Impact of Acute Alcohol Exposure on P‐Glycoprotein Function at the Blood‐Brain Barrier Assessed Using ¹¹C‐Metoclopramide PET Imaging

Response to “Impact of Acute Alcohol Exposure on P‐Glycoprotein Function at the Blood–Brain Barrier Assessed Using 11C‐Metoclopramide PET Imaging”

“…Auvity and Tournier used metoclopramide as an in vivo P‐glycoprotein (P‐gp) test substrate in baboons to assess the effect of ethanol on this carrier as a component of the blood–brain barrier (BBB). Their finding is unequivocal: ethanol at plasma concentrations of 0.5–1.0 g/L has no effect, whereas coadministration of tariquidar, used as a reference P‐gp inhibitor, drastically increased metoclopramide distribution to the brain.…”