Impact of age-related changes in serotonin and norepinephrine metabolism on reproductive function in female rats: An analytical review

Walker, Richard F.

doi:10.1016/0197-4580(84)90042-3

Cited by 24 publications

(6 citation statements)

References 157 publications

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“…It has been shown by others that pCPA can block the pro-oestrous surges of prolactin and LH (Walker & Wilson, 1983;Horn & Fink, 1985) and also the surges of both hormones induced by administration of oestrogen or oestrogen plus progest¬ erone to chronically ovariectomized rats (Caligaris & Taleisnik, 1974;Coen & McKinnon, 1979;Iyengar & Rabii, 1983;Walker & Wilson, 1983;Meyer &Eadens, 1985). This effect of pCPA seems to be mediated by serotonin depletion or by the disappearance of the daily rhythm of serotonin (Walker & Wilson, 1983;Walker, 1984). The effect of pCPA on the surges of prolactin at pro-oestrus or in oestrogen-primed ovari¬ ectomized rats was also reversed by administration of 5-hydroxytryptophan, which restored serotonin syn¬ thesis (Caligaris & Taleisnik, 1974).…”

Section: Discussionmentioning

confidence: 96%

“…2). It has been shown that progesterone can restore serotonin synthesis and cir¬ cadian rhythms in serotonin concentration in pCPAtreated rats (Walker & Wilson, 1983;Walker, 1984).…”

Section: Discussionmentioning

confidence: 99%

“…Thus, at this stage of pregnancy, progesterone has an inhibitory effect on prolactin release (Vermouth & Deis, 1972Bussmann & Deis, 1979;Bussmann, Koninckx & Deis, 1983). It has been shown that progesterone stimulates serotonin synthesis in the hypothalamus of rats (Munaro, 1978;Walker & Wilson, 1983;Walker, 1984). The aim of the present work was to assess the involvement of serotonin in the regulation of pro¬ lactin release by progesterone during pro-oestrus, when progesterone stimulates prolactin release, and during late pregnancy, when it is inhibitory.…”

mentioning

confidence: 94%

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A possible dual regulation of prolactin release by the serotoninergic system in rats at pro-oestrus and during late pregnancy: role of ovarian hormones

Jahn¹,

Deis²

1987

Journal of Endocrinology

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The effect of para-chlorophenylalanine (pCPA), an inhibitor of serotonin synthesis, on prolactin release was studied in rats on the day of pro-oestrus and at the end of pregnancy (day 19). The surges of prolactin normally seen in the afternoon of pro-oestrus in intact rats and in rats ovariectomized on dioestrous day 2 and primed with oestrogen were significantly inhibited by pCPA treatment. Administration of 5-hydroxytryptophan reversed the inhibitory action of pCPA on prolactin release. Treatment with progesterone also completely reversed the inhibitory effect of pCPA on prolactin release in pro-oestrous rats and partially reversed it in ovariectomized oestrogen-treated rats. Ovariectomy on day 19 of pregnancy induced a significant release of prolactin 12 and 24 h later. Administration of pCPA on day 18 of pregnancy produced a marked increase in serum concentrations of prolactin on days 19 and 20 in rats left intact or ovariectomized on day 19. Administration of 5-hydroxytryptophan significantly reversed this stimulatory effect of pCPA on prolactin release but did not modify the release of prolactin induced by ovariectomy. Methiothepin (1-[10,11-dihydro-8-(methylthio) less than b,f greater than thiepin-10,41]-4-methylpiperazine maleate), a serotonin receptor blocker, also induced a significant increase in serum concentrations of prolactin on day 20 of pregnancy in rats left intact or ovariectomized on day 19. These results suggest the existence of different serotoninergic actions in the regulation of prolactin release at pro-oestrus and in late pregnancy. Serotonin facilitates the surges of serum prolactin released at pro-oestrus and in ovariectomized rats treated with oestrogen; progesterone enhances this effect.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussionmentioning

confidence: 96%

“…2). It has been shown that progesterone can restore serotonin synthesis and cir¬ cadian rhythms in serotonin concentration in pCPAtreated rats (Walker & Wilson, 1983;Walker, 1984).…”

