Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury*

Leal-Noval, Santiago R.; Múñoz-Gómez, Manuel; Arellano-Orden, Victoria; Marín-Caballos, Antonio; Amaya-Villar, Rosario; Marín, Ana Isabel; Puppo-Moreno, Antonio; Ferrándiz-Millón, Carmen; Flores-Cordero, J.M.; Murillo-Cabezas, Francisco

doi:10.1097/ccm.0b013e3181692dfc

Cited by 147 publications

(151 citation statements)

References 21 publications

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“…The authors report that: "There was a significant short-lasting (3-4 hrs) increase in pbtO2 values after transfusion of erythrocytes stored for <10 days, 10-14 days, or 15-19 days, compared with those at baseline. In contrast, no significant changes in pbtO2 were observed after transfusion of erythrocytes stored >19 days" [136]. Similar findings have been confirmed elsewhere in an animal study [135].…”

Section: Anemiasupporting

confidence: 75%

See 1 more Smart Citation

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Lang

Jaeger²

2013

TOCCMJ

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This review has been compiled to assess publications related to the clinical application of direct cerebral tissue oxygenation (pbtO2) monitoring published in international, peer-reviewed scientific journals, or major meeting reports published as journal supplements. Its goal was to extract relevant, i.e. positive and negative, information on indications, clinical application, safety issues and impact on clinical situations, as well as treatment strategies in neurosurgery, neurosurgical anaesthesiology, neurosurgical intensive care, neurology, and related specialties. For completeness' sake it also presents related basic science research and case reports. This review is an update of its previous edition published elsewhere in 2007. This review reflects publications from 2004 to 2012. Only relevant publications prior to 2004, which explicitly addressed or systematically examined the above issues, are included in this review and are listed in the reference section. Based on 349 citations it is the most comprehensive review available on direct cerebral oxygen monitoring to this date.Keywords: Review, cerebral oxygenation, raumedic, licox, neurotrend, cerebral partial pressure of oxygen, brain tissue oxygenation. METHODSThis review is based on a systematic "Medline" literature search using the following search terms: licox, neurotrend, neurovent, raumedic, brain tissue oxygen, brain tissue oxygenation, cerebral oxygenation, cerebral tissue oxygen, cerebral partial pressure of oxygen, btO2, ptiO2, pti(O)2, ptiO(2), pbrO2, PBr(O2), P(bt)O(2), P(br)O(2), PbrO(2), BTpO2, tP(O2), PbO2, PbtO2, Pbto, PbtO(2).Only few publications were not retrieved using this technique. They were, however, identified through personal communication with scientists in the field, meeting proceedings and reviewer assignments. This strategy provided sufficient certainty that relevant papers have not been missed. Unpublished meeting abstracts and published conference proceedings were excluded for this review expect for few which provided comparative studies between different probes. To address relevant matters, related to specific pbtO2 issues, selected non-peer reviewed papers published in supplements were also used only when no other peer-reviewed information was available. RESULTSThis review is based on a previous review [1]. It is currently based on 349 papers, 274 more papers compared to its previous version in 2007, which warrants the update.

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Section: Anemiasupporting

confidence: 75%

“…The aspect of storage duration of RPBC on the effects of pbtO2 has been studied in 66 anaemic male TBI patients [136]. The authors report that: "There was a significant short-lasting (3-4 hrs) increase in pbtO2 values after transfusion of erythrocytes stored for <10 days, 10-14 days, or 15-19 days, compared with those at baseline.…”

Section: Anemiamentioning

confidence: 91%

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Lang

Jaeger²

2013

TOCCMJ

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“…Three months later, Leal-Noval and his colleagues reported on a study of transfusion in brain-injured patients with brain tissue oxygen electrodes implanted in the side contralateral to the injury [56]. They reported that BtPO 2 did not improve in male patients after transfusion of red blood cell units stored longer than 19 days.…”

Section: Data From Clinical Studiesmentioning

confidence: 99%

Current issues relating to the transfusion of stored red blood cells

Zimrin¹,

2009

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The development of blood storage systems allowed donation and transfusion to be separated in time and space. This separation has permitted the regionalization of donor services with subsequent economies of scale and improvements in the quality and availability of blood products. However, the availability of storage raises the question of how long blood products can and should be stored and how long they are safe and effective. The efficacy of red blood cells was originally measured as the increment in haematocrit and safety began with typing and the effort to reduce the risk of bacterial contamination. Appreciation of a growing list of storage lesions of red blood cells has developed with our increasing understanding of red blood cell physiology and our experience with red blood cell transfusion. However, other than frank haemolysis, rare episodes of bacterial contamination and overgrowth, the reduction of oxygen-carrying capacity associated with the failure of some transfused cells to circulate, and the toxicity of lysophospholipids released from membrane breakdown, storage-induced lesions have not had obvious correlations with safety or efficacy. The safety of red blood cell storage has also been approached in retrospective epidemiologic studies of transfused patients, but the results are frequently biased by the fact that sicker patients are transfused more often and blood banks do not issue blood products in a random order. Several large prospective studies of the safety of stored red blood cells are planned.

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“…10 Despite that, universal blood transfusion triggers continue to be controversial, and there is evidence to suggest that "dosing" blood by unit(s) as opposed to absolute hematocrit targets may be more prudent in the context of brain tissue oxygenation. [11][12][13] The age of the transfused blood may also be an important consideration, with more favorable cerebral oxygenation responses seen following transfusions of blood stored for fewer than 19 days. 11 Therapy directed at correcting hypovolemic shock includes prompt volume expansion with crystalloid solutions, followed by administration of blood products as per established trauma guidelines.…”

mentioning

confidence: 99%

“…[11][12][13] The age of the transfused blood may also be an important consideration, with more favorable cerebral oxygenation responses seen following transfusions of blood stored for fewer than 19 days. 11 Therapy directed at correcting hypovolemic shock includes prompt volume expansion with crystalloid solutions, followed by administration of blood products as per established trauma guidelines. It is hypothesized that, following traumatic brain injury, cerebrovascular dysfunction results in loss of brain compliance, resulting in increased sensitivity to elevated venous pressures.…”

mentioning

confidence: 99%

Competing Priorities in the Brain Injured Patient: Dealing with the Unexpected

Wisler¹,

Beery²,

Steinberg³

et al. 2012

Brain Injury - Pathogenesis, Monitoring, Recovery and Management

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Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury*

Abstract: Transfusion of erythrocytes increased cerebral oxygenation in patients with severe traumatic brain injury, except in those transfused with erythrocytes stored >19 days.

Cited by 147 publications

References 21 publications

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Systematic and Comprehensive Literature Review of Publications on Direct Cerebral Oxygenation Monitoring

Current issues relating to the transfusion of stored red blood cells

Competing Priorities in the Brain Injured Patient: Dealing with the Unexpected

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