Impact of aging on human salivary gland function: A community-based study

Yeh, Chih Ko; Johnson, D. A.; Dodds, Michael

doi:10.1007/bf03339889

Cited by 101 publications

(111 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Some studies have reported no change in salivary flow rate after menopause [13,14], while other studies have shown lower flow rates in pregnant and postmenopausal women [2,3,15]. It has also been suggested that ageing may lead to a decrease in salivary flow rate as a consequence of parenchymal atropHy [16]. Alternatively, some authors showed that healthy old people had a normal salivary flow rate with a great functional reserve, mainly in the parotid glands [13].…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of the Effect of Menstruation, Pregnancy and Menopause on Salivary Flow Rate, pH and Gustatory Function

Saluja

Shetty

Dave

et al. 2014

JCDR

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of the Effect of Menstruation, Pregnancy and Menopause on Salivary Flow Rate, pH and Gustatory Function

Saluja

Shetty

Dave

et al. 2014

JCDR

View full text Add to dashboard Cite

“…One possible explanation for this difference is that salivary glands are continuing to develop through adolescence, with the highest salivary flow rates occurring during this time and young adulthood (Söderling et al, 1993;Yeh et al, 1998). Variations across individuals in the timing of development might lead to a greater range of flow rates in adolescents than in adults.…”

Section: Discussionmentioning

confidence: 99%

“…We compared saliva cotinine concentration with plasma cotinine concentration in heavily dependent adolescent cigarette smokers. Further, previous research on salivary flow rate and nicotine metabolism has shown variability across gender, ethnicity, and age which may impact the relationship of saliva and plasma cotinine concentrations (Berlin et al, 2007;Johnstone et al, 2006;Moolchan et al, 2006;Söderling et al, 1993;Yeh et al, 1998). Thus, we conducted a secondary analysis to examine potential differences in gender, ethnicity, and age.…”

Section: Introductionmentioning

confidence: 98%

Measuring nicotine intake among highly-dependent adolescent smokers: Comparability of saliva and plasma cotinine concentrations

Parzynski

Jaszyna-Gasior

Franken

et al. 2008

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Cotinine is the most common biomarker used to assess nicotine exposure and abstinence. It can be measured in various matrices including saliva, plasma, and urine. Previous research with adults has shown high correlations between saliva and plasma cotinine concentrations. However, research has not examined this relationship in adolescents. Additionally, variability in saliva flow and metabolism across gender, ethnicity, and age may impact the relationship between saliva and plasma cotinine concentration. Our aim was to examine the relationship between saliva and plasma cotinine concentration in a group of nicotine-dependent adolescent smokers. Additionally, we examined these correlations across gender, ethnicity and age. The sample consisted of 66 adolescent smokers (age 15.1 ± 1.3, 63.6% girls, 66.7% European American, CPD 18.3 ± 8.5, FTND 7.1 ± 1.3). Saliva and plasma specimens were collected before the treatment phase of a nicotine replacement therapy trial and analyzed. The relationship between saliva and plasma cotinine concentration was analyzed using Pearson's correlation coefficients. We performed a secondary analysis using multiple regression to compare correlations across race, gender and age. Results indicated a positive correlation between saliva cotinine and plasma cotinine concentration (r = .84, p < .001). Differences in correlations across age were significant (t = 3.03, p < .01). Differences across ethnicity approached significance (t = −1.93, p = .058). Future research should seek to further validate saliva-to-plasma cotinine concentration ratios in adolescents as well as characterize saliva-to-plasma concentration differences and their underlying mechanisms.

show abstract

“…Salivary flow has been reported to both decrease [10,11] and not decrease with age [12,13]. An epidemiological survey in Europe and America found that approximately 25% of the population was aware of xerostomia or dry mouth syndrome [14], while in Japan, an estimated 8million to 30 million patients are known to be unaware [15].…”

Section: Introductionmentioning

confidence: 99%