Impact of age and gender on microvascular function

Schlager, Oliver; Giurgea, Aura; Hammer, Alexandra; Charwat-Resl, Silvia; Margeta, Christian; Mueller, Markus; Ehringer, Teresa; Zehetmayer, Sonja; Willfort-Ehringer, Andrea; Koppensteiner, Renate; Gschwandtner, Michael E.

doi:10.1111/eci.12293

Cited by 17 publications

(13 citation statements)

References 35 publications

(46 reference statements)

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“…We found that the hyperemic response to transient ischemia is greater and more prolonged in males than in females. It is well documented that gender has a significant impact on POHR readings not only in large arteries but also in the microcirculation of the skin . Our results suggest that in a challenged situation the vasodilator (FMD and ascending dilatation) capacity of the gingival vessels may be higher in males.…”

Section: Discussionmentioning

confidence: 49%

“…It is well documented that gender has a significant impact on POHR readings not only in large arteries [43][44][45] but also in the microcirculation of the skin. 46,47 Our results suggest that in a challenged situation the F I G U R E 8 Cumulated blood flow changes during a five-second interval (TOI2) of horizontal (A), vertical (B), and papilla base (C) compression and subsequently for twenty minutes (TOI3-7), grouped by gender. Perfusion values within a TOI were averaged.…”

Section: Discussionmentioning

confidence: 91%

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Functional characterization of collaterals in the human gingiva by laser speckle contrast imaging

et al. 2018

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Objective The rate of blood flow between the various areas of the gingiva in resting position and under challenge is unknown. In this study, the LSCI method was used to map spatial and temporal changes in gingival blood flow after transient compression. Methods Horizontal, vertical, and papilla base compressions were applied on the attached gingiva in 21 healthy patients (13 women, 8 men). LSCI was used to determine dynamic changes in regional blood flow during a five‐second occlusion interval and subsequent reperfusion for twenty minutes. Results Resting blood flow in the attached gingiva apical to the papillae was higher as compared to that in the midbuccal area of the teeth. During short‐term horizontal compression, ischemia was greater coronal than apical to the occlusion line. Postocclusive hyperemia was observed not only in the regions affected by ischemia but encompassed a wider area. Hyperemic response was more pronounced and prolonged in male than in female patients. Conclusions Blood flow in the attached gingiva shows spatial differences. Our findings corroborate the apicocoronal orientation of blood circulation. Periodontal and papillary collaterals may have little role in the blood supply of the adjacent attached gingiva under physiological conditions.

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Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 91%

Functional characterization of collaterals in the human gingiva by laser speckle contrast imaging

et al. 2018

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“…Concerning a gender impact on TiVi values, men showed significant higher TiVi values representing a higher subepidermal concentration of red blood cells and therefore a higher blood circulation than women. Previous studies have also observed such differences in microcirculation between both sexes . The gender impact on development of hand eczema is still under discussion.…”

Section: Discussionmentioning

confidence: 94%

“…Previous studies have also observed such differences in microcirculation between both sexes. 31,32 The gender impact on development of hand eczema is still under discussion. There are studies which indicate to a higher risk for women, but others did not.…”

Section: Discussionmentioning

confidence: 99%

The tissue viability imaging system—Suitable method for discovering minimal skin changes in occupational screenings? Results of a cross‐sectional field study

Weistenhöfer

Uter

Bernet

et al. 2019

Skin Research and Technology

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Background For early detection of initial skin changes in occupational screenings, only few objective assessment systems are available. Objectives With the aim of assessing an objective measurement method for hand eczema, we trialed the application of the tissue viability imaging (TiVi) system, quantifying erythema non‐invasively by polarized light spectroscopy. Materials and Methods In a field study with 625 employees of a semiconductor production company, 411 were exposed to prolonged wearing of occlusive gloves in the clean room. TiVi system and Hand Eczema Score for Occupational Screenings (HEROS), a quantitative skin score for the hands, were used, supplemented by a standardized personal interview. Results TiVi values of 65 up to 246 for each hand (palm or back), for each participant summed to overall 289 up to 848 (median 389), were measured. Higher TiVi values were noted for men, smokers, and with increasing age. Correlation between TiVi and HEROS was only weak. Several factors like skin pigmentation, thickness of the skin, or tattoos seem to influence TiVi results. Conclusions The practical relevance of one‐time measurements with the TiVi system in occupational screenings seems to be limited. Specifically, the TiVi system cannot replace dermatological examinations at the workplace. Notwithstanding, the application for other scientific purposes might be useful.

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“…A recent meta-analysis showed an overall neutral effect of COX inhibition on skin PORH [33], suggesting no involvement of prostanoids. PORH is inversely associated with age in children and adolescents [71], attenuated in smokers [63], and in hypertension in which it may be restored after antihypertensive therapy [62,74]. Similarly, statins have been shown to improve PORH in hypercholesterolemic patients [4] but not in central obesity [14].…”

Section: Postocclusive Reactive Hyperemiamentioning

confidence: 99%

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

2016

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Several noninvasive techniques have been developed using laser light interaction in the skin to explore the skin's microcirculation. Combined with laser Doppler or LSCI, reactivity tests are used to explore skin endothelial and neurovascular function in humans, including PORH, LTH, PIV, and iontophoresis of vasodilators. Recent advances in our comprehension of the physiological pathways underlying these reactivity tests have been possible through topical or intradermal delivery of drugs that produce elevated local concentrations. Skin microvascular function has also been proposed as a prognostic biomarker or for evaluating the effect of drugs. Comprehension of the physiological pathways, together with recent technological improvements in microcirculation imaging, has provided reliable and reproducible tools to study skin microcirculation.

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Impact of age and gender on microvascular function

Abstract: During adolescence, PORH is a function of age. At higher age, microvascular reactivity considerably depends on gender, whereas no sex differences are present at younger ages.

Cited by 17 publications

References 35 publications

Functional characterization of collaterals in the human gingiva by laser speckle contrast imaging

Functional characterization of collaterals in the human gingiva by laser speckle contrast imaging

The tissue viability imaging system—Suitable method for discovering minimal skin changes in occupational screenings? Results of a cross‐sectional field study

Current Methods to Assess Human Cutaneous Blood Flow: An Updated Focus on Laser‐Based‐Techniques

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