Impact of acute kidney injury on mortality and medical costs in patients with meticillin-resistant Staphylococcus aureus bacteraemia: a retrospective, multicentre observational study

Joo, Eun-Jeong; Peck, Kyong Ran; Ha, Young Eun; Kim, Young-Sung; Song, Young Goo; Lee, S.-S.; Ryu, Seong Yeol; Moon, Chisook; Lee, C.-S.; Park, K.-H.

doi:10.1016/j.jhin.2012.12.008

Cited by 10 publications

(12 citation statements)

References 28 publications

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“…Factors that were previously shown to be predictive of inhospital mortality correlated with the variables identified in our study, including age, 25 sepsis, 25,26 admission to the ICU, 27 hepatic failure, 25 COPD and metastatic cancer. 28,29 The large sample size allowed us to investigate the association between specific patient characteristics and outcomes, rather than aggregating comorbidities using scales such as the Charlson Comorbidity Index. An additional novelty of this study is the identification of risk factors associated with 90-day postdischarge mortality, given that an increasing number of patients with S. aureus bacteremia are surviving beyond the length of their hospital stay.…”

Section: Discussionmentioning

confidence: 99%

Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study

et al. 2014

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“…An understanding of the health care resource use associated with AKI is needed by decision makers to frame the investment and cost-effectiveness of potential strategies. Existing studies have limitations, including incomplete assessment of baseline kidney function before hospitalization, a lack of stratification by AKI severity and need for dialysis, a lack of consideration of kidney recovery, short-term follow-up limited to the index hospitalization, and focus on specific settings [e.g., intensive care unit (17,18)] or disease states [e.g., surgery (19), cardiovascular surgery (20)(21)(22), vascular surgery (23), malignancy (24,25), and infection (26,27)]; we did not identify studies that reflect a population-based perspective.…”

Section: Introductionmentioning

confidence: 99%

Health Care Costs Associated with AKI

Collister

Pannu

Feng

et al. 2017

CJASN

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“…1–5 Previous studies reporting the incidence and sequelae of AKI in the young focused on high-risk patient populations. Cohorts have been limited to those with nephrotoxic medications, 3,6–8 cardiac surgery/bypass, 9,10 sepsis, 11,12 or admission to an intensive care unit. 3,413–15 Due to patient selection, these may not accurately convey overall AKI incidence.…”

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confidence: 99%

Acute Kidney Injury Incidence in Noncritically Ill Hospitalized Children, Adolescents, and Young Adults: A Retrospective Observational Study

McGregor

Jones

Wang

et al. 2016

American Journal of Kidney Diseases

107

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Background Acute kidney injury (AKI) has been characterized in young high-risk inpatients, in whom AKI is frequent and associated with increased mortality, morbidity, and length of stay. The incidence of AKI among patients not requiring intensive care is unknown. Study Design Retrospective cohort study Setting & Participants 13,914 noncritical admissions during 2011–2012 at our tertiary referral pediatric hospital were evaluated. Patients <28 days or >21 years of age, or with chronic kidney disease (CKD), were excluded. Admissions with ≥2 serum creatinine measurements were evaluated. Factors Demographic features, laboratory measurements, medication exposures, and length of stay. Outcome AKI defined by increased serum creatinine in accordance with KDIGO (Kidney Disease: Improving Global Outcomes) criteria. Based on time of admission, time interval requirements were met in 97% of cases, but KDIGO time window criteria were not strictly enforced to allow implementation using clinically-obtained data. Results Two or more creatinine measurements (one baseline before or during admission, and a second during admission) in 2,374 of 13,914 (17%) patients allowed for AKI evaluation. A serum creatinine difference of ≥0.3 mg/dL or ≥1.5 times baseline was seen in 722 of 2,374 (30%) patients. A minimum of 5% of all noncritical inpatients without CKD in pediatric wards have an episode of AKI during routine hospital admission. Limitations Urine output, glomerular filtration rate, and time interval criteria for AKI were not applied secondary to study design and available data. The evaluated cohort was restricted to patients with ≥2 clinically obtained serum creatinine measurements, and baseline creatinine may have been measured after the AKI episode. Conclusions AKI occurs in at least 5% of all non-critically ill hospitalized children, adolescents, and young adults without known CKD. Physicians should increase their awareness of AKI and improve surveillance strategies with serum creatinine measurements in this population so that exacerbating factors such as nephrotoxic medication exposures may be modified as indicated.

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Impact of acute kidney injury on mortality and medical costs in patients with meticillin-resistant Staphylococcus aureus bacteraemia: a retrospective, multicentre observational study

Cited by 10 publications

References 28 publications

Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study

Risk factors for mortality among patients with Staphylococcus aureus bacteremia: a single-centre retrospective cohort study

Health Care Costs Associated with AKI

Acute Kidney Injury Incidence in Noncritically Ill Hospitalized Children, Adolescents, and Young Adults: A Retrospective Observational Study

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