Impact of Acacia bark extract tablets on the skin of healthy humans: a randomized, double-blind, placebo-controlled study

Abstract

This study investigated the effects of proanthocyanidins derived from Acacia (Acacia mearnsii) bark extract in healthy Japanese adult subjects experiencing uncomfortable skin symptoms. All subjects were randomly allocated into two groups (n = 33 each) using a computerized random-number generator. The subjects received either Acacia bark extract tablets or placebo for 8 weeks. Evaluations included water content in the stratum corneum, transepidermal water loss (TEWL), Skindex-16, dermatology life quality index (DLQI), visual analog scale for desire to scratch, and blood tests. At 4 weeks, the symptom/feeling score of DLQI, subjective symptoms related to uncomfortable skin, and the desire to scratch were significantly reduced in the intervention group than in the placebo group. At 8 weeks, the intervention group exhibited significantly lower TEWL on facial skin than that in the placebo group. In conclusion, the intake of Acacia bark extract tablets reduced TEWL and improved dry and uncomfortable skin.

Beneficial Effect of Heat-Killed Lactiplantibacillus plantarum L-137 on Skin Functions in Healthy Participants: A Randomized, Placebo-Controlled, Double-Blind Study

“…A French large-scale opinion poll demonstrated that the DLQI score was correlated with the severity of sensitive skin in that 80% of persons with sensitive skin declared that they had dry skin ( 47 ). Moreover, this study and another studies ( 48 ) also showed improvement of the DLQI score in parallel with the increase of the water content, and the satisfaction with the condition of the skin, which suggest that the DLQI could be an applicable questionnaire to investigate the effects of dry skin on health-related QOL even if in healthy subjects. Thus, improvement of dry skin by HK L-137 might increase people's satisfaction with the condition of their skin and health-related QOL.…”

Proanthocyanidins and Where to Find Them: A Meta-Analytic Approach to Investigate Their Chemistry, Biosynthesis, Distribution, and Effect on Human Health

“…Accordingly, of the 327 published full text articles that were identified during the bibliographic research, 319 were excluded. Data from the selected articles (n = 8) were employed for the meta-analysis [ 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 ]. Since data were accumulated from a series of studies that had been independently performed, all of the selected studies were not functionally equivalent.…”

“… Forest plot representation of the effects derived from the supplementation of PACs on hematic sugar levels. Data were extrapolated from [ 177 , 178 , 179 , 180 , 181 , 182 , 183 , 184 ], and plotted according to the mean difference. Each horizontal line of the plot represents an individual study, reporting the punctual result plotted as green box.…”

Effect of proanthocyanidins on blood lipids: A systematic review and meta‐analysis

“…Animal experiments have confirmed the benefit of PCs in regulating blood lipids (Li et al, 2019; Rodríguez‐Pérez et al, 2019; Rong et al, 2018). Moreover, several prospective studies (Anderson et al, 2015; Koutsos et al, 2020) and randomized controlled clinical trials (RCTs) (Aihong, 2011; Akazome et al, 2010; Baba et al, 2021; Baba, Natsume, et al, 2007; Baba, Osakabe, et al, 2007; Dianjuan, 2008; Giovannelli et al, 2011; Gupta et al, 2012; Hailin, 2018; Hollands et al, 2018; Hoshino et al, 2019; Jingru, 2012; Novotny et al, 2015; Rodriguez‐Mateos et al, 2018; Sano et al, 2007; Valls et al, 2016; Vigna et al, 2003) have investigated the effect of PCs on blood lipids in normal and mildly hyperlipidemic populations. Some RCTs have demonstrated the regulation of blood lipids by PCs (Baba, Natsume, et al, 2007; Baba, Osakabe, et al, 2007; Gupta et al, 2012; Novotny et al, 2015; Rodriguez‐Mateos et al, 2018; Sano et al, 2007; Valls et al, 2016), whereas others found no significant effect or the opposite effect (Akazome et al, 2010; Hoshino et al, 2019).…”