Impact of aerobic exercise and fatty acid supplementation on global and gene-specific DNA methylation

David, Hunter; James, Lynsey S.; Hussey, Bethan; Wadley, Alexander J.; Lindley, Martin R.; Mastana, Sarabjit S.

doi:10.1080/15592294.2019.1582276

Cited by 59 publications

(54 citation statements)

References 88 publications

(126 reference statements)

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“…Few studies on EVOO and epigenetic modulation have been conducted. Recent papers have reported that EVOO supplementation can modulate DNA methylation in vivo [42], and downregulate HDAC2 and HDAC3; this second effect in particular might be exerted, as newly hypothesized, by a specific compound: oleuropein [43]. On the other hand, thymoquinone is probably the main compound responsible for modulation of gene expression observed in cells treated with NG oil.…”

Section: Discussionmentioning

confidence: 84%

Extra Virgin Olive Oil and Nigella sativa Oil Produced in Central Italy: A Comparison of the Nutrigenomic Effects of Two Mediterranean Oils in a Low-Grade Inflammation Model

et al. 2019

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Extra virgin olive (EVO) oil and Nigella sativa (NG) oil are two well-known Mediterranean foods whose consumption has been associated with beneficial effects on human health. This study investigates the nutrigenomic properties of two high quality EVO and NG oils in an in vitro model of low-grade inflammation of human macrophages (THP-1 cells). The aim was to assess whether these healthy foods could modulate inflammation through antioxidant and epigenetic mechanisms. When THP-1 cells were co-exposed to both lipopolysaccharides (LPS)-induced inflammation and oils, both EVO and NG oils displayed anti-inflammatory activity. Both oils were able to restore normal expression levels of DNMT3A and HDAC1 (but not DNMT3B), which were altered under inflammatory conditions. Moreover, EVO oil was able to prevent the increase in TET2 expression and reduce global DNA methylation that were measured in inflamed cells. Due to its antioxidant properties, EVO oil was particularly efficient in restoring normal levels of membrane fluidity, which, on the contrary, were reduced in the presence of inflammation. In conclusion, these data support the hypothesis that these Mediterranean oils could play a major role in the modulation of low-grade inflammation and metabolic syndrome prevention. However, NS oil seems to be more efficient in the control of proinflammatory cytokines, whereas EVO oil better helps to counteract redox imbalance. Further studies that elucidate the nutrigenomic properties of local produce might help to promote regional the production and consumption of high-quality food, which could also help the population to maintain and promote health.

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Section: Discussionmentioning

confidence: 84%

Extra Virgin Olive Oil and Nigella sativa Oil Produced in Central Italy: A Comparison of the Nutrigenomic Effects of Two Mediterranean Oils in a Low-Grade Inflammation Model

et al. 2019

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“…In contrast, EVOO‐containing diets decreased Dnmt3b expression in mammary tumours. Conversely, supplementation with EVOO has been shown to decrease DNMT1 expression in human peripheral blood leukocytes (Hunter et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…These methylation changes were predominately in gene bodies and corresponded to changes in gene expression. A clinical intervention trial also demonstrated that supplementation for 8 days with n ‐3 PUFA (5.7 g·day −1 ) and EVOO (6 g·days −1 ) caused differential effects on the methylation of the gene encoding interleukin‐6 ( IL‐6 ) and expression of DNMT1 in circulating leukocytes (Hunter et al, ). Specifically, methylation of IL‐6 was increased following n ‐3 PUFA supplementation, whereas EVOO caused decreased methylation.…”