Section: Discussionmentioning

confidence: 99%

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confidence: 94%

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A possible dual regulation of prolactin release by the serotoninergic system in rats at pro-oestrus and during late pregnancy: role of ovarian hormones

Jahn¹,

Deis²

1987

Journal of Endocrinology

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“…The lack of effects from dopaminergic ergot alkaloids on PVC in old rodents contrasts with widely cited observations that L-dopa reinitiates cycling from PVC in old rats. We note possible reasons for this difference: (1) differences between central effects of L-dopa and of Hydergine and bromocriptine (Vigouret et al, 1978); (2) decreased central dopaminergic activity may not be the primary cause for the onset of PVC (Forman et al, 1980;Walker, 1984); (3) the doses may have been suboptimal, as suggested by the L-dopa dose-response relationship (Linnoila and Cooper, 1976) and the varying effectiveness of L-dopa reported in different studies (Finch. 1979); and (4) the small ovarian reserve in acyclic, middle-aged C57BL/6J.…”

Section: Hydergine Suppressed Age-related Spmentioning

confidence: 97%

Transient Shortening of Estrous Cycles in Aging C57BL/6J Mice: Effects of Spontaneous Pseudopregnancy, Progesterone, L-dihydroxyphenylalanine, and Hydergine1

Randall

Sinha

Ermini³

et al. 1987

Biology of Reproduction

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Regular estrous cycles can be reinitiated in old acyclic female rats by pharmacologic, hormonal, and environmental manipulations. The most responsive acyclic states are persistent vaginal cornification (PVC) and spontaneous pseudopregnancy (SP). However, it is not known if the irregular cyclicity that precedes acyclicity during aging can also be alleviated. We found that transient shortening of estrous cycles follows smear sequences indicative of pseudopregnancy in C57BL/6J mice, aged 9-15 mo, suggesting a role for progesterone. This phenomenon was investigated through a limited model of pseudopregnancy in which intact aging mice with lengthened cycles were given progesterone implants (yielding 70 ng progesterone/ml plasma) that suppressed estrous cycles; upon removal of the implants, cycles were transiently shortened in aging mice. Therefore, we hypothesize that withdrawal from the progesterone elevations associated with SP is the mechanism in shortening subsequent estrous cycles. Effects of central-acting drugs, similar to those used to reinitiate cyclicity in acyclic old rats, were also examined. Hydergine, an ergot mixture with partial dopaminergic and serotonergic agonist activities, suppressed SP when fed to 10- to 12-mo-old, middle-aged mice. Hydergine did not otherwise affect estrous cycle length, prevent PVC, or reinitiate cycling in acyclic PVC mice. Feeding L-dihydroxyphenylalanine to middle-aged mice did not suppress SP, affect estrous cycle lengths, or reinitiate cycles from PVC.

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“…Thus, it has been suggested that simple depletion of these germinal centers accounts for reproductive senescence in women (7 Figure 2. Presumably, altered gonadotropin release results ultimately from CNS perturbations affecting at least the metabolism and secretion of monoamines (10)(11)(12). In general terms, these changes are reciprocal between catecholamines and serotonin (13), ultimately shifting the nature of monoamine signals to the pituitary from catecholamines to those predominated by serotonin.…”

Section: Changes In Reproductive Function During Agingmentioning

confidence: 99%

Age Factors Potentiating Drug Toxicity in the Reproductive Axis

Walker¹

1986

Environmental Health Perspectives

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Impact of age-related changes in serotonin and norepinephrine metabolism on reproductive function in female rats: An analytical review

Cited by 24 publications

References 157 publications

A possible dual regulation of prolactin release by the serotoninergic system in rats at pro-oestrus and during late pregnancy: role of ovarian hormones

A possible dual regulation of prolactin release by the serotoninergic system in rats at pro-oestrus and during late pregnancy: role of ovarian hormones

Transient Shortening of Estrous Cycles in Aging C57BL/6J Mice: Effects of Spontaneous Pseudopregnancy, Progesterone, L-dihydroxyphenylalanine, and Hydergine1

Age Factors Potentiating Drug Toxicity in the Reproductive Axis

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