Impact of Acute Caffeine Ingestion on Endothelial Function in Subjects With and Without Coronary Artery Disease

Shechter, Michael; Shalmon, Guy; Scheinowitz, Mickey; Koren‐Morag, Nira; Feinberg, Micha S.; Harats, Dror; Sela, Ben Ami; Sharabi, Yehonatan; Chouraqui, Pierre

doi:10.1016/j.amjcard.2010.12.035

Cited by 67 publications

(54 citation statements)

References 29 publications

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“…The effect of coffee on blood pressure has been extensively studied, with most studies reporting an increase in systolic and diastolic blood pressure [13,14,17,18,19,20,21,22] and with one failing to report an increase [23]. In our study, there were essentially no changes in systolic or diastolic blood pressure.…”

Section: Discussionmentioning

confidence: 36%

A Rapid Method to Evaluate Cardiac Repolarization Changes: The Effect of Two Coffee Strengths on the QT Interval

Molnár

Somberg

2015

Cardiology

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Objectives: To assess the effect of coffee on ventricular repolarization as measured by an electrocardiogram. Methods: Fifty-four healthy volunteers (34 males and 20 females, age 23 ± 5 years) received 1 cup of coffee (caffeine content 120 mg) and 11 participants received 2 cups. Blood pressure and heart rate were measured prior to coffee and every hour thereafter for 5 h. A 12-lead digital Holter recorded continuously, and RR, QT, and QTc intervals were obtained every 30 min. Results: Following coffee, RR increased from 802 ± 102 to 873 ± 126 ms (p = 0.001), QT increased from 359 ± 26 to 367 ± 27 ms at 1.5 h (p = 0.047), and QTc decreased from 387 ± 21 to 381 ± 23 ms at 30 min (p = 0.001), with no changes noted at other time points. Caffeine users and caffeine-naive subjects did not differ in QTc effects (p = 0.971). Females had longer QTc at each time point than males (p = 0.037), but neither had QTc prolongation following coffee. The heart rate decreased from 73 ± 9 to 69 ± 11 bpm at 1 h (p = 0.018), and no significant changes in blood pressure were noted. The effects of 1 or 2 cups of coffee did not differ in terms of QTc (p = 0.663), heart rate (p = 0.161), diastolic (p = 0.250), or systolic blood pressure (p = 0.168). Conclusion: Neither 1 nor 2 cups of coffee increased ventricular repolarization.

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Section: Discussionmentioning

confidence: 36%

A Rapid Method to Evaluate Cardiac Repolarization Changes: The Effect of Two Coffee Strengths on the QT Interval

Molnár

Somberg

2015

Cardiology

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“…Some studies have shown that acute administration of coffee has a harmful effect on endothelial function in healthy subjects [24,25], while other studies have shown that coffee improves endothelial function [26,27]. In addition, the association between coffee drinking and risk of cardiovascular disease remains inconclusive [15,[17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…However, there have been conflicting results regarding the association between coffee drinking and risk of cardiovascular disease [19][20][21][22][23]. The effect of coffee on endothelial function is also controversial [24][25][26][27]. One possible reason for the different results of studies is that the contents of chlorogenic acids, which are the most abundant antioxidants in coffee, may vary depending on several factors [16].…”

Section: Introductionmentioning

confidence: 99%

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

et al. 2018

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Purpose The purpose of this study was to evaluate acute effects of coffee with a high content of chlorogenic acids and different hydroxyhydroquinone contents on postprandial endothelial dysfunction. Methods This was a single-blind, randomized, placebo-controlled, crossover-within-subject clinical trial. A total of 37 patients with borderline or stage 1 hypertension were randomized to two study groups. The participants consumed a test meal with a single intake of the test coffee. Subjects in the Study 1 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or coffee with a high content of chlorogenic acids and a high content of hydroxyhydroquinone with crossover. Subjects in the Study 2 group were randomized to single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone or placebo coffee with crossover. Endothelial function assessed by flow-mediated vasodilation and plasma concentration of 8-isoprostanes were measured at baseline and at 1 and 2 h after coffee intake. Results Compared with baseline values, single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone, but not coffee with a high content of chlorogenic acids and high content of hydroxyhydroquinone or placebo coffee, significantly improved postprandial flow-mediated vasodilation and decreased circulating 8-isoprostane levels. Conclusions These findings suggest that a single intake of coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone is effective for improving postprandial endothelial dysfunction.

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“…After three days of caffeine administration, BP increased, but average HR was found to be decreased. Furthermore, Shechter et al [35] assessed the effect of acute caffeine ingestion (200 mg) on endothelial function, nitro-glycerine-mediated dilation (NTG) and high sensitivity hsCRP, in 80 subjects with/without coronary artery disease (CAD) [35] after one hour of administration. The endothelial function was increased; also, hsCRP decreased both in with/without CAD patients.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast, two studies enrolled by our criteria, were double blind, as absolute requirement (according to JADAD scale), since caffeine was administrated in capsules as placebo did. Shechter et al [35], demonstrated that 200 mg of caffeine administered as a single dose improved brachial endothelial function in controls and patients with CAD. Duffy et al [36] also observed an improvement in the endothelial function with the same dose and kind of patients, both after two hours and four weeks.…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Carbohydrates, Active Lipids and Nitrogen Compounds

Pastor-Villaescusa

Rangel-Huerta²,

Aguilera³

et al. 2015

Ann Nutr Metab

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Background/Aims: The prevalence of cardiovascular diseases (CVD) is rising and it is the prime cause of death in all developed countries. Bioactive compounds (BACs) can play a role in CVD prevention and treatment. To examine the scientific evidence supporting BACs groups' efficacy in CVD prevention and treatment, we conducted a systematized review. Methods: All available information on Medline, LILACS and EMBASE; all randomized controlled trials (RCTs) with prospective, parallel or crossover designs in humans in which the BACs effect was compared with that of placebo/control. Vascular homeostasis, blood pressure, endothelial function, oxidative stress and inflammatory biomarkers were considered primary outcomes. Results: We selected 26 articles, verifying their quality based on the Scottish Intercollegiate Guidelines Network, establishing diverse quality levels of scientific evidence according to the design and bias risk of a study. Grades of recommendation were included, depending on the evidence strength of antecedents. Conclusions: Evidence shows that certain BACs' derivative from active lipids and nitrogen compounds, mainly from horse chestnut seed extract, sterol plants, allium derivatives, and certain doses of beta-glucans, can be helpful in decreasing the prevalence of CVD risk factors. However, further rigorous evidence is necessary to support and prove BACs' effect on CVD prevention and treatment.

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Impact of Acute Caffeine Ingestion on Endothelial Function in Subjects With and Without Coronary Artery Disease

Cited by 67 publications

References 29 publications

A Rapid Method to Evaluate Cardiac Repolarization Changes: The Effect of Two Coffee Strengths on the QT Interval

A Rapid Method to Evaluate Cardiac Repolarization Changes: The Effect of Two Coffee Strengths on the QT Interval

Coffee with a high content of chlorogenic acids and low content of hydroxyhydroquinone improves postprandial endothelial dysfunction in patients with borderline and stage 1 hypertension

A Systematic Review of the Efficacy of Bioactive Compounds in Cardiovascular Disease: Carbohydrates, Active Lipids and Nitrogen Compounds

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