Impact of age on FDG uptake in the liver on PET scan

Lin, Chun Yi; Ding, Hueisch‐Jy; Lin, Cheng Chieh; Chen, Cheng‐Chieh; Sun, Shung Shung; Kao, Chia Hung

doi:10.1016/j.clinimag.2009.11.003

Cited by 34 publications

(22 citation statements)

References 16 publications

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“…This positive correlation was also observed by Lin et al 16 On the contrary, there was a trend for a decrease in breast tumor SUV with increasing age, which did not reach statistical significance. In a previous study of 132 patients, we reported a significant negative correlation between patient age and breast tumor SUV.…”

Section: Discussionsupporting

confidence: 63%

Variation of Liver SUV on 18FDG-PET/CT Studies in Women With Breast Cancer

Groheux¹,

Delord²,

Rubello³

et al. 2013

Clinical Nuclear Medicine

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Section: Discussionsupporting

confidence: 63%

Variation of Liver SUV on 18FDG-PET/CT Studies in Women With Breast Cancer

Groheux¹,

Delord²,

Rubello³

et al. 2013

Clinical Nuclear Medicine

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“…Numerous authors have used SUV to compare the uptake of 18 F-FDG in lesions with that in normal liver [8][9][10]. However, recent studies have reported that liver 18 F-FDG uptake was vulnerable to variations in age, height, weight, BMI, glucose levels, hepatocellular steatosis, serologic liver enzymes, and serologic lipids [11][12][13][14][15][16][17][18][19][20]. However, recent studies have reported that liver 18 F-FDG uptake was vulnerable to variations in age, height, weight, BMI, glucose levels, hepatocellular steatosis, serologic liver enzymes, and serologic lipids [11][12][13][14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

The combined effects of serum lipids, BMI, and fatty liver on 18F-FDG uptake in the liver in a large population from China

Liu

Li²,

Hu³

et al. 2015

Nuclear Medicine Communications

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BMI, age, triglyceride, HDL, and apolipoprotein-A were independent variables predicting liver (18)F-FDG uptake. Mild and moderate degree of fatty liver had a positive effect on liver (18)F-FDG uptake, whereas a severe degree of fatty liver negatively affected (18)F-FDG uptake. Attention should be paid to liver metabolism in patients with fatty liver before using liver as the comparator in determining focal (18)F-FDG uptake elsewhere within the abdomen.

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“…This study demonstrated that a shorter delay results in higher background activity, which has been proven to reduce overall PET sensitivity and accuracy (17). Any loss of patient throughput by adopting a 90-min delay could be mitigated by appropriately staggering injection times.…”

Section: Discussionmentioning

confidence: 86%

Optimizing ¹⁸F-FDG Uptake Time Before Imaging Improves the Accuracy of PET/CT in Liver Lesions

Al-faham

Jolepalem

Rydberg

et al. 2016

J. Nucl. Med. Technol.

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Beaumont Health System, Royal Oak, Michigan 18 F-FDG PET/CT has emerged as one of the fastest-growing imaging modalities. A shorter protocol results in a lower targetto-background ratio, which can increase the challenge of identifying mildly 18 F-FDG-avid lesions and differentiating inflammatory or physiologic activity from malignant activity. The purpose of this study was to determine the delay between radiotracer injection and imaging that optimizes target-to-background ratio while maintaining counts high enough to ensure scan sensitivity. Methods: The study included 140 patients (66 male and 74 female; age range, 42-95 y) with suspected hepatic lesions as seen on an 18 F-FDG PET scan. SUV was determined as regionof-interest activity/(dose/total body weight). Results: The mean injected dose was 610 ± 66.6 MBq (16.5 ±1.8 mCi), with a mean glucose level of 107 ± 26.6 mg/dL (standardized to 90 mg/dL). The uptake time before imaging ranged from 61 to 158 min, with a mean of 108.8 ± 24.8 min. The P values for the correlation of SUV to time were 0.004, 0.003, and 0.0001 for malignant lesions, benign lesions, and background hepatic tissue, respectively. Conclusion: An approximately 90-min time window from 18 F-FDG injection to PET imaging would significantly improve target-to-background ratio and, thus, quantitation and visual interpretation. This benefit outweighs the minimal loss in patient throughput. Int egrated 18 F-FDG PET/CT has emerged as one of the fastest-growing imaging modalities. The recent expansion of coverage from the Centers for Medicare and Medicaid Services has made its use even more feasible for communitybased hospitals and independent imaging centers. To maximize throughput, many of these centers use a 50-to 60-min uptake time after 18 F-FDG injection while arguing that the counting statistics are improved using this protocol (1-3). However, this shorter protocol results in a lower targetto-background ratio, which can increase the challenge of identifying mildly 18 F-FDG-avid lesions and differentiating inflammatory or physiologic activity from malignant activity (4-6).The purpose of this study was to determine the delay between radiotracer injection and imaging that optimizes target-to-background ratio while maintaining counts high enough to ensure scan sensitivity. Hepatic lesions and background hepatic tissue were chosen as the test and control tissues because 18 F-FDG has a relatively predictable parabolic uptake pattern in the liver (7,8). Additionally, the heterogeneous or mottled appearance of the liver often presents a challenge during image interpretation by producing areas of benign focal uptake or masking uptake within a malignant lesion (6). MATERIALS AND METHODSThe study was approved by the human investigation committee at William Beaumont Hospital (study 2012-226). The population comprised 140 patients (66 male and 74 female; age range, 42-95 y) with suspected hepatic lesions as seen on an 18 F-FDG PET scan. All enrolled patients had a primary malignancy and either had been referred...

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Impact of age on FDG uptake in the liver on PET scan

Cited by 34 publications

References 16 publications

Variation of Liver SUV on 18FDG-PET/CT Studies in Women With Breast Cancer

Variation of Liver SUV on 18FDG-PET/CT Studies in Women With Breast Cancer

The combined effects of serum lipids, BMI, and fatty liver on 18F-FDG uptake in the liver in a large population from China

Optimizing ¹⁸F-FDG Uptake Time Before Imaging Improves the Accuracy of PET/CT in Liver Lesions

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Impact of age on FDG uptake in the liver on PET scan

Cited by 34 publications

References 16 publications

Variation of Liver SUV on 18FDG-PET/CT Studies in Women With Breast Cancer

Variation of Liver SUV on 18FDG-PET/CT Studies in Women With Breast Cancer

The combined effects of serum lipids, BMI, and fatty liver on 18F-FDG uptake in the liver in a large population from China

Optimizing 18F-FDG Uptake Time Before Imaging Improves the Accuracy of PET/CT in Liver Lesions

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Optimizing ¹⁸F-FDG Uptake Time Before Imaging Improves the Accuracy of PET/CT in Liver Lesions