Impact of Alcohol on Bone Health in People Living With <scp>HIV</scp>: Integrating Clinical Data From Serum Bone Markers With Morphometric Analysis in a Non‐Human Primate Model

Denys, Alexandra; Perrien, Daniel S.; Suva, Larry J.; Simon, Liz; McDaniel, Lee S.; Ferguson, Tekeda; Pedersen, Kim Brint; Welsh, David A.; Molina, Patricia; Ronis, Martin J. J.

doi:10.1002/jbm4.10703

Cited by 3 publications

(3 citation statements)

References 73 publications

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“…Furthermore, a prospective cohort study found that higher alcohol intake is significantly associated with lower levels of procollagen type 1 N-terminal propeptide (P1NP), another bone formation biomarker, further confirming the negative impact of alcohol on bone formation in PWH with substance use disorder [70]. Corroborating these findings, another study within the New Orleans Alcohol Use in HIV cohort demonstrated that alcohol use inversely correlates with both osteocalcin and P1NP levels, with these effects being more pronounced in individuals over 50 years of age and in postmenopausal women, highlighting the compounded risk in these subpopulations [71]. Additionally, the study noted positive correlations between serum sclerostin levels and alcohol use, suggesting a potential pathway through which alcohol may exert its osteopenic effects.…”

Section: Smoking and Alcohol Usementioning

confidence: 73%

Bone Disease in HIV: Need for Early Diagnosis and Prevention

Schinas,

Ntampanlis

et al. 2024

Life

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The transformation of HIV into a manageable chronic condition has unveiled new clinical challenges associated with aging-related pathologies, including bone disease. This review explores the intricate relationship between HIV, antiretroviral therapy (ART), and bone disease, highlighting the necessity of early diagnosis and preventative strategies to mitigate the increased risk of osteopenia, osteoporosis, and fractures in people living with HIV (PLWHIV). It synthesizes the current literature to elucidate the multifactorial etiology of bone pathology in this population, that includes direct viral effects, chronic immune activation, ART-associated risks, and the impact of traditional risk factors for bone loss. Through a critical examination of modern diagnostic methods, lifestyle modifications, evidence-based preventive actions, and pharmacological treatments, the necessity for comprehensive management is highlighted, along with recommendations for integrated healthcare approaches vital for achieving optimal patient outcomes. By advocating for a proactive, patient-centered, and multidisciplinary strategy, this review proposes a plan to integrate bone health into standard HIV care through active risk identification, vigilant screening, effective preventive measures, tailored treatments, and informed decision-making, in an effort to ultimately enhance the quality of life for PLWHIV.

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Section: Smoking and Alcohol Usementioning

confidence: 73%

Bone Disease in HIV: Need for Early Diagnosis and Prevention

Schinas,

Ntampanlis

et al. 2024

Life

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“…Besides sheep, non‐human primates and species like rhesus macaques, Macaca mulatta , or Papio ursinus have been used for bone research. ( 175‐177 ) For ethical reasons, these experiments are not possible in Europe. Several successful approaches highlight the translational potential of these models, for example, in demonstrating that alcohol is a risk factor for osteoporosis after HIV infection.…”

Section: In Vivo Models For Skeletal Research: State Of the Artmentioning

confidence: 99%

“…Several successful approaches highlight the translational potential of these models, for example, in demonstrating that alcohol is a risk factor for osteoporosis after HIV infection. ( 175 ) Non‐human primates have also been used to test biologicals for osteoporosis treatment or fracture healing. ( 178,179 ) Particularly in translational bone research, non‐human primates are the most accurate model in terms of bone metabolism and structure.…”

Section: In Vivo Models For Skeletal Research: State Of the Artmentioning

confidence: 99%

Why Animal Experiments Are Still Indispensable in Bone Research: A Statement by the European Calcified Tissue Society

Stein,

Elefteriou,

Busse

et al. 2023

J of Bone & Mineral Res

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Major achievements in bone research have always relied on animal models and in vitro systems derived from patient and animal material. However, the use of animals in research has drawn intense ethical debate and the complete abolition of animal experimentation is demanded by fractions of the population. This phenomenon is enhanced by the reproducibility crisis in science and the advance of in vitro and in silico techniques. 3D culture, organ‐on‐a‐chip, and computer models have improved enormously over the last few years. Nevertheless, the overall complexity of bone tissue cross‐talk and the systemic and local regulation of bone physiology can often only be addressed in entire vertebrates. Powerful genetic methods such as conditional mutagenesis, lineage tracing, and modeling of the diseases enhanced the understanding of the entire skeletal system. In this review endorsed by the European Calcified Tissue Society (ECTS), a working group of investigators from Europe and the US provides an overview of the strengths and limitations of experimental animal models, including rodents, fish, and large animals, as well the potential and shortcomings of in vitro and in silico technologies in skeletal research. We propose that the proper combination of the right animal model for a specific hypothesis and state‐of‐the‐art in vitro and/or in silico technology is essential to solving remaining important questions in bone research. This is crucial for executing most efficiently the 3R principles to reduce, refine, and replace animal experimentation, for enhancing our knowledge of skeletal biology, and for the treatment of bone diseases that affect a large part of society. © 2023 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

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