Impact of aging on bone, marrow and their interactions

Hoffman, Corey M.; Han, Jimin; Calvi, Laura M.

doi:10.1016/j.bone.2018.07.012

Cited by 20 publications

(16 citation statements)

References 103 publications

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“…With increase in the age, osteoblast number, and activity decrease; while osteoclast number and activity increases leading to osteopenia and, in severe situations, osteoporosis. Oestrogen loss resulted in an increased bone resorption in postmenopausal women due to the stimulation of osteoclastogenesis 11 .…”

Section: Bone Health Status and Prevalence Ofmentioning

confidence: 99%

Untitled

2020

IJPSR

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Background: Diabetic postmenopausal women and osteoporosis are both chronic conditions and the relationship between them are complex. Objective: The aims of this study were to assess the socio-demographic factors inflicted in Diabetic postmenopausal women with Osteoporosis condition. Method: A Prospective, comparative and interventional study with a convenient sample of 520 Diabetic postmenopausal subjects were recruited from both inpatient and outpatient: Orthopedic, General Medicine and Obstetrics and Gynecology departments in Malla Reddy Hospital, measuring Bone Mineral Density (BMD) at the heel bone using QUS. In addition, tabulated selfreported data forms, about the socio-demographic details of subjects were collected. Results: The QUS measurements at the culmination of the study deduced that 520 Diabetic postmenopausal women posed a high risk of anomalous BMD were 17% (n=89), whereas Low risk of anomalous BMD accounted for 61% (n=317) and No risk accounted for 22% (n=114), out of validated subjects. The socio-demographic and osteoporotic conditions were illustrated. There were significant differences in QUS-score (normal BMD, Osteopenia and osteoporosis) patient demographic details like current age, age at menopause, Menopausal duration, BMI, Occupation, Family history of osteoporosis, Family history of Fracture, Smoking habit, Alcohol habit, economic status, and education details were noted. Conclusion: The study emphasizes the prerequisites , namely risk factor identification and evaluation, strive for the decreased incidence of Osteoporosis. It also denotes the Health education programs to be an utmost desideratum amongst the population for Osteoporosis management.

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Section: Bone Health Status and Prevalence Ofmentioning

confidence: 99%

Untitled

2020

IJPSR

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“…These signals include leptin, TNF-α, eotaxin, interferon-γ, vascular cell adhesion molecule-1 (VCAM-1), IFN-β, IL-4, and monocyte chemotactic protein (MCP-1). This may lead to reactive oxidative stress, NFκB activation, and a positive feedback loop that promotes inflammation and possibly malignancy in the aged mammal [71,136,137]. Just as MDS HSPCs may be subject to pyroptosis, HSPCs from elderly humans have similar tendencies with overexpression of the purinergic receptor P2X7 which activates and cleaves caspase-1 [11].…”

Section: Cellular Inflammatory Mediators In Mdsmentioning

confidence: 99%

Flaming and fanning: The Spectrum of inflammatory influences in myelodysplastic syndromes

Banerjee

Calvi²,

Becker³

et al. 2019

Blood Reviews

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The myelodysplastic syndromes (MDS) represent neoplasms derived from the expansion of mutated clonal hematopoietic cells which often demonstrate aberrant differentiation potential with resultant cytopenias and a propensity to evolve into acute myelogenous leukemia. While multiple mutations have been identified which may serve as drivers of the MDS clone, there is accumulating evidence that MDS clones and subclones are subject to modulation by the marrow microenvironment and its inflammatory milieu. There is also a strong link between autoimmune disorders and MDS. In this review, we examine the role of inflammatory cytokines, toll like receptors, pyroptosis, stromal cells, and cellular inflammatory mediators in MDS initiation, propagation, and progression. These contributions in a background of mutational, epigenetic, and aging changes in the marrow are also reviewed. Such inflammatory mediators may be subject to therapeutic agents which will enhance suppression of the MDS clone with potential to improve therapeutic outcomes in this disease which is usually incurable in aged patients not eligible for stem cell transplantation.

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“…It is presumed that protein synthesis and degradation are not well balanced in elderly patients[7], which increases risk of fall-related injury. Loss of bone density and muscle volume, known as osteoporosis and sarcopenia, respectively, significantly affect the general condition of elderly patients[39-41]. Primary sarcopenia is a decrease in muscle mass associated with aging, while secondary sarcopenia is a decrease in muscle mass and muscle strength associated with underlying diseases such as liver diseases, malignant tumors, and inflammatory diseases[42].…”

Section: Liver Cirrhosis In Elderly Patientsmentioning

confidence: 99%

Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients

Kamimura

Sakamaki

Kamimura

et al. 2019

WJG

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The aging of the organ function causes sensitivity to the disease progression and need careful consideration for the medical treatment. With the increase of aging population, the opportunity to provide medical treatment for people in very old age is rapidly increasing therefore, the understanding of the various physiological changes of cellular function, size and function of organs are essential for the decision of therapeutic options. Among the various chronic conditions seen in elderly people, we have focused on liver cirrhosis, since despite specific therapeutic options for many of liver diseases including direct acting antivirals for hepatitis C virus, nucleoside analogs for hepatitis B, and corticosteroids for autoimmune hepatitis, there is currently no standard therapy to treat liver cirrhosis, which is the final stage of these liver diseases. Therefore, management of the various symptoms of liver cirrhosis is essential, and aging-related parameters must be considered in the decision making for therapeutic strategies and dosage of the available medicine. In this mini-review, we have summarized the therapeutic options to manage various symptoms of liver cirrhosis, carefully considering the physiological changes of various organs associated with aging.

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Impact of aging on bone, marrow and their interactions

Cited by 20 publications

References 103 publications

Untitled

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Flaming and fanning: The Spectrum of inflammatory influences in myelodysplastic syndromes

Considerations of elderly factors to manage the complication of liver cirrhosis in elderly patients

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