This paper considers various applications of heat exchangers in refrigerators, air conditioning, and nuclear power plants in recent years, current issues and trends, including the required capacity of refrigerator heat exchanger and the corresponding advantages of microchannel heat exchanger, refrigerator application of frost problems, ash problems and improve the performance of the relevant research; Examples of application of microchannel heat exchanger in air conditioning, comparison with traditional heat exchanger, and improvements to problems such as frost, the distribution of fluids, corrosion found in experiments; Study on advantages of compact microchannel heat exchanger in nuclear power plant. The purpose of this paper is to fill the gap in the application of microchannel heat exchanger and provide reference for future research.