Impact of age and sex on the incidence and prevalence of psoriatic arthritis

Egeberg, Alexander; Kristensen, Lars Erik

doi:10.1136/annrheumdis-2017-211980

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…A similar increase in the proportion of women was also noted in Denmark (21) and Taiwan (22). Moreover, a similar increase in incidence in women ages 40–59 years was observed in Denmark (23). In Israel, however, both sexes had a similar degree of increase in incidence over time (years 2006–2015) (18).…”

Section: Discussionsupporting

confidence: 72%

The Epidemiology of Psoriatic Arthritis Over Five Decades: A Population‐Based Study

Karmacharya

Crowson

Bekele

et al. 2021

Arthritis & Rheumatology

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Objective To determine the incidence of psoriatic arthritis (PsA) in a US population and describe trends in incidence and mortality over 5 decades. Methods The previously identified population‐based cohort that included Olmsted County, Minnesota residents ≥18 years of age who fulfilled PsA criteria during 1970–1999 was extended to include patients with incident PsA during 2000–2017. Age‐ and sex‐specific incidence rates and point prevalence, adjusted to the 2010 US White population, were reported. Results There were 164 incident cases of PsA in 2000–2017 (mean ± SD age 46.4 ± 12.0 years; 47% female). The overall age‐ and sex‐adjusted annual incidence of PsA per 100,000 population was 8.5 (95% confidence interval [95% CI] 7.2–9.8) and was higher in men (9.3 [95% CI 7.4–11.3]) than women (7.7 [95% CI 5.9–9.4]) in 2000–2017. Overall incidence was highest in the 40–59 years age group. The incidence rate was relatively stable during 2000–2017, with no evidence of an overall increase or an increase in men only (but a modest increase of 3% per year in women), compared to 1970–1999 when a 4%‐per‐year increase in incidence was observed. Point prevalence was 181.8 per 100,000 population (95% CI 156.5–207.1) in 2015. The percentage of women among those with PsA increased from 39% in 1970–1999 and 41% in 2000–2009 to 54% in 2010–2017 (P = 0.08). Overall survival in PsA did not differ from the general population (standardized mortality ratio 0.85 [95% CI 0.61–1.15]). Conclusion The incidence of PsA in this predominantly White US population was stable in 2000–2017, in contrast to previous years. However, an increasing proportion of women with PsA was found in this study.

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Section: Discussionsupporting

confidence: 72%

The Epidemiology of Psoriatic Arthritis Over Five Decades: A Population‐Based Study

Karmacharya

Crowson

Bekele

et al. 2021

Arthritis & Rheumatology

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“…In this article, we demonstrate that it is also possible to estimate excess mortality from age-specific prevalence and incidence of a chronic disease. This can be useful for the analysis of data where it is difficult to observe mortality directly, for instance in disease registers [4] or health insurance claims data where cases of death might be reported with a delay [5]. Another example where excess mortality of a chronic condition cannot be estimated directly is the US National Health Interview Survey (NHIS) from the National Center for Health Statistics [6].…”

Section: Introductionmentioning

confidence: 99%

New ways of estimating excess mortality of chronic diseases from aggregated data: insights from the illness-death model

2019

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Background Recently, we have shown that the age-specific prevalence of a disease can be related to the transition rates in the illness-death model via a partial differential equation (PDE). The transition rates are the incidence rate, the remission rate and mortality rates from the ‘Healthy’ and ‘Ill’ states. In case of a chronic disease, we now demonstrate that the PDE can be used to estimate the excess mortality from age-specific prevalence and incidence data. For the prevalence and incidence, aggregated data are sufficient - no individual subject data are needed, which allows application of the methods in contexts of strong data protection or where data from individual subjects is not accessible. Methods After developing novel estimators for the excess mortality derived from the PDE, we apply them to simulated data and compare the findings with the input values of the simulation aiming to evaluate the new approach. In a practical application to claims data from 35 million men insured by the German public health insurance funds, we estimate the population-wide excess mortality of men with diagnosed type 2 diabetes. Results In the simulation study, we find that the estimation of the excess mortality is feasible from prevalence and incidence data if the prevalence is given at two points in time. The accuracy of the method decreases as the temporal difference between these two points in time increases. In our setting, the relative error was 5% and below if the temporal difference was three years or less. Application of the new method to the claims data yields plausible findings for the excess mortality of type 2 diabetes in German men. Conclusions The described approach is useful to estimate the excess mortality of a chronic condition from aggregated age-specific incidence and prevalence data. Trial registration The article does not report the results of any health care intervention. Electronic supplementary material The online version of this article (10.1186/s12889-019-7201-7) contains supplementary material, which is available to authorized users.

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“…We are grateful to Egeberg and Kristensen for presenting the detailed data about the prevalence and incidence of psoriatic arthritis (PsA) 1. Based on these detailed information, we tried to estimate the excess mortality of people with diagnosed PsA by uising a mathematical relation between incidence, prevalence and mortality 2 3.…”

mentioning

confidence: 99%

“…where ∂p is the temporal change of the age-specific prevalence p with respect to time and age 1 2. The rates i, m0 and m1 are the age-specific incidence and mortality rates of the people with (m1) and without diagnosed PsA (m0).…”

mentioning

confidence: 99%

Inconsistency between Danish incidence and prevalence data about psoriatic arthritis (PsA)

et al. 2018

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Impact of age and sex on the incidence and prevalence of psoriatic arthritis

Cited by 4 publications

References 2 publications

The Epidemiology of Psoriatic Arthritis Over Five Decades: A Population‐Based Study

The Epidemiology of Psoriatic Arthritis Over Five Decades: A Population‐Based Study

New ways of estimating excess mortality of chronic diseases from aggregated data: insights from the illness-death model

Inconsistency between Danish incidence and prevalence data about psoriatic arthritis (PsA)

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