Impact of acute kidney injury after extended liver resections

Reese, Tim; Kröger, Fabian; Makridis, Georgios; Drexler, Richard; Jusufi, Maximilian Stanley; Schneider, Martin; Brüning, R.; Rittberg, York von; Wagner, Kim C.; Oldhafer, Karl J.

doi:10.1016/j.hpb.2020.10.015

Cited by 14 publications

(10 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…44 In contrast, kinetic growth per week between 2 and 7 months postoperatively was less among undergoing extended liver resection and the incidence of chronic kidney disease was significantly higher in patients with AKI. 46 In the AKI group, the proportion of extended right hepatectomies was the highest (53%), followed by ALPPS (43%). Besides age and chronic kidney disease, ALPPS was an independent risk factor for postoperative AKI.…”

Section: Clinical and Experimental Studies Effectively Reported Thatmentioning

confidence: 90%

“…ALPPS is a major independent risk factor for the development of AKI and a sufficient future liver remnant could avoid postoperative AKI. Reese et al included 146 patients undergoing extended liver resection and the incidence of chronic kidney disease was significantly higher in patients with AKI 46 . In the AKI group, the proportion of extended right hepatectomies was the highest (53%), followed by ALPPS (43%).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Liver growth prediction in ALPPS – A multicenter analysis from the international ALPPS registry

López-López

Linecker

Cruz

et al. 2022

Liver International

Self Cite

View full text Add to dashboard Cite

Background While ALPPS triggers a fast liver hypertrophy, it is still unclear which factors matter most to achieve accelerated hypertrophy within a short period of time. The aim of the study was to identify patient‐intrinsic factors related to the growth of the future liver remnant (FLR). Methods This cohort study is composed of data derived from the International ALPPS Registry from November 2011 and October 2018. We analyse the influence of demographic, tumour type and perioperative data on the growth of the FLR. The volume of the FLR was calculated in millilitre and percentage using computed‐tomography (CT) scans before and after stage 1, both according to Vauthey formula. Results A total of 734 patients were included from 99 centres. The median sFLR at stage 1 and stage 2 was 0.23 (IQR, 0.18–0.28) and 0.39 (IQR: 0.31–0.46), respectively. The variables associated with a lower increase from sFLR1 to sFLR2 were age˃68 years (p = .02), height ˃1.76 m (p ˂ .01), weight ˃83 kg (p ˂ .01), BMI˃28 (p ˂ .01), male gender (p ˂ .01), antihypertensive therapy (p ˂ .01), operation time ˃370 minutes (p ˂ .01) and hospital stay˃14 days (p ˂ .01). The time required to reach sufficient volume for stage 2, male gender accounts 40.3% in group ˂7 days, compared with 50% of female, and female present 15.3% in group ˃14 days compared with 20.6% of male. Conclusions Height, weight, FLR size and gender could be the variables that most constantly influence both daily growths, the interstage increase and the standardized FLR before the second stage.

show abstract

Section: Clinical and Experimental Studies Effectively Reported Thatmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Liver growth prediction in ALPPS – A multicenter analysis from the international ALPPS registry

López-López

Linecker

Cruz

et al. 2022

Liver International

Self Cite

View full text Add to dashboard Cite

show abstract

“…Portal hypertension may cause severe liver damage and reduce parenchymal restoration through over-release of in ammatory cytokines [5,6]. A recent study indicated that the acute systemic in ammation is associated with extended hepatectomy, and a su cient future liver remnant could avoid postoperative injury [7]. The efforts to explore the mechanism of the systemic in ammation and attenuate the liver injury of the remnant liver are still limited [1,2].…”

Section: Introductionmentioning

confidence: 99%

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Shi

Bai

Yan

et al. 2022

Preprint

View full text Add to dashboard Cite

Background The regulation mechanism of post-operative hepatic failure and small-for-size syndrome remains unclear. Thus, we aimed to analyze the molecular profiles following extended hepatectomy and identify the therapeutic target. Methods Major hepatectomy and extended hepatectomy were performed in the rat model, and the remnant livers were obtained dynamically for the high-throughput transcriptome analysis to identify the differentially expressed genes (DEGs). The general framework for weighted gene co-expression network analysis (WGCNA) was employed to explore the expression patterns of DEGs. The expression and function of the selected DEG from the WGCNA was further verified following hepatectomy in the human and rat. Results DEGs after major hepatectomy and extended hepatectomy were detected by transcriptomics. WGCNA identified 10 distinct gene co-expression modules according to the correlation between module eigengene and different postoperative time-points. The magenta module (gene count: 289) and the lightcyan module (gene count: 484) were found positively correlated with major hepatectomy instead of extended hepatectomy. In the lightcyan module, peroxisome proliferator-activated receptor-α (PPARα) was selected and found the down-regulation in the remnant liver following extended (marginal) hepatectomy in rats and humans. Besides, administration of PPARα agonist attenuated hepatic inflammation injury while PPARα antagonist increased liver inflammation injury after extended hepatectomy in rats, marked by the significantly changed aminotransferases, tumor necrosis factor-α and interleukin-6 levels in the plasm, and histological Suzuki criteria. Conclusion DEGs and their molecular profiles after extended hepatectomy were identified, and PPARα could be a potential therapy target for small-for-size syndrome.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Portal hypertension may cause severe liver damage and reduce parenchymal restoration through over-release of inflammatory cytokines (Athanasiou et al 2017; Govil 2020). A recent study indicated that the acute kidney injury is associated with extended hepatectomy, and a sufficient future liver remnant could avoid postoperative injury (Reese et al 2021). The efforts to explore the mechanism of the systemic inflammation and attenuate the liver injury of the remnant liver are still limited (Riddiough et al 2020; Rajakumar et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Shi

Bai

Yan

et al. 2021

Preprint

View full text Add to dashboard Cite

The regulation mechanism of small-for-size syndrome remains unclear. Thus, we aimed to analyze the molecular profiles following extended hepatectomy and identify the therapeutic target. Major hepatectomy and extended hepatectomy were performed in the rat model, and the remnant livers were obtained dynamically for the high-throughput transcriptome analysis to identify the differentially expressed genes (DEGs). The general framework for weighted gene co-expression network analysis (WGCNA) was employed to explore the expression patterns of DEGs. As result, WGCNA identified 10 distinct gene co-expression modules according to the correlation between module eigengene and different postoperative time-points. The magenta module (gene count: 289) and the lightcyan module (gene count: 484) were found positively correlated with major hepatectomy instead of extended hepatectomy. In the lightcyan module, peroxisome proliferator-activated receptor-α (PPARα) was selected and found the down-regulation in the remnant liver following extended (marginal) hepatectomy in rats and humans. Besides, administration of PPARα agonist attenuated hepatic inflammation injury while PPARα antagonist increased liver inflammation injury after extended hepatectomy in rats, marked by the significantly changed aminotransferases, tumor necrosis factor-α and interleukin-6 levels in the plasm, and histological Suzuki criteria. Consequently, DEGs and their molecular profiles after extended hepatectomy were identified, and PPARα might be a potential therapy target for small-for-size syndrome.

show abstract

Impact of acute kidney injury after extended liver resections

Cited by 14 publications

References 25 publications

Liver growth prediction in ALPPS – A multicenter analysis from the international ALPPS registry

Liver growth prediction in ALPPS – A multicenter analysis from the international ALPPS registry

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Protective effect of peroxisome proliferator-activated receptor-α in regulating the early inflammation response to extended hepatectomy from a comparative transcriptomic analysis

Contact Info

Product

Resources

About