Impact of Air Pollution on Age and Gender Related Increase in Cough Reflex Sensitivity of Healthy Children in Slovakia

Demoulin‐Alexikova, Silvia; Plevková, Jana; Mazurova, Lenka; Zatko, Tomás; Alexik, Mikulas; Hanácek, J; Tatar, Marc

doi:10.3389/fphys.2016.00054

Cited by 21 publications

(9 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long-term exposure to ambient air pollution could cause cough in healthy girls [ 13 ]. These results were confirmed by a more recent study showing that living in urban area had the potential to trigger cough and to cause cough hypersensitivity, in particular in school-aged girls, suggesting an implication of several biological and behavioral factors, changing with age and gender, in the relation between air pollution and cough [ 14 ].…”

Section: Main Textsupporting

confidence: 65%

XII AIST 2018 Conference: “The thousand faces of cough: clinical and therapeutic updates”

Zanasi

Morselli-Labate

Mazzolini

et al. 2018

Multidiscip Respir Med

View full text Add to dashboard Cite

This paper summarizes the presentations submitted for publication of the 12th AIST National Congress (Associazione Italiana Studio Tosse/Italian Association for Cough Study) entitled “The thousand facets of cough. A clinical and therapeutic update”, which occurred last February 2nd-3rd, 2018 in Bologna (Italy). It summarizes the contributions from leading experts of the sector, who, as in the previous editions, also this year have analyzed a problem too often underestimated which still has many dark sides as regards both the diagnosis and the therapy of cough. The Scientific Committee has chosen topics that had less space in previous editions and these are topical subjects representing a concrete opportunity for learning and comparison of opinions, as well as indispensable elements for the correct management of the symptoms.Hereby we report the abstracts of the works submitted for publication in this Meeting report.The main topics have covered Cough relationship with nerve vagus, ATP, air pollution, GERD, imaging, COPD, pediatric and therapy. Of particular interest it is the preliminary data on cough hydration ratio that shows a highly significant correlation between dehydration and cough.Electronic supplementary materialThe online version of this article (10.1186/s40248-018-0130-y) contains supplementary material, which is available to authorized users.

show abstract

Section: Main Textsupporting

confidence: 65%

XII AIST 2018 Conference: “The thousand faces of cough: clinical and therapeutic updates”

Zanasi

Morselli-Labate

Mazzolini

et al. 2018

Multidiscip Respir Med

View full text Add to dashboard Cite

show abstract

“…Paediatric cough is best considered as a symptom of an underlying disease. Therefore, the burden of disease is influenced by the quality of the healthcare system as well as healthcare independent factors such as age range [29][30][31], sex and indoor and outdoor air pollution [32].…”

Section: Impact On Patientsmentioning

confidence: 99%

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

et al. 2019

View full text Add to dashboard Cite

These guidelines incorporate the recent advances in chronic cough pathophysiology, diagnosis and treatment. The concept of cough hypersensitivity has allowed an umbrella term that explains the exquisite sensitivity of patients to external stimuli such a cold air, perfumes, smoke and bleach. Thus, adults with chronic cough now have a firm physical explanation for their symptoms based on vagal afferent hypersensitivity. Different treatable traits exist with cough variant asthma (CVA)/eosinophilic bronchitis responding to anti-inflammatory treatment and non-acid reflux being treated with promotility agents rather the anti-acid drugs. An alternative antitussive strategy is to reduce hypersensitivity by neuromodulation. Low-dose morphine is highly effective in a subset of patients with cough resistant to other treatments. Gabapentin and pregabalin are also advocated, but in clinical experience they are limited by adverse events. Perhaps the most promising future developments in pharmacotherapy are drugs which tackle neuronal hypersensitivity by blocking excitability of afferent nerves by inhibiting targets such as the ATP receptor (P2X3). Finally, cough suppression therapy when performed by competent practitioners can be highly effective. Children are not small adults and a pursuit of an underlying cause for cough is advocated. Thus, in toddlers, inhalation of a foreign body is common. Persistent bacterial bronchitis is a common and previously unrecognised cause of wet cough in children. Antibiotics (drug, dose and duration need to be determined) can be curative. A paediatric-specific algorithm should be used.

show abstract

“…Ambient air pollution is a mixture of particulate matter and gases, which may also be associated with cough [ 38 ]. Moreover, other airborne particulates, such as pollen [ 39 ], fungus [ 40 ], or passive smoking [ 41 ], may affect results of this study because these are triggers for cough. Also, travelers’ fatigue could be a strong factor that affects the results of the pulmonary function test and cough reflex sensitivity test [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Short-Term Exposure to High Particulate Levels on Cough Reflex Sensitivity in Healthy Tourists: A Pilot Study

Sato¹,

Gui²,

Ito³

et al. 2016

TORMJ

View full text Add to dashboard Cite

Background:Previous studies have reported a relationship between particulate air pollution and respiratory symptoms or decline in lung function, but information about acute effects of short-term exposure to airborne particulate matter (PM) on cough and pulmonary function is scarce.Objective:To investigate the effect of short-term exposure to high concentrations of PM on the cough reflex threshold, urge-to-cough, pulmonary function, and cough-related quality of life in a group of healthy non-resident volunteers visiting Beijing, China.Methods:Seventeen healthy residents of Sendai, Japan, who planned to attend a meeting in Beijing, were recruited. We checked local air quality and measured cough reflex thresholds, urge-to-cough, pulmonary function, and Leicester Cough Questionnaire-acute (LCQ-acute) scores in the volunteers before, during, and after their trip to Beijing.Results:The PM2.5 and PM10 concentrations in Beijing were significantly higher than those in Japan on the measurement days. Cough reflex thresholds, expressed as nebulized citric acid concentrations required to induce ≥ 2 and ≥ 5 coughs, were significantly lower during the stay in Beijing than before or after the visit. Vital capacity, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC were significantly lower during the stay in Beijing than before the trip. Similarly, the urge-to-cough threshold was significantly lower during the stay in Beijing than after the trip, as was the total LCQ-acute score.Conclusion:We tentatively concluded that short-term exposure to high PM concentrations may have adverse effects on cough reflex and urge-to-cough thresholds, pulmonary function, and cough-related quality of life.

show abstract

Impact of Air Pollution on Age and Gender Related Increase in Cough Reflex Sensitivity of Healthy Children in Slovakia

Cited by 21 publications

References 88 publications

XII AIST 2018 Conference: “The thousand faces of cough: clinical and therapeutic updates”

XII AIST 2018 Conference: “The thousand faces of cough: clinical and therapeutic updates”

ERS guidelines on the diagnosis and treatment of chronic cough in adults and children

Effect of Short-Term Exposure to High Particulate Levels on Cough Reflex Sensitivity in Healthy Tourists: A Pilot Study

Contact Info

Product

Resources

About