Impact of age and sex on carotid and peripheral arterial wall thickness in humans

Munckhof, Inge van den; Scholten, Ralph R.; Cable, N. Timothy; Hopman, Maria T. E.; Green, Daniel; Thijssen, Dick H. J.

doi:10.1111/j.1748-1716.2012.02457.x

Cited by 30 publications

(30 citation statements)

References 32 publications

(34 reference statements)

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“…; van den Munckhof et al . ). Moreover, the magnitude of age‐related thickening seems comparable between central and peripheral arteries (van den Munckhof et al .…”

Section: Introductionmentioning

confidence: 97%

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Arterial structure and function in vascular ageing: are you as old as your arteries?

Thijssen

Carter

Green

2015

The Journal of Physiology

174

142

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Advancing age may be the most potent independent predictor of future cardiovascular events, a relationship that is not fully explained by time-related changes in traditional cardiovascular risk factors. Since some arteries exhibit differential susceptibility to atherosclerosis, generalisations regarding the impact of ageing in humans may be overly simplistic, whereas in vivo assessment of arterial function and health provide direct insight. Coronary and peripheral (conduit, resistance and skin) arteries demonstrate a gradual, age-related impairment in vascular function that is likely to be related to a reduction in endothelium-derived nitric oxide bioavailability and/or increased production of vasoconstrictors (e.g. endothelin-1). Increased exposure and impaired ability for defence mechanisms to resist oxidative stress and inflammation, but also cellular senescence processes, may contribute to age-related changes in vascular function and health. Arteries also undergo structural changes as they age. Gradual thickening of the arterial wall, changes in wall content (i.e. less elastin, advanced glycation end-products) and increase in conduit artery diameter are observed with older age and occur similarly in central and peripheral arteries. These changes in structure have important interactive effects on artery function, with increases in small and large arterial stiffness representing a characteristic change with older age. Importantly, direct measures of arterial function and structure predict future cardiovascular events, independent of age or other cardiovascular risk factors. Taken together, and given the differential susceptibility of arteries to atherosclerosis in humans, direct measurement of arterial function and health may help to distinguish between biological and chronological age-related change in arterial health in humans. Abbreviations AGE, advanced glycation end-products; CVD, cardiovascular disease; eNOS, endothelial nitric oxide synthase; ET-1, endothelin-1; FMD, flow mediated dilation; FRS, Framingham Risk Score; GTN, glyceryl trinitrate; IMT, intima-media thickness; L-NMMA, NG-monomethyl-L-arginine; NO, nitric oxide; sGC, soluble guanylyl cyclase; SNP, sodium nitroprusside. The work by Professors Dick H. J. Thijssen and Daniel J. Green aims to understand the impact of exercise training and physical (in)activity in the context of (primary and secondary) prevention of cardiovascular disease. Specifically, we adopt novel imaging approaches to assess the effects of exercise training on micro and macrovessel function and structure, and explore factors that moderate these effects (e.g. older age). These benefits of exercise training on the arterial wall may contribute to the reduction in cardiovascular risk. Furthermore, our work has strongly focused on understanding (haemodynamic) stimuli, such as shear stress and arterial pressure, to mediate the effects of exercise training on the vasculature. In our work we encompasses the lifespan; from exercise training in the prevention of the developmen...

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“…; van den Munckhof et al . ). Moreover, the magnitude of age‐related thickening seems comparable between central and peripheral arteries (van den Munckhof et al .…”

Section: Introductionmentioning

confidence: 97%

“…Moreover, the magnitude of age‐related thickening seems comparable between central and peripheral arteries (van den Munckhof et al . ). This is of particular importance, since the brachial artery is not considered atherosclerosis‐prone (van den Munckhof et al .…”

Section: Introductionmentioning

confidence: 97%

Arterial structure and function in vascular ageing: are you as old as your arteries?

Thijssen

Carter

Green

2015

The Journal of Physiology

174

142

View full text Add to dashboard Cite

show abstract

“…Subjects were examined in a supine position with the head turned 45° contralateral to the side of scanning. Intima-media thickness (IMT) was defined as the distance between the lumen-intima and the media-adventitia ultrasound interfaces and measured as the distance between the two parallel echogenic lines on the far wall of artery in longitudinal plane image frozen in the screen by electronic calipers [11]. The IMT on the far wall of the bilateral common carotid artery about 10mm proximal to the bifurcation of the carotid artery was measured manually as previously described [12].…”

Section: Methodsmentioning

confidence: 99%

Correlation of Lower Concentrations of Hydrogen Sulfide with Atherosclerosis in Chronic Hemodialysis Patients with Diabetic Nephropathy

Feng²,

Zhang³

et al. 2014

Blood Purif

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Background/Aims: To explore the relationship between hydrogen sulfide (H₂S) and uremic accelerated atherosclerosis (UAAS) in chronic hemodialysis patients with diabetic nephropathy (CHD/DN). Methods: A total of 36 CHD/DN and 32 chronic hemodialyzed non-diabetic patients with chronic glomerulonephritis (CHD/non-DN) were studied. Plasma H₂S was measured with a sulfide sensitive electrode. Results: Plasma H₂S in CHD/DN was significantly lower than that in CHD/non-DN patients. Plasma H₂S was positively correlated with plasma TGF-β1, and negatively correlated with MMP-12 in CHD/DN patients. CHD/DN patients exhibited higher CCA-IMT, hsCRP, and lower H₂S levels than in CHD/non-DN patients. Moreover, in CHD/DN patients, CCA-IMT was negatively correlated with plasma H₂S, and positively correlated with hsCRP and LDL. On multiple regression analysis, H₂S levels exhibited independent association with IMT in CHD/DN patients. Conclusions: These findings suggest possible linkage between H₂S metabolism and TGF-β/Smad signaling pathway modulation abnormalities that may contribute to the development of UAAS in CHD/DN patients.

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“…Arterial stiffness has been correlated with cardiovascular events and considered to be a major risk factor in aging, hypertension, diabetes mellitus and metabolic pathology (Van den Munckhof et al 2012). It is also an age-dependent alteration of the vascular wall that has been defined as an early vascular aging factor.…”

Section: Discussionmentioning

confidence: 99%

Echo-Tracking Technology Assessment of Carotid Artery Stiffness in Patients with Coronary Slow Flow

Yang

Wang

Zhang

et al. 2015

Ultrasound in Medicine & Biology

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Impact of age and sex on carotid and peripheral arterial wall thickness in humans

Cited by 30 publications

References 32 publications

Arterial structure and function in vascular ageing: are you as old as your arteries?

Arterial structure and function in vascular ageing: are you as old as your arteries?

Correlation of Lower Concentrations of Hydrogen Sulfide with Atherosclerosis in Chronic Hemodialysis Patients with Diabetic Nephropathy

Echo-Tracking Technology Assessment of Carotid Artery Stiffness in Patients with Coronary Slow Flow

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