Impact of anemia on nonfatal coronary events after percutaneous coronary interventions

Çatakoğlu, Alp Burak; Aytekin, Saide; Şener, Murat; Kurtoğlu, Hi̇lal; Celebi, Huseyin; Demiroglu, I.C. Cemsid; Aytekin, Vedat

doi:10.1007/s00380-007-0995-8

Cited by 9 publications

(6 citation statements)

References 21 publications

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“…In our series, renal disease was more frequent in patients with a prior anemia, and renal dysfunction is known to be an adverse prognostic marker in patients with ischemic heart disease [26], in particular in those who are anemic [27]. In the acute phase, the presence of a prior anemia was also associated with a higher incidence of PCI failure, thus confirming previous investigations, reporting a higher occurrence of complications in anemic patients after PCI [27,28]. In fact, in patients submitted to elective PCI, anemia has a role in nonfatal thrombotic coronary events and restenosis [28] and it is associated with higher short term adverse procedural events.…”

Section: Discussionsupporting

confidence: 90%

“…In the acute phase, the presence of a prior anemia was also associated with a higher incidence of PCI failure, thus confirming previous investigations, reporting a higher occurrence of complications in anemic patients after PCI [27,28]. In fact, in patients submitted to elective PCI, anemia has a role in nonfatal thrombotic coronary events and restenosis [28] and it is associated with higher short term adverse procedural events. In our series, though the use of abciximab was lower in patients with a prior anemia, the incidence of major bleedings was higher in these patients, in agreement with previous reports [4,5,19,29].…”

Section: Discussionsupporting

confidence: 84%

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Prior and new onset anemia in ST-elevation myocardial infarction: a different prognostic role?

et al. 2010

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The present investigation, performed in 1,122 consecutive STEMI patients treated with primary coronary intervention, was aimed at evaluating: (1) the prevalence of prior anemia and its prognostic significance in the short term; and (2) the prevalence of new anemia and its impact in the short term. The prevalence of prior anemia was 27.4%. Patients with a prior anemia were older and exhibited a higher incidence of chronic diseases and comorbidities. They showed a higher intra-hospital mortality rate (p \ 0.001), a higher incidence of PCI failure (p \ 0.001) and major bleedings (p \ 0.001). Prior anemia was an independent predictor for intra-hospital mortality (OR 2.12; 95% CI 1.21-3.70, p = 0.009). Patients with a new anemia account for 46.8% of our series, and showed a higher early mortality rate and incidence of major bleedings in respect to those who maintained normal Hb values (p \ 0.05 and \0.05, respectively). our data strengthens the prognostic role of Hb values in STEMI patients submitted to primary PCI, since the presence of prior anemia identified a subset of patients, characterized by advanced age, higher comorbidities and serious coronary artery disease, at higher risk for intra ICCU mortality and complications. Moreover, the development of anemia during an ICCU stay is common, and is associated with a higher mortality rate and incidence of complications in respect to patients who maintain normal Hb values.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 84%

Prior and new onset anemia in ST-elevation myocardial infarction: a different prognostic role?

et al. 2010

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“…Several cohort studies have consistently demonstrated that a low hemoglobin level at admission is a powerful predictor for mortality and morbidity in patients with coronary artery disease [1,2] especially when admitted for an ACS [3][4][5][6]. Hemoglobin levels may also decrease during the hospital stay.…”

Section: Introductionmentioning

confidence: 98%

Prognostic value of hemoglobin decline over the GRACE score in patients hospitalized for an acute coronary syndrome

et al. 2011

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In this work, we analyzed the prognostic significance of changes in hemoglobin during intensive care unit (ICU) stay in patients with acute coronary syndromes (ACS). We prospectively enrolled 591 patients (62 ± 14 years old, 73% male, 48% ST elevated myocardial infarction) free of blood cell transfusion or bleeding events. Changes in hemoglobin between admission and ICU discharge were obtained. The primary endpoint was death or hospitalization for MI within 6 months. Hemoglobin decreased from 13.65 ± 1.77 to 13.17 ± 1.74 g/dl, p < 0.0001 in the whole population. The end point was reached in 43 patients at a mean follow-up of 180 (range 2-180 days). A decrease in hemoglobin ≥0.9 g/dl (32% of the population) was associated with adverse clinical outcomes (HR 2.37, 95% CI (1.30-4.35), p = 0.005, respectively). In multivariate analysis, age >77 year-old (p = 0.0016), Killip class ≥2 (p = 0.009), anemia (p = 0.0064), decreased estimated glomerular filtration rate (p = 0.003), and hemoglobin decline ≥0.9 g/dl (p < 0.0001) were independently associated with outcome. Hemoglobin decline and anemia both provided additional prognostic information on top of the GRACE score, as demonstrated by a systematic improvement in model global fit, discrimination, and calibration. Hemoglobin decline is frequent during ICU stay in non-bleeding ACS patients. A decline in hemoglobin ≥0.9 g/dl identifies high-risk patients. Identification of these patients refines the prognostic value of the GRACE score.

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“…Catakoglu et al [13]demonstrated that anemia is an important risk factor for predicting nonfatal coronary events after PCI, which included ST-segment elevation MI, non ST-segment elevation MI, target-vessel revascularization (TVR ) and target-lesion revascularization (TLR). While Geng et al [12]found no statistic signi cant relation between low hemoglobin and ISR.…”

Section: Discussionmentioning

confidence: 99%

Impact of anemia on in-stent restenosis after percutaneous coronary intervention

Wang

Tang

Zhai

et al. 2021

Preprint

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Background Anemia is a well-recognized risk factor for adverse events after percutaneous coronary intervention (PCI), but data regarding the association between anemia and in-stent restenosis (ISR) remain limited.Methods A total of 538 patients who underwent PCI between January 2018 and September 2019 and performed follow-up angiography 9–12 months after the initial PCI was enrolled in the study. Baseline clinical and procedural characteristics were compared between ISR and non-ISR group. Multivariate logistic regression analysis was employed to determine the independent predictors of ISR.Results The incidence of anemia in patients with ISR was 53.5% and 19.0% in the non-ISR group, which was significantly different (P ༜0.001). The rate of diabetes, chronic kidney disease (CKD), bifurcation lesion and calcification was significantly higher in ISR group. In addition, low-density lipoprotein cholesterol (LDL-c), multiple stenting and stent diameter were also significantly related with ISR. After multivariate logistic analysis, anemia (odds ratio [OR], 2.786; 95% confidence interval [CI], 1.091 to 7.115; P = 0.032) together with LDL-c (OR, 1.682; 95% CI, 1.145 to 2.469; P = 0.008), diabetes (OR, 3.582; 95% CI, 1.406 to 9.125; P = 0.007), CKD (OR, 2.841; 95% CI, 1.006 to 8.027; P = 0.049), multiple stenting (OR, 2.823; 95% CI, 1.184 to 6.731; P = 0.019), and stent diameter (OR, 2.778; 95% CI, 1.069 to 7.194; P = 0.036) were closely associated with ISR.Conclusion Anemia is closely associated with ISR after PCI, patients with lower hemoglobin have a higher risk of ISR.

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Impact of anemia on nonfatal coronary events after percutaneous coronary interventions

Cited by 9 publications

References 21 publications

Prior and new onset anemia in ST-elevation myocardial infarction: a different prognostic role?

Prior and new onset anemia in ST-elevation myocardial infarction: a different prognostic role?

Prognostic value of hemoglobin decline over the GRACE score in patients hospitalized for an acute coronary syndrome

Impact of anemia on in-stent restenosis after percutaneous coronary intervention

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