Impact of Acute and Chronic Hyperglycemia on In-Hospital Outcomes of Patients With Acute Myocardial Infarction

Fujino, Masashi; Ishihara, Masaharu; Honda, Satoshi; Kawakami, Shoji; Yamane, Takafumi; Nagai, Toshiyuki; Nakao, Kazuhiro; Kanaya, Tomoaki; Kumasaka, Leon; Asaumi, Yasuhide; Arakawa, Tetsuo; Terada, Yoshio; Nakanishi, Masayoshi; Noguchi, Teruo; Kusano, Kengo; Anzai, Toshihisa; Goto, Yoichi; Yasuda, Satoshi; Ogawa, Hisao

doi:10.1016/j.amjcard.2014.09.015

Cited by 38 publications

(39 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This observation could be interpreted according to the results of the study by Timmer et al [13], who showed that in patients without pre-hospital DM, after exclusion of early mortality (within 30 days), admission glycaemia lost its significant impact on long-term mortality, although this parameter was associated with larger infarct size. The association of acute hyperglycaemia with infarct size has been shown recently, especially in patients without evidence of chronic hyperglycaemia [14]. Those data correspond with observed differences in admission glycaemia and CK-MB levels between study groups.…”

Section: Discussionsupporting

confidence: 71%

Long-term prognosis is related to mid-term changes of glucometabolic status in patients with acute myocardial infarction treated invasively

et al. 2017

View full text Add to dashboard Cite

A b s t r a c tBackground: Glucometabolic status (GS) in patients with acute myocardial infarction (AMI) has an impact on prognosis, but it may change over time. Aim:To evaluate the prognosis after AMI treated invasively with respect to changes in GS assessed by oral glucose tolerance test at discharge and at mid-term follow-up visit (FU-visit).Methods: Glucometabolic status was assessed by two-hour post-load glycaemia and defined as abnormal glucose tolerance (AGT) or normal glucose tolerance (NGT). Out of 454 in-hospital AMI survivors, 368 (81%) patients completed an FU-visit and were divided into four groups with respect to GS at discharge and FU-visit: group 1 -AGT at discharge and FU-visit (n = 101); group 2 -AGT at discharge and NGT at FU-visit (n = 48); group 3 -NGT at discharge and AGT at FU-visit (n = 114); and group 4 -NGT at discharge and FU-visit (n = 105). All-cause mortality was compared between groups with log-rank test.Results: Median time from AMI to FU-visit was seven months. Median remote follow-up duration after AMI was 31 months. Two-hour post load glycaemia was significantly higher in patients with confirmed AGT at FU-visit than in other groups. Mortality was higher in group 1 (11.9%) than in group 2 (2.1%; p = 0.034) and group 4 (2.9%; p = 0.009). Mortality rates between group 2 and 4 were similar (2.1% vs. 2.9%; p = 0.781). There was no significant difference in mortality between group 1 and group 3 (11.9% vs. 6.1%; p = 0.114). Mortality in group 3 was over two-fold higher than in group 4; however, this difference was statistically non-significant (6.1% vs. 2.9%; p = 0.247). Conclusions:Prognosis for patients with confirmed AGT was unfavourable; however, patients with AGT at discharge, in whom GS improved, had similar mortality to subjects with persistent NGT. The major clinical implication from this study is the finding that reassessment of GS by repeated oral glucose tolerance test has significant prognostic value and makes initial risk stratification performed at discharge more reliable.

show abstract

Section: Discussionsupporting

confidence: 71%

Long-term prognosis is related to mid-term changes of glucometabolic status in patients with acute myocardial infarction treated invasively

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Malmberg et al reported that in STEMI patients stabilized by thrombolysis, hyperglycemia was associated with a higher mortality rate compared with euglycemic patients [5]. A Japanese study reported that hyperglycemia in patients with STEMI was associated with higher morbidity of large infarcts and higher in-hospital mortality compared with euglycemic patients [15]. STEMI outcomes in patients with T2DM can be improved after controlling blood glucose levels [16].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Value of Hyperglycemia on Admission on In-hospital Outcomes in Patients Presenting with ST-elevation Myocardial Infarction

Shahid¹,

Hma²,

Ms³

et al. 2020

Cureus

View full text Add to dashboard Cite

“…Interestingly, the same association with non-diabetics was also reported in a Japanese cohort of acute myocardial infarction patients. 16 A recently published meta-analysis also concluded that patients with new-onset hyper- Comparison of mean blood sugar levels (mg/dl) in discharged versus expired patients (t-test). Numbers in rows show (expired/total) patients in respective category.…”

Section: Discussionmentioning

confidence: 99%

Association of Hyperglycemia with In-Hospital Mortality in Septicemia

Afzal¹,

Khan²,

Ali³

et al. 2016

Annals KEMU

View full text Add to dashboard Cite

Objective: To document association of hyperglycemia with mortality in septicemic patients. Methods: After approval from departmental review committee, this retrospective comparative study was conducted from the chart review of 197 medical files of patients with primary diagnosis of bacterial sepsis admitted in a medical unit of department of Internal Medicine, King Edward Medical University Lahore from October 2012 to Septfember 2013. Sepsis was defined as by international sepsis definitions conference criteria 2001. "Diabetics" were evident from history; the term non-diabetic was used for the rest. Highest blood sugar value recorded during admission with Optium Xceed glucometer was used for analysis. Mean blood sugar of discharged and deceased patients were compared (t-test), mortality of diabetic and nondiabetic patients was compared by frequency of hyperglycemia (≥ 200 mg/dl) by chi-square test. SSPS version 20 was used. A p-value < 0.05 was considered significant.Results: Mean age of patients was 59.8 years, 92 (46.7%) males, and 105 (53.3%) were females. Mean blood sugar was high in known diabetics (314 ± 129 mg/dl), and non-diabetics (210 ± 109 mg/dl). Higher mean blood sugar was significantly associated with mortality in females (p = 0.032); trend towards significance was found in non-diabetic females (p = 0.065). Association of mortality in relation to hyperglycemia (Blood sugar ≥ 200 mg/dl), was found significant in whole study group (p = 0.038); sub-analysis revealed prominent association in non-diabetics (p = 0.027), and females (p = 0.04). Conclusion:Despite certain limitations of this study, hyperglycemia (blood sugar >200 mg/dl) may be a bad prognostic marker in septicemic non-diabetic female population; they need special attention for earlier and aggressive treatment.

show abstract

Impact of Acute and Chronic Hyperglycemia on In-Hospital Outcomes of Patients With Acute Myocardial Infarction

Cited by 38 publications

References 18 publications

Long-term prognosis is related to mid-term changes of glucometabolic status in patients with acute myocardial infarction treated invasively

Long-term prognosis is related to mid-term changes of glucometabolic status in patients with acute myocardial infarction treated invasively

Prognostic Value of Hyperglycemia on Admission on In-hospital Outcomes in Patients Presenting with ST-elevation Myocardial Infarction

Association of Hyperglycemia with In-Hospital Mortality in Septicemia

Contact Info

Product

Resources

About