Impact of and Interaction between the Availability of Prior Examinations and DBT on the Interpretation of Negative and Benign Mammograms

Hakim, Christiane M.; Anello, Marie I.; Cohen, Cathy S.; Ganott, Marie A.; Lu, Amy; Perrin, Ronald L.; Shah, Rachit D.; Spangler, Marion Lee; Bandos, Andriy I.; Gur, David

doi:10.1016/j.acra.2013.10.015

Cited by 7 publications

(4 citation statements)

References 10 publications

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“…The possibility was as high as 81%-97% among the patients with a burr on edge of tumor, a positive burr sign hinting possible breast cancer to a great extent (Smith, 2005;Gong et al, 2006) Poplack et al (Poplaek et al, 2007) deemed that DBT images, especially the images of tumors, were superior to traditional FFDM images. From the results, we might make judgment of a benign tumor for a mass with a smooth edge, clear borders and a fine uniform bright ring around it, which is consistent with the previous study (Hakim et al, 2014). This might provide a more accurate basis of images for the minimally invasive surgery expected by the women who love beauty.…”

Section: Discussionsupporting

confidence: 85%

Significance and Application of Digital Breast Tomosynthesis for the BI-RADS Classification of Breast Cancer

Cai

Yan²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Full-field digital mammography (FFDM) with dense breasts has a high rate of missed diagnosis, and digital breast tomosynthesis (DBT) could reduce organization overlapping and provide more reliable images for BI-RADS classification. This study aims to explore application of COMBO (FFDM+DBT) for effect and significance of BI-RADS classification of breast cancer. Materials and Methods: In this study, we selected 832 patients who had been treated from May 2013 to November 2013. Classify FFDM and COMBO examination according to BI-RADS separately and compare the differences for glands in the image of the same patient in judgment, mass characteristics display and indirect signs. Employ Paired Wilcoxon rank sum test was used in 79 breast cancer patients to find differences between two examine methods. Results: The results indicated that COMBO pattern is able to observe more details in distribution of glands when estimating content. Paired Wilcoxon rank sum test showed that overall classification level of COMBO is higher significantly compared to FFDM to BI-RADS diagnosis and classification of breast (P<0.05). The area under FFDM ROC curve is 0.805, while that is 0.941 in COMBO pattern. COMBO shows relation of mass with the surrounding tissues, the calcification in the mass, and multiple foci clearly in breast cancer tissues. The optimal sensitivity of cut-off value in COMBO pattern is 82.9%, which is higher than that in FFDM (60%). They share the same specificity which is both 93.2%. Conclusions: Digital Breast Tomosynthesis (DBT) could be used for the BI-RADS classification in breast cancer in clinical.

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Section: Discussionsupporting

confidence: 85%

Significance and Application of Digital Breast Tomosynthesis for the BI-RADS Classification of Breast Cancer

Cai

Yan²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Current studies by Hakim et al. also reported that recall rates were able to be reduced with the addition of prior images by 34% and 32% without and with DBT images (16,17) although their study did not describe the effect of prior mammograms on diagnostic performance in terms of sensitivity and specificity.…”

Section: Discussionmentioning

confidence: 94%

“…The use of prior mammograms in the reading of current mammograms had previously been reported to increase specificity especially in the screening setting (13,15), while also increasing the detection of true-positive findings in the diagnostic setting (1). Current studies by Hakim et al also reported that recall rates were able to be reduced with the addition of prior images by 34% and 32% without and with DBT images (16,17) although their study did not describe the effect of prior mammograms on diagnostic performance in terms of sensitivity and specificity.…”

