Impact of aging on calcium influx and potassium channel characteristics of T lymphocytes

Kollár, Szonja; Berta, László; Vásárhelyi, Zsófia; Balog, Attila; Vásárhelyi, Barna; Rigó, János; Toldi, Gergely

doi:10.18632/oncotarget.3808

Cited by 9 publications

(7 citation statements)

References 30 publications

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“…Further alterations concern a compromised response to the oxidative stress, that causes an increased susceptibility to damage-induced cell death [ 36 ], and calcium flow kinetics [ 37 ]. Recently it has been associated with the senescence a reduction of Mir 181 (MicroRNA precursor), that in T cell causes an impairment in the antigen recognition [ 38 ].…”

Section: Hematopoietic Bone and Thymusmentioning

confidence: 99%

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

et al. 2017

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BackgroundThe immunosenescence is a relatively recent chapter, correlated with the linear extension of the average life began in the nineteenth century and still in progress. The most important feature of immunosenescence is the accumulation in the “immunological space” of memory and effector cells as a result of the stimulation caused by repeated clinical and subclinical infections and by continuous exposure to antigens (inhalant allergens, food, etc.). This state of chronic inflammation that characterizes senescence has a significant impact on survival and fragility. In fact, the condition of frail elderly occurs less frequently in situations characterized by poor contact with viral infections and parasitic diseases. Furthermore the immunosenescence is characterized by a particular “remodelling” of the immune system, induced by oxidative stress. Apoptosis plays a central role in old age, a period in which the ability of apoptosis can change. The remodelling of apoptosis, together with the Inflammaging and the up-regulation of the immune response with the consequent secretion of pro-inflammatory lymphokines represents the major determinant of the rate of aging and longevity, as well as of the most common diseases related with age and with tumors. Other changes occur in the innate immunity, the first line of defence providing rapid, but unspecific and incomplete protection, consisting mostly of monocytes, natural killer cells and dendritic cells, acting up to the establishment of a adaptive immune response, which is slower, but highly specific, which cellular substrate consists of T and B lymphocytes. The markers of “Inflammaging” in adaptive immunity in centenarians are characterized by a decrease in T cells “naive.” The reduction of CD8 virgins may be related to the risk of morbidity and death, as well as the combination of the increase of CD8+ cells and reduction of CD4+ T cells and the reduction of CD19+ B cells. The immune function of the elderly is weakened to due to the exhaustion of T cell-virgin (CD95−), which are replaced with the clonal expansion of CD28-T cells.ConclusionsThe increase of pro-inflammatory cytokines is associated with dementia, Parkinson’s disease, atherosclerosis, diabetes type 2, sarcopenia and a high risk of morbidity and mortality. A correct modulation of immune responses and apoptotic phenomena can be useful to reduce age-related degenerative diseases, as well as inflammatory and neoplastic diseases.

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Section: Hematopoietic Bone and Thymusmentioning

confidence: 99%

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

et al. 2017

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“…Altered lymphocyte potassium channel inhibitory patterns, regulators of calcium influx kinetics, might contribute to the development of age-related changes of T cell function (Kollar et al 2015). It also presents a reduction of membrane receptors such as CD28 (important in lymphocyte activation) and CD27 (limited proliferative capacity by T lymphocytes) (Vallejo 2005, Parish et al 2009, Warrington et al 2003, FerrandoMartinez et al 2011, Cao et al 2010.…”

mentioning

confidence: 99%

Immune System Dysfunction in the Elderly

Fuentes

Alarcón

et al. 2017

An. Acad. Bras. Ciênc.

184

147

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Human aging is characterized by both physical and physiological frailty that profoundly affects the immune system. In this context aging is associated with declines in adaptive and innate immunity established as immunosenescence. Immunosenescence is a new concept that reflects the age-associated restructuring changes of innate and adaptive immune functions. Thus elderly individuals usually present chronic lowlevel inflammation, higher infection rates and chronic diseases. A study of alterations in the immune system during aging could provide a potentially useful biomarker for the evaluation of immune senescence treatment. The immune system is the result of the interplay between innate and adaptive immunity, yet the impact of aging on this function is unclear. In this article the function of the immune system during aging is explored.

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“…On the surface of immune cells, a variety of ion channel subtypes are displayed. K V 1.3 are the most well-described potassium channel subtype involved in the inflammation process and their dysfunction is associated to altered T function, through impacting the calcium influx and contributing to age-related changes of T cell function (Kollár et al, 2015).…”

Section: Role Of Mitochondria In the Regulation Of Inflamm-agingmentioning

confidence: 99%

Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging

et al. 2019

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Aging is often associated with a loss of function. We believe aging to be more an adaptation to the various, and often continuous, stressors encountered during life in order to maintain overall functionality of the systems. The maladaptation of a system during aging may increase the susceptibility to diseases. There are basic cellular functions that may influence and/or are influenced by aging. Mitochondrial function is amongst these. Their presence in almost all cell types makes of these valuable targets for interventions to slow down or even reserve signs of aging. In this review, the role of mitochondria and essential physiological regulators of mitochondria and cellular functions, ion channels, will be discussed in the context of human aging. The origins of inflamm-aging, associated with poor clinical outcomes, will be linked to mitochondria and ion channel biology.

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Impact of aging on calcium influx and potassium channel characteristics of T lymphocytes

Cited by 9 publications

References 30 publications

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

Immunosenescence in aging: between immune cells depletion and cytokines up-regulation

Immune System Dysfunction in the Elderly

Relationships Between Ion Channels, Mitochondrial Functions and Inflammation in Human Aging

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