Impact of age at diagnosis of head and neck cancer on incidence of metachronous cancer

Abstract

BackgroundMetachronous cancer in patients with head and neck cancer (HNC) is common and is associated with a poor prognosis. We aimed to evaluate the incidence of metachronous cancer at different sites according to age at diagnosis of index HNC.MethodsWe collected data on 2011 patients with oral cancer, oropharynx cancer, hypopharyngeal cancer, and laryngeal cancer as index cancers using the Osaka International Cancer Institute Cancer Registry database between 2005 and 2016. Among these, we analyzed 1953 patients after excluding 5 patients who were not followed-up and 53 patients with simultaneous multiple index cancers. We evaluated the cumulative incidence of metachronous cancer in the esophagus, lung, and other sites according to age at diagnosis of the index HNC using the Kaplan–Meier method. Multivariate logistic regression analysis was performed to identify factors that influenced the incidence of metachronous cancers following HNC.ResultsThe cumulative incidence of metachronous esophageal cancer in young patients (< 65 years) was significantly higher than that in old patients (≥ 65 years) (12.1% vs 8.5% at 5 years, and 16.5% vs 11.2% at 10 years; p = 0.015). On the other hand, the cumulative incidence of the other cancers in young patients was significantly lower than that in old patients (7.8% vs 12.2% at 5 years, and 13.9% vs 15.3% at 10 years; p = 0.017). The cumulative incidence of lung cancer was not significance according to age at diagnosis of the index HNC. In the multivariate analysis, histological type (squamous cell carcinoma) and lesion location (hypopharynx and larynx) were independently associated with metachronous cancers. Moreover, age at diagnosis of the index HNC (< 65 years), histological type (squamous cell carcinoma) and lesion location (hypopharynx) were significant predictors of metachronous esophageal cancer incidence and lesion location (hypopharynx) was a significant predictor of metachronous lung cancer incidence.ConclusionRisk stratification of metachronous cancers with age and other predictors may help to properly manage patients with HNC.Trial registrationThe present study is a non-intervention trial.

Endoscopic Surveillance for Metachronous Esophageal Squamous Cell Neoplasms among Head and Neck Cancer Patients

“…Fukuhara et al retrospectively analyzed 135 patients with primary HNSCC and found that multiple LVLs were significantly associated with the development of metachronous ESCC [ 10 ]. There were two retrospective studies that used big data analysis for the risk of head and neck cancer patients to develop metachronous ESCN in Japan and Taiwan [ 15 , 16 ]. In Japan, Iwatsubo et al used the Osaka International Cancer Institute Cancer Registry database and retrospectively recruited 1953 head and neck patients between 2005 and 2016 [ 15 ].…”

“…There were two retrospective studies that used big data analysis for the risk of head and neck cancer patients to develop metachronous ESCN in Japan and Taiwan [ 15 , 16 ]. In Japan, Iwatsubo et al used the Osaka International Cancer Institute Cancer Registry database and retrospectively recruited 1953 head and neck patients between 2005 and 2016 [ 15 ]. Younger patients (age < 65 years), histological type (squamous cell carcinoma), and primary lesion location (hypopharynx) were significant risk factors for head and neck cancer patients to develop metachronous ESCNs [ 15 ].…”

“…In Japan, Iwatsubo et al used the Osaka International Cancer Institute Cancer Registry database and retrospectively recruited 1953 head and neck patients between 2005 and 2016 [ 15 ]. Younger patients (age < 65 years), histological type (squamous cell carcinoma), and primary lesion location (hypopharynx) were significant risk factors for head and neck cancer patients to develop metachronous ESCNs [ 15 ]. In addition to HNSCC (95.4%), they recruited participants with other malignancies in the head and neck, such as lymphoma and melanoma, which was different from our study, where only HNSCC patients were recruited.…”

Assessment of the gustatory function in patients with advanced oral cavity and oropharyngeal cancer

“…The males and the age range from 45 to 69 years represent a world prevalence of affection with oral cavity and oropharyngeal cancer (15,16) . The data found in this study corroborate such findings.…”

Diagnostic Problems Accompanying Branhyogenic Cancer – A Clinical Case

“…Some authors argue that the diagnosis of BC bears a theoretical and hypothetical character. Thus, the diagnosis itself remains controversial up to the present day [20,21].…”