Impact of age on the survival of patients with liver cancer: an analysis of 27,255 patients in the SEER database

Abstract

Background & AimsThe risk of liver cancer (LC) is regarded as age dependent. However, the influence of age on its prognosis is controversial. The aim of our study was to compare the long-term survival of younger versus older patients with LC.MethodsIn this retrospective study, we searched Surveillance, Epidemiology, and End-Results (SEER) population-based data and identified 27,255 patients diagnosed with LC between 1988 and 2003. These patients were categorized into younger (45 years and under) and older age (over 45 years of age) groups. Five-year cancer specific survival data was obtained. Kaplan–Meier methods and multivariable Cox regression models were used to analyze long-term survival outcomes and risk factors.ResultsThere were significant differences between groups with regards to pathologic grading, histologic type, stage, and tumor size (p < 0.001). The 5-year liver cancer specific survival (LCSS) rates in the younger and older age groups were 14.5% and 8.4%, respectively (p < 0.001 by univariate and multivariate analysis). A stratified analysis of age on cancer survival showed only localized and regional stages to be validated as independent predictors, but not for advanced stages.ConclusionsCompared to older patients, younger patients with LC have a higher LCSS after surgery, despite the poorer biological behavior of this carcinoma.

The role of tumor grade, demographics and psychological factors in Cancer survivorship

“…With regard to the relationship between age and cancer survival, the study results are consistent with the study results by Zhang and Sun (36). As Zhang and Sun (2015) suggest cancer survival decreased with increasing age, and vice versa (36). Hence, this study confirmed the results of previous research in this field and develops new ideas.…”

“…This study developed the results of previous studies to predict survival of patients with cancer. With regard to the relationship between age and cancer survival, the study results are consistent with the study results by Zhang and Sun (36). As Zhang and Sun (2015) suggest cancer survival decreased with increasing age, and vice versa (36).…”

Down-Regulation of LncRNA DGCR5 Correlates with Poor Prognosis in Hepatocellular Carcinoma

“…70-90% of primary liver cancer is HCC, and about 50% of the total number of cases and deaths occurred in China. In the past decade, HCC incidence is increasing because of the rising incidence in Western Europe and Northern America [6,23,24]. In the USA, the incidence rate of HCC increased from 2.6 per 100,000 to 8.6 per 100,000 between 1975 and 2011 [1].…”

Effect of Tumor Size on Cancer-Specific Survival in Small Hepatocellular Carcinoma

“…[1][2][3] Although the incidence of LC is increasing rapidly in Asian countries, trends in LC have shown considerable increases in North America and Europe over the last few years. 4,5 The histology of primary LC can usually be classified as hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma, or combined HCC and intrahepatic cholangiocarcinoma.…”