to 63%, P < .001) with the statistical heterogeneity (I2 = 95.1%, P < .001). After pooling the data for RR, the results showed that men with AS were at a significantly higher risk for ED when compared with the general population without AS (RR, 2.04; 95% CI, 1.28 to 3.25, P = .003; heterogeneity: I2 = 72.6%, P = .003). The pooled results of 5 studies, which provided the International Index of Erectile Function (IIEF) score, demonstrated that patients with AS had significantly lower values in the IIEF erectile function domain as compared with the healthy control subjects (SMD, −0.60; 95% CI, −0.80 to −0.41; P < .001; heterogeneity: I2 = 34.4%, P = .192). Additionally, the other domain of the IIEF also showed lower values when compared with the general population without AS (P < .05). Clinical Implications The present meta-analysis provides evidence of the management of ED in men with AS. Strengths and Limitations This is the first meta-analysis to provide the prevalence of ED in AS patients and to demonstrate that AS is a risk factor for ED. However, the results after pooling the included studies showed significant heterogeneity. Conclusion Our meta-analysis demonstrated the high prevalence of ED in men with AS and that AS is a potential risk factor for ED.

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Section: Discussionmentioning

confidence: 93%

“… 19 Moreover, another study demonstrated that the mean IIEF-EF domain score was significantly lower in the AS group than in the control group. 28 …”

Section: Discussionmentioning

confidence: 99%