Impact of Aging on Nerve Conduction Velocities and Late Responses in Healthy Individuals

Abstract

Background:Nerve conduction studies are performed to diagnose the disorders of the peripheral nervous system. The reference values for nerve conduction velocity (NCV) and late responses for different nerves considerably vary in different group and type of population. Physiological factors such as age, temperature, height, and gender affect the NCV. However, there are very few studies which show the age group at which these changes become significant.Aim and Objectives:The aim of the study was to establish the electrophysiological data of the specific age group at which changes in NCV as well as late responses of median common peroneal nerve and also see the late response in the form of F-waves and H-reflex.Methodology:Study groups were divided into three categories based on the age: Group I (18–30 years) (n = 80), Group II (31–45 years) (n = 43), and Group III (46–60 years) (n = 27). Out of which, 93 patients were male and 57 were female. The NCVs were determined for median, common peroneal nerve (motor component and sensory component) along with late responses in the form of H-reflex and F-waves.Results:The mean and standard deviation of median, ulnar, peroneal, and tibial nerve was studied for latencies, amplitude, and velocities for both sensory and motor components. Patients with older age had longer latencies, smaller amplitudes, and slower conduction velocities compared with the younger age group. The change with age was greater in sensory nerve conduction and late responses in all the peripheral nerves.Conclusions:Aging has a definite correlation with the NCV and late responses of different peripheral nerves. There is a need to have reference values with relation to age.

Human Nerve-on-a-Chip. Engineering 3D functional human peripheral nerve in vitro

“…Furthermore, the presence of non-neuronal cell bodies in co-culture spheroids decreases the probability of recording from the appropriately stimulated cell bodies. Importantly, NCV from hNs was found to be considerably lower as compared to the NCV values obtained in human patients [31][32][33] . This is not particularly surprising, considering an in vitro system, at room temperature, comprised of iPSC-derived neurons that are less mature as compared to mature, myelinated axons of nerves assessed in vivo.…”

Carpal tunnel syndrome in advanced age: A sonographic and electrodiagnostic study

“…Because SNAP and CMAP amplitudes decrease with age and DML lengthens, it is possible that, given that we used the same “normal” cutoff values in both groups, some elderly patients could have been misclassified electrodiagnostically as being more severe than they truly were. Although the magnitude of this effect is likely to have been small, it may have been significant …”

“…Although the magnitude of this effect is likely to have been small, it may have been significant. [29][30][31] We chose to use Pearson's correlation coefficient to examine the relationship between variables in our study. The small sample size and skewed disease distribution toward the severe end in our elderly population may have had an impact on our correlation measures.…”

Central and Peripheral Neuromuscular Adaptations to Ageing

“…Disfunction of spinal motor neurons, as well as reduced axonal myelination and reduced internodal length, have been considered responsible, at least in part, for the age-related decrease in nerve conduction velocity. Reductions in peripheral efferent and afferent axon action potential conduction velocity have been often reported in the literature [82,[87][88][89][90][91]. Rivner et al [92] demonstrated that advancing age highly correlates with variations of nerve conduction velocity and both motor and sensory responses.…”