Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects

Matsuda, Masafumi; Kawasaki, Fumiko; Yamada, Kazunori; Kanda, Yukiko; Saito, Mieko; Eto, Masashi; Matsuki, Michihiro; Kaku, Kohei

doi:10.1111/j.1464-5491.2004.01261.x

Cited by 66 publications

(53 citation statements)

References 32 publications

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“…Similar results have been reported in the literature in type I DM [5][6][7][8][9], whereas type II DM has been associated with low serum adiponectin levels [10][11][12][13]. The increase in serum adiponectin levels in type I DM, in contrast to type II DM, may be due to a lack of insulin; glucose and insulin may play an important role in the increased serum adiponectin levels observed in type I DM [5,14] However, Berg et al showed that serum adiponectin levels do not change in mice after the onset of diabetes although the insulin levels decrease dramatically [15].…”

Section: Discussionsupporting

confidence: 79%

Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy

Tasci

Özbek

Önenli-Mungan

et al. 2011

EAJM

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Objective: The aim of this study was to elucidate the role of adiponectin, leptin, TNF-α and IL-6 on the early detection of the microvascular complications of type I diabetes. Materials and Methods:A total of 88 children were included in the study. There were 60 type I diabetic patients and 28 healthy control children. Results:The gender, age, weight, height, BMI and puberty status characteristics were similar in the patient and control groups (p>0.05). The serum leptin, TNF-α and IL-6 levels were similar between the patient and control groups (p>0.05) and the only diff erence was in the serum adiponectin level which was higher in the patient group (p:0.042). We also found no association between the adiponectin, leptin, TNF-α and IL-6 levels and diabetes duration (p>0.05). Leptin was high in the pubertal period (p:0.016), while adiponectin TNF-α and IL-6 levels were similar in the prepubertal and pubertal periods (p>0.05). The serum leptin level was high in microalbuminuria patients (p<0.041). The serum adiponectin, TNF-α, and IL-6 levels were not diff erent in patients with and without microalbuminuria (p>0.05). The serum adiponectin level was lower in diabetic retinopathy patients (p:0.003), while the serum leptin level was higher (p:0.003). The TNF-α and IL-6 levels were similar in patients with and without retinopathy (p>0.05). Conclusion:We found increased serum adinopectin levels in children and adolescents with type I diabetes mellitus and low levels in diabetic retinopathy patients. Patients with low serum adiponectin levels and high leptin levels should be more closely monitored for chronic complication development and better metabolic control should be aimed for.

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Section: Discussionsupporting

confidence: 79%

Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy

Tasci

Özbek

Önenli-Mungan

et al. 2011

EAJM

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“…A reduction in insulin sensitivity of hepatocytes as well as disturbance of glucose metabolism may also be promoted. Recent advances in the biology of adipose tissue have demonstrated that adipose tissue is not an energy storage organ but secretes a variety of molecules which affect metabolism of the whole body (26,27). This article found an effect of AFI on IMT after adjusting for other atherosclerotic risks.…”

Section: Discussionmentioning

confidence: 57%

Association between Abdominal Wall Fat Index on Ultrasonography and Carotid Atherosclerosis in Non-obese Men

Kawamoto

Oka

Tomita

et al. 2005

JAT

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We tried to investigate whether accumulation of visceral fat, assessed by a simple but widely used ultrasonographic method, was associated with common carotid atherosclerosis in non-obese men ranging from 16 to 79 years old. The subjects were consecutive 297 male in-patients whose body mass index ranged from 18.5 kg/m 2 to 25 kg/m 2 . An ultrasonographic evaluation using a 7.5 MHz linear type B-mode probe was performed by a specialist to determine the intima-media thickness (IMT) of the common carotid artery and the maximal thickness of peritoneal fat (Pmax) at the anterior surface of the liver and the minimal thickness of subcutaneous fat (Smin) of the abdomen. The Pmax/Smin ratio, which was termed the abdominal wall fat index (AFI), was then calculated. The mean age ± ± ± ± ± standard deviation in this series was 65 ± ± ± ± ± 13 (range, 15-79) years. Multiple regression analysis using IMT as an objective variable, adjusted by various risk factors as explanatory variables, showed that AFI [ β β β β β, 0.0538; 95% confidence interval (CI), 0.0116-0.0960 ] was a significant independent contributing factor along with known risk factors such as age, smoking status, systolic blood pressure, HDL-cholesterol and LDL-cholesterol. We found that AFI was useful in evaluating disorders of metabolism and atherosclerosis in non-obese men. J Atheroscler Thromb, 2005; 12: 85-91.

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“…However, the correlation between IR and plasma resistin in adult humans remains controversial, supported by some studies [12] and not by some others [13,14], therefore, weakening the relation between resistin and MetS. Some authors indicated that increased plasma resistin levels were associated with increased obesity, visceral fat [1,15,16] insulin resistance, and type 2 diabetes [12], while other groups failed to observe such correlations [17,18]. Furthermore, the contribution of resistin to the MetS is still under investigation [19,20].…”

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confidence: 99%

Association of Resistin with Insulin Resistance and Factors of Metabolic Syndrome in North Indians

Singh¹,

Tiwari

Gupta

et al. 2014

Ind J Clin Biochem

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Metabolic syndrome (MetS) is a cluster of interrelated common clinical disorders. The role of resistin in insulin sensitivity and MetS is controversial till date. So, the aim of the present study was to investigate the relationship of plasma resistin levels with markers of the MetS in Indian subjects. In a case control study, total 528 subjects were selected for the study. 265 (194 male and 71 female) were cases (with MetS) and 263 (164 male and 99 female) were controls (without MetS). Required anthropometric measurements and calculations were carried out accordingly. All the Biochemical estimations were carried out according to standard protocol. Resistin level was measured by the standard protocol (By ELISA i.e. enzyme linked immunosorbent assay) as illustrated in the kit. Insulin level was also measured by the standard protocol as illustrated in the kit and insulin resistance was calculated by the standard procedures. Plasma resistin levels were significantly higher in cases compared with controls (male = 13.05 ± 4.31 vs. 7.04 ± 2.09 ng/ml; p B 0.001 and female = 13.53 ± 4.14 vs. 7.42 ± 2.30 ng/ml; p B 0.001). Plasma resistin levels were well correlated with waist circumference, glucose, triglycerides, waist/hip ratio, systolic and diastolic blood pressure, high density lipoprotein, total cholesterol, serum low density lipoprotein, serum very low density lipoprotein, insulin and insulin resistance. Plasma resistin levels were elevated in presence of the MetS and were associated with increased metabolic risk factors.

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Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects

Abstract: The present observations suggest that visceral and subcutaneous fat has an impact on microangiopathy as well as macroangiopathy, possibly through different adipocytokines.

Cited by 66 publications

References 32 publications

Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy

Low Serum Adiponectin Levels in Children and Adolescents with Diabetic Retinopathy

Association between Abdominal Wall Fat Index on Ultrasonography and Carotid Atherosclerosis in Non-obese Men

Association of Resistin with Insulin Resistance and Factors of Metabolic Syndrome in North Indians

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