Section: Dietary Fat Obesity and Targeting Of Dna Methylation In Bcmentioning

confidence: 99%

Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation

Donovan

Wren

Cenker

et al. 2020

British J Pharmacology

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Breast cancer (BC) is the most common cancer and second leading cause of cancer mortality in women worldwide. Validated biomarkers enhance efforts for early detection and treatment, which reduce the risk of mortality. Epigenetic signatures have been suggested as good biomarkers for early detection, prognosis and targeted therapy of BC. Here, we highlight studies documenting the modifying effects of dietary fatty acids and obesity on BC biomarkers associated with DNA methylation. We focus our analysis on changes elicited in writers of DNA methylation (i.e., DNA methyltransferases), global DNA methylation and gene‐specific DNA methylation. To provide context, we precede this discussion with a review of the available evidence for an association between BC incidence and both dietary fat consumption and obesity. We also include a review of well‐vetted BC biomarkers related to cytosine‐guanine dinucleotides methylation and how they influence BC risk, prognosis, tumour characteristics and response to treatment. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…Besides, several ‘anti-aging’ nutraceutical compounds have been recently proposed to counteract oxidative stress and senescence [ 40 ]. For example, both omega 3 polyunsaturated fatty acids (ω-3 PUFA) and extra virgin olive oil (EVOO) have been reported to exert numerous metabolic and cardiovascular benefits in the elderly due to their high content in antioxidant compounds [ 199 , 200 , 201 , 202 ]. In old rats, the treatment prevented aging-induced endothelial dysfunction, oxidative stress, inflammation, and vascular insulin resistance through activation of the PI3K/Akt pathway and decreasing the response to the vasoconstrictor angiotensin II [ 202 ].…”

Section: New Therapeutic Approaches Targeted Endothelial Dysfunctimentioning

confidence: 99%

Oxidative Stress and New Pathogenetic Mechanisms in Endothelial Dysfunction: Potential Diagnostic Biomarkers and Therapeutic Targets

Scioli

Storti

D’Amico

et al. 2020

JCM

107

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Cardiovascular diseases (CVD), including heart and pathological circulatory conditions, are the world’s leading cause of mortality and morbidity. Endothelial dysfunction involved in CVD pathogenesis is a trigger, or consequence, of oxidative stress and inflammation. Endothelial dysfunction is defined as a diminished production/availability of nitric oxide, with or without an imbalance between endothelium-derived contracting, and relaxing factors associated with a pro-inflammatory and prothrombotic status. Endothelial dysfunction-induced phenotypic changes include up-regulated expression of adhesion molecules and increased chemokine secretion, leukocyte adherence, cell permeability, low-density lipoprotein oxidation, platelet activation, and vascular smooth muscle cell proliferation and migration. Inflammation-induced oxidative stress results in an increased accumulation of reactive oxygen species (ROS), mainly derived from mitochondria. Excessive ROS production causes oxidation of macromolecules inducing cell apoptosis mediated by cytochrome-c release. Oxidation of mitochondrial cardiolipin loosens cytochrome-c binding, thus, favoring its cytosolic release and activation of the apoptotic cascade. Oxidative stress increases vascular permeability, promotes leukocyte adhesion, and induces alterations in endothelial signal transduction and redox-regulated transcription factors. Identification of new endothelial dysfunction-related oxidative stress markers represents a research goal for better prevention and therapy of CVD. New-generation therapeutic approaches based on carriers, gene therapy, cardiolipin stabilizer, and enzyme inhibitors have proved useful in clinical practice to counteract endothelial dysfunction. Experimental studies are in continuous development to discover new personalized treatments. Gene regulatory mechanisms, implicated in endothelial dysfunction, represent potential new targets for developing drugs able to prevent and counteract CVD-related endothelial dysfunction. Nevertheless, many challenges remain to overcome before these technologies and personalized therapeutic strategies can be used in CVD management.

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Impact of aerobic exercise and fatty acid supplementation on global and gene-specific DNA methylation

Cited by 59 publications

References 88 publications

Extra Virgin Olive Oil and Nigella sativa Oil Produced in Central Italy: A Comparison of the Nutrigenomic Effects of Two Mediterranean Oils in a Low-Grade Inflammation Model

Extra Virgin Olive Oil and Nigella sativa Oil Produced in Central Italy: A Comparison of the Nutrigenomic Effects of Two Mediterranean Oils in a Low-Grade Inflammation Model

Dietary fat and obesity as modulators of breast cancer risk: Focus on DNA methylation

Oxidative Stress and New Pathogenetic Mechanisms in Endothelial Dysfunction: Potential Diagnostic Biomarkers and Therapeutic Targets

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