Impact of aflatoxin B1 on hypothalamic neuropeptides regulating feeding behavior

Trebak, Fatima; Alaoui, Abdelilah Lamrani; Dionne‐Laporte, Alexandre; Ouezzani, Seloua El; Anouar, Youssef; Chartrel, Nicolas; Magoul, Rabia

doi:10.1016/j.neuro.2015.06.008

Cited by 44 publications

(26 citation statements)

References 54 publications

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“…It increases oxidative stress in rat kidney thereby leading to changes in renal function and ultimately causing kidney damage. It has also been shown to increase oxidative stress and apoptosis in the spleen of broilers ( 19 – 24 ). The hepatotoxicity of AFB1 has been well documented, and we have previously reported the effect of the co-exposure on the liver ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet

Rotimi

Oluwafemi

et al. 2018

ToxicolRes

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Early life exposure to aflatoxin B1 (AFB1) and low protein diet through complementary foods during weaning is common in parts of Africa and Asia. This study evaluated the effect of co-exposure to AFB1 and low protein diet on the extrahepatic tissues of rats. Twenty-four three-week old weanling male albino rats were used for this study and were randomly assigned into four groups: group 1 served as control and was fed normal protein diet (20% protein), group 2 was fed low protein diet (5% protein), group 3 was fed normal protein diet + 40 ppb AFB1 while group 4 received low protein diet + 40 ppb AFB1, all for eight weeks. Afterward, biomarkers of anemia (packed cell volume (PCV), hemoglobin) and kidney function (urea, uric acid, and creatinine) were determined in the blood while biomarkers of oxidative stress were determined in the tissues spectrophotometrically. Co-exposure to AFB1 and low protein diet significantly (p < 0.05) decreased body weight gain and PCV, increased biomarkers of kidney functions and induced oxidative stress in the tissues studied. There was significant (p < 0.05) reduction in glutathione concentration while TBARS was significantly increased in the tissues. Co-exposure to AFB1 and low protein diet had additive effects on decreasing the weight gain and potentiation effect of kidney dysfunction in the rats. The co-exposure also decreased antioxidant enzymes and increased oxidant status in the tissues. Our results demonstrate that this co-exposure has deleterious health effects on extrahepatic tissues and should be a public health concern especially in developing countries where AFB1 contamination is common.

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Section: Introductionmentioning

confidence: 99%

Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet

Rotimi

Oluwafemi

et al. 2018

ToxicolRes

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“…As a consequence, an increase in the formation of AFB1-DNA adducts as well as a decrease in the expression of the VDR receptor, could be foreseen. If further confirmed, this aflatoxin mode of action may exert an important role in increasing the risk of calcium deficiency and malnutritionrelated diseases in Africa [58].…”

Section: Aflatoxins and Trichothecenes: Endocrine And Neuroendocrine mentioning

confidence: 83%

“…Very recently, the possible interaction between AFB1 and vitamin D receptors has been described [58]. According to the authors, the expression of vitamin D receptor (VDR) in osteosarcoma cell line SAOS-2 seemed to be significantly down-regulated by exposure to AFB1.…”

Section: Aflatoxins and Trichothecenes: Endocrine And Neuroendocrine mentioning

confidence: 99%

Mycotoxins and Nuclear Receptors: A Still Underexplored Issue

Dall’Asta¹

2016

Nuclear Receptor Research

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Abstract.Mycotoxins are fungal secondary metabolites that can be found in food commodities worldwide. They exert a wide range of adverse effects towards humans and animals. Although toxicological studies have addressed these food contaminants over decades, their mode of actions as well as their synergistic effects are still to be deeply clarified. Among the toxicological targets, nuclear receptors have been identified by several studies. Besides the estrogenic effect, a wider range of endocrine and neuroendocrine disrupting effects have been reported so far. This review is aimed at addressing the recent advances in toxicology, and at highlighting possible gaps of knowledge.

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“…Hussain et al reported experimental birds intoxicated with 400-800 μg kg −1 AFB 1 showed depression, ruffled feathers, watery feces, decrease in water and feed consumption, and nervous signs as torticollis and mortality [71]. Trebak et al reported listlessness, anorexia [72]; other symptoms include poor feed utilization, stunted growth, decrease weight gain [73,74]; reduced egg weight and production. High levels of aflatoxins in broilers and turkeys cause hepatomegaly, fatty degeneration, fatty liver, bile conduct proliferation, periportal fibrosis, renal petechiations, tubular nephrosis, interstitial nephritis, and splenic atrophy [67,75].…”

Section: Effects On Poultrymentioning

confidence: 99%

“…Some researchers have found a significant decrease in feed consumption, egg production, egg weight, shell weight, shell thickness, and feed conversion ratio value in laying hens fed with 15 μg kg −1 of AFB 1 [78,79]. Aflatoxins disrupt the hypothalamic regulation of neuropeptides involved in feeding behavior and contribute to the lower body weight and decreased weight gain [72]. Aflatoxins in the feed of laying hens may cause a relevant lesion in liver, kidneys, heart, and ovaries.…”

Section: Effects On Poultrymentioning

confidence: 99%

A Focus on Aflatoxins in Feedstuffs: Levels of Contamination, Prevalence, Control Strategies, and Impacts on Animal Health

Alvarado¹,

Zamora-Sanabria²,

FabioGranados-Chinchilla³

2017

Aflatoxin-Control, Analysis, Detection and Health Risks

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Aflatoxins are mold-synthetized secondary metabolites that are ubiquitously present in agricultural commodities, such as cereals which in turn are substantial part of feed formulation. These toxins are capable of causing disease, exert severe toxic effects, and even death in humans and other animals. Aflatoxins are the only mycotoxins with the regulatory framework, hence we present the legal threshold uphold till now by international and regional control organizations. Additionally, herein we discuss worldwide prevalence of aflatoxins in feeds to demonstrate a global issue and major risks involved in toxin contamination. Furthermore, we present recent data regarding negative effects usually presented by food-producing and companionship animals when ingested. Also, we discuss briefly practical approaches to mitigate aflatoxin burden during feed processing focusing in Good Manufacturing Practice (GMP) and hazard analysis critical control point (HACCP) and we include novel approaches reported in literature to decontaminate feedcontaining aflatoxins. Finally, we cite the literature so far published describing the effects of changing climate on aflatoxin production and contamination.

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Impact of aflatoxin B1 on hypothalamic neuropeptides regulating feeding behavior

Cited by 44 publications

References 54 publications

Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet

Oxidative Stress in Extrahepatic Tissues of Rats Co-Exposed to Aflatoxin B1 and Low Protein Diet

Mycotoxins and Nuclear Receptors: A Still Underexplored Issue

A Focus on Aflatoxins in Feedstuffs: Levels of Contamination, Prevalence, Control Strategies, and Impacts on Animal Health

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