Section: Discussionmentioning

confidence: 99%

Impact of prior mammograms on combined reading of digital mammography and digital breast tomosynthesis

et al. 2016

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Background Although digital breast tomosynthesis (DBT) is an emerging technique yielding higher sensitivity and specificity compared to digital mammography (DM) alone, relative contribution of prior mammograms on the interpretation of DBT combined with DM has not been investigated. Purpose To retrospectively compare the diagnostic performances of DM, DM + DBT, and DM + DBT with prior mammograms. Material and Methods Three breast radiologists independently reviewed images of 116 patients with 24 cancers in the sequential order of DM, DM + DBT, and DM + DBT with prior mammograms using Breast Imaging Reporting and Data System (BI-RADS) assessment categories. Results The average areas under the receiver operating characteristic curve (AUC) of DM, DM + DBT, and DM + DBT with prior mammograms were 0.712, 0.777, and 0.816, respectively. Adding prior mammograms did not significantly affect the AUC of DM + DBT ( P = 0.108), whereas adding DBT significantly increased the AUC of DM ( P = 0.009). Sensitivity for DM, DM + DBT, and DM + DBT with prior mammograms was 58.3%, 69.4%, and 69.4%, and specificities were 84.1%, 85.9%, and 93.8%, respectively. Addition of DBT significantly increased the sensitivity ( P = 0.0090) of DM. Prior mammograms significantly improved the specificity of DM + DBT ( P = 0.0004), whereas adding prior mammogram did not affect sensitivity of DM + DBT ( P = 1.000). Conclusion DBT significantly increases the overall sensitivity and diagnostic performance of DM. Prior mammograms significantly increase the specificity of DM + DBT but have no significant effect on sensitivity and overall diagnostic performance.

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“…Study Population FFDM and DBT images obtained in 153 women who ranged in age from 37 to 83 years (mean age, 53.7 years 6 9.3 [standard deviation]) were sequentially selected for this study from a pool of 519 studies (predominantly from prior research studies), 36 of which were used in a pilot study (16) and were excluded from this study. The selection of cases was based on the availability of a prior FFDM study obtained between 1 and 3 years prior to the current FFDM and DBT studies of interest and the requirement to fulfill a desired distribution of verified outcomes, breast densities, and abnormality types.…”

Section: Breast Imaging: Full-field Digital Mammography and Digital Bmentioning

confidence: 99%

Effect of the Availability of Prior Full-Field Digital Mammography and Digital Breast Tomosynthesis Images on the Interpretation of Mammograms

Hakim¹,

Catullo²,

Chough³

et al. 2015

Radiology

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Purpose:To assess the effect of and interaction between the availability of prior images and digital breast tomosynthesis (DBT) images in decisions to recall women during mammogram interpretation. Materials and Methods:Verbal informed consent was obtained for this HIPAA-compliant institutional review board-approved protocol. Results:Average recall rates in noncancer cases were significantly reduced with the addition of prior FFDM images by 34% (145 of 421) and 32% (106 of 333) without and with DBT images, respectively (P , .001). However, this recall reduction was achieved at the cost of a corresponding 7% (23 of 345) and 4% (14 of 353) reduction in sensitivity (P = .006). In contrast, availability of DBT images resulted in a smaller reduction in recall rates (false-positive interpretations) of 19% (76 of 409) and 26% (71 of 276) without and with prior FFDM images, respectively (P = .001). Availability of DBT images resulted in 4% (15 of 338) and 8% (25 of 322) increases in sensitivity, respectively (P = .007). The effects of the availability of prior FFDM images or DBT images did not significantly change regardless of the sequence in presentation (P = .81 and P = .47 for specificity and sensitivity, respectively). Conclusion:The availability of prior FFDM or DBT images is a largely independent contributing factor in reducing recall recommendations during mammographic interpretation.q RSNA, 2015

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Impact of and Interaction between the Availability of Prior Examinations and DBT on the Interpretation of Negative and Benign Mammograms

Cited by 7 publications

References 10 publications

Significance and Application of Digital Breast Tomosynthesis for the BI-RADS Classification of Breast Cancer

Significance and Application of Digital Breast Tomosynthesis for the BI-RADS Classification of Breast Cancer

Impact of prior mammograms on combined reading of digital mammography and digital breast tomosynthesis

Effect of the Availability of Prior Full-Field Digital Mammography and Digital Breast Tomosynthesis Images on the Interpretation of Mammograms

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