Impact of an antimicrobial stewardship program in a COVID-19 reference hospital according to the AWaRe classification

Telles, João Paulo; Yamada, Carolina Hikari; Dario, Thayrine Mayara; Miranda, Alexia Nascimento; Pacheco, Alceu; Tuon, Felipe Francisco

doi:10.1016/j.ajic.2022.07.010

Cited by 2 publications

(1 citation statement)

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“…Carbapenems and FQs are classified as reserve and watch groups, according to the World Health Organization (WHO) antimicrobial classification. The WHO target is that by 2023, at least 60% of all antimicrobial consumption should come from the access group ( , accessed on 25 January 2023) but the COVID-19 pandemic made it difficult to achieve this target [ 29 ].…”

Section: Discussionmentioning

confidence: 99%

Rapid Decrease in Fluoroquinolones Consumption following Implementation of a Simple Antimicrobial Stewardship Bundled Intervention in a University Hospital during the COVID-19 Pandemic

et al. 2023

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Fluoroquinolones (FQs) represent an class of antibiotics of medical importance, but their use has been restricted due to their ecologic impact and associated side effects. The reduction of FQs use is an important goal of antimicrobial stewardship programs (ASP). This work describes an ASP focused on overall antibiotics and FQs consumption reduction. From January 2021, an ASP was implemented in a 700-bed teaching hospital. The ASP was based on: (i) antibiotics consumption monitoring system (DDD/100 bed days); (ii) mandatory antibiotic prescription-motivation (using a dedicated informatic format) with the goal of >75% of motivated prescriptions; and (iii) data feedback and training on FQs use indications. We evaluated the impact of the intervention on overall systemic antibiotics and FQs consumption according to the objectives posed by Italian PNCAR (National Action Plan on Antimicrobial Resistance). A decrease of 6.6% in antibiotic use was observed (2019 vs. 2021). Notably, the FQs consumption fell by 48.3% from 7.1 DDD/100 bd in 2019 to 3.7 DDD/100 bd in 2021 (p < 0.001). After six months of mandatory antibiotic prescription-indication, all units achieved the target set. The study suggests that a simple, bundled ASP intervention can be rapidly effective obtaining the objectives of PNCAR on the reduction of overall antibiotics and FQs consumption.

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Section: Discussionmentioning

confidence: 99%