Impact of acute stress on itch sensation and scratching behaviour in patients with atopic dermatitis and healthy controls

Mochizuki, Hideki; Lavery, Michael Joseph; Nattkemper, Leigh; Albornoz, Christian A.; Rodríguez, Rodrigo Valdés; Stull, Carolyn; Weaver, Leslie; Hamsher, J. Herbert; Sanders, Kristen M.; Chan, Yiong‐Huak; Yosipovitch, Gil

doi:10.1111/bjd.16921

Cited by 41 publications

(43 citation statements)

References 44 publications

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“…Skin prick test (SPT) was used to measure IgE‐mediated allergy disorders in the infants with rhino conjunctivitis, asthma, urticaria, anaphylaxis, atopic eczema, and milk allergy. Allergic severity (score) was evaluated by using eczema area and severity index score (Mochizuki et al., 2018). Histamine was used as the positive control and the saline was used the negative control.…”

Section: Methodsmentioning

confidence: 99%

Bifidobacterium bifidumTMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double‐blind control trial

2020

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We aimed to explore the effects of Bifidobacterium bifidum TMC3115 intervention on cow's milk protein allergy (CMPA) and gut microbiota in infants. A total 256 CMPA infants were randomly and evenly assigned into an intervention group (B. bifidum) and a control group (placebo). Allergic scores, anti-inflammatory responses, and secondary outcomes were measured. Fecal specimens were collected, and the gut microbiota were analyzed by using 16S rDNA sequencing. After 6-month B. bifidum intervention, B. bifidum TMC3115 consumption reduced allergic scores, and improved anti-inflammatory responses and secondary outcomes in CMPA infants. LEfSe analysis showed Bifidobacterium, Lactobacillus, Turicibacter, Sutterella, and Parabacteroides were the most predominant phylum in the intervention group, whereas the Firmicutes (Anaerovibrio, Christensenellaceae, Oscillibacter, Bilophila, Dorea, and Roseburia) were most dominant phyla in the control group. Serum IgE or IgG2 had a strong relationship with α-diversity scores of gut microbiota. Practical applications There is a high level of prevalence of milk allergy in infants, which is difficult to be treated. Bifidobacterium bifidum TMC3115 supplement reduced allergic scores, improved anti-inflammatory responses, and reduced serum level of IgE and increased the level of IgG2 in the infants. On the contrary, B. bifidum supplement increased the genus proportion of probiotics and reduced the proportion of pathogens. The improvement of gut microbiota will be beneficial in the prevention of milk allergy. B. bifidum TMC3115 reduces milk allergy in the infants by regulating gut microbiota, and should be developed a potential way in the prevention of infant milk allergy.

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Section: Methodsmentioning

confidence: 99%

Bifidobacterium bifidumTMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double‐blind control trial

2020

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“…The associations between stress and itch in patients with AD constitute a problem of particular complexity and importance and involve the components of the so-called neuro-endocrino-immunocutaneous system (NEICS) and the hypothalamo-pituitary-adrenal (HPA axis). The relevant aspects of this issue are covered in detail elsewhere (33)(34)(35)(36)(37)(38), although there is evidence that acute or chronic stress have different impacts on the HPA axis (39).…”

Section: Itch and Stressmentioning

confidence: 99%

Itch and Psyche: Bilateral Associations

Reszke¹,

Szepietowski²

2020

Acta Derm Venerol

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The relationship between itch and psyche is complex and bilateral. Increasing interest in itch and its associations with psyche is indicated by the abundance of experimental and clinical articles published in this field. This review covers the pathogenesis of itch, associations with stress, the contagiousness of itch, psychological and psychiatric aspects related to itch, and the burden of itch with respect to impairment of health-related quality of life and stigmatization. Beginning from embryological development, skin and psyche are closely related to physiological state regardless of age. Altering the homeostasis of one of these components impacts on the other, thereby substantiating that the relationship between itch and psyche is bilateral. Itch has a complex pathogenesis, which involves the peripheral and central nervous systems, as well as various inflammatory mediators. This paper reviews key aspects of itch pathogenesis, relevant associations with stress, the contagiousness of itch, psychological and psychiatric considerations related to itch, and the burden of itch with respect to impairment of health-related quality of life (HRQoL) and stigmatization. Despite the fact that itch-psyche associations still pose many questions, current knowledge supports the role of a holistic, interdisciplinary approach to these patients in order to improve their well-being.

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“…Most triggering factors are non‐allergic, like sweating, mechanical irritation, such as long nails, clothing, exposure to water, soaps, or chemicals and climactic factors (low humidity and cold temperature) 15,16 . Even stress can worsen AD and its symptoms 17 . Food, contact and airborne allergens can also act as triggering factors 18 …”

Section: Epidemiology Exacerbating Factors and Itch And Pain In Admentioning

confidence: 99%

A position paper on the management of itch and pain in atopic dermatitis from the International Society of Atopic Dermatitis (ISAD)/Oriented Patient‐Education Network in Dermatology (OPENED) task force

Miséry

Fortina

Hachem

et al. 2020

Acad Dermatol Venereol

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Atopic dermatitis (AD) is a disease that can have a high impact on quality of life, especially due to itch and skin pain. This paper utilizes expertise from members of the International Society of Atopic Dermatitis (ISAD)/Oriented Patient‐Education Network in Dermatology (OPENED) task force to review the epidemiology, pathophysiology and exacerbating factors of itch and pain in atopic dermatitis. General principles of treatment are provided, as well as a more detailed evaluation of topical and systemic therapies. Educational and psychological approaches to itch and pain in atopic dermatitis are proposed, along with expert recommendations for the management of itch and pain in atopic dermatitis.

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Impact of acute stress on itch sensation and scratching behaviour in patients with atopic dermatitis and healthy controls

Cited by 41 publications

References 44 publications

Bifidobacterium bifidumTMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double‐blind control trial

Bifidobacterium bifidumTMC3115 ameliorates milk protein allergy in by affecting gut microbiota: A randomized double‐blind control trial

Itch and Psyche: Bilateral Associations

A position paper on the management of itch and pain in atopic dermatitis from the International Society of Atopic Dermatitis (ISAD)/Oriented Patient‐Education Network in Dermatology (OPENED) task force

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