Impact of Alcohol and Coffee Intake on the Risk of Advanced Liver Fibrosis: A Longitudinal Analysis in HIV-HCV Coinfected Patients (ANRS CO-13 HEPAVIH Cohort)

Abstract

Background: Coffee intake has been shown to modulate both the effect of ethanol on serum GGT activities in some alcohol consumers and the risk of alcoholic cirrhosis in some patients with chronic diseases. This study aimed to analyze the impact of coffee intake and alcohol consumption on advanced liver fibrosis (ALF) in HIV-HCV co-infected patients. Methods: ANRS CO13-HEPAVIH is a French, nationwide, multicenter cohort of HIV-HCV-co-infected patients. Sociodemographic, behavioral, and clinical data including alcohol and coffee consumption were prospectively collected using annual self-administered questionnaires during five years of follow-up. Mixed logistic regression models were performed, relating coffee intake and alcohol consumption to ALF. Results: 1019 patients were included. At the last available visit, 5.8% reported high-risk alcohol consumption, 27.4% reported high coffee intake and 14.5% had ALF. Compared with patients with low coffee intake and high-risk alcohol consumption, patients with low coffee intake and low-risk alcohol consumption had a lower risk of ALF (aOR (95% CI) 0.24 (0.12–0.50)). In addition, patients with high coffee intake had a lower risk of ALF than the reference group (0.14 (0.03–0.64) in high-risk alcohol drinkers and 0.11 (0.05–0.25) in low-risk alcohol drinkers). Conclusions: High coffee intake was associated with a low risk of liver fibrosis even in HIV-HCV co-infected patients with high-risk alcohol consumption.

cAMP Signaling in Pathobiology of Alcohol Associated Liver Disease

“…There are conflicting reports on the role of adenosine receptors in HSC activation in response to the alcohol metabolite acetaldehyde. Caffeine, which has been shown to be beneficial in liver fibrosis (reviewed in [ 164 , 165 , 166 ]), has been reported to block A 1 , A 2A and A 2B receptors [ 167 ]. However, coffee has also been demonstrated to inhibit PDE activity and increase cAMP levels in several studies [ 168 , 169 , 170 , 171 ].…”

The Impact of Caffeine and Coffee on Human Health

“…Van Dijk et al [ 21 ] reviewed the effects of caffeine on myocardial blood flow, which support a significant and clinically relevant influence of recent caffeine intake on cardiac perfusion measurements during adenosine and dipyridamole induced hyperemia. Original observational reports on the association between habitual coffee consumption and liver fibrosis [ 22 ], depression [ 23 ], hearing [ 24 ], and cognition indices [ 25 ] have extended the research in these areas to new populations.…”

Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer’s and Parkinson’s Disease: Insight into the Role of Nrf-2 and A2AR Signaling

“…They indicated that coffee intake might preserve the neurocognitive functioning in people living with HIV and HCV [ 157 ]. Other studies on the association between habitual coffee consumption and liver fibrosis [ 158 ], depression [ 159 ], hearing [ 160 ], and cognition indices [ 161 ] highlighted the beneficial effects of coffee. A study on the impact of caffeine intake on PD progression was conducted, which showed that healthy individuals with regular caffeine consumption had a lower risk of PD during follow-up observation.…”