Impact of abdominal fat distribution, visceral fat, and subcutaneous fat on coronary plaque scores assessed by 320-row computed tomography coronary angiography

Tanaka, Tetsu; Kishi, Satoru; Ninomiya, Kai; Tomii, Daijiro; Koseki, Keita; Sato, Yu; Okuno, Taishi; Sato, Kei; Koike, Hideki; Yahagi, Kazuyuki; Komiyama, Kanki; Aoki, Jiro

doi:10.1016/j.atherosclerosis.2019.06.910

Cited by 25 publications

(24 citation statements)

References 32 publications

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“…The present study supports these findings. In addition, central fat distribution is now recognized as an important predictor and modifier of adverse health consequences, such as hypertension, insulin resistance, type 2 diabetes mellitus, dyslipidemia and coronary heart disease, through various mechanisms, although central fat distribution indicated by WC and VFA was not related to sedentary time in the present study. In contrast, PA was statistically related to both WC and VFA, but not to BMI.…”

Section: Discussioncontrasting

confidence: 58%

Impact of physical activity and sedentary time on glycated hemoglobin levels and body composition: Cross‐sectional study using outpatient clinical data of Japanese patients with type 2 diabetes

Nakanishi

Hirukawa

Shimoda

et al. 2019

J of Diabetes Invest

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Aims/Introduction: This study examined the association among sedentary time (ST), physical activity (PA), glycated hemoglobin and body composition in Japanese type 2 diabetes patients. Materials and Methods: Patients with type 2 diabetes who visited the outpatient clinic at Kawasaki Medical School Hospital, Okayama, Japan, comprised the study's participants. Self-administered International Physical Activity Questionnaire short forms were obtained and analyzed for 1,053 patients, including 158 patients for whom waist circumference and visceral fat accumulation were measured. From the questionnaire, three categorical data (low, moderate, high) and continuous data (METs/h/week) regarding PA and ST (min/day), respectively, were obtained. Results: The patients categorized as having low PA had significantly higher body mass index than those categorized as having high levels, after adjustment was made for confounders. Continuous data of PA were negatively associated with waist circumference and visceral fat accumulation. ST was positively associated with body mass index. After dividing the participants into four groups according to medians of ST and PA, the following categories were established: long ST and low PA, long ST but high PA, short ST but low PA and short ST and high PA. In terms of body mass index, short ST and high PA measured significantly lower than long ST and low PA. For waist circumference and visceral fat accumulation, short ST but low PA and short ST and high PA measured significantly lower than long ST and low PA and long ST but high. Conclusions: These results imply that the combination of avoiding sedentary behavior and increasing PA might be important in the prevention bodyweight gain and in the avoidance of central obesity, respectively, in Japanese type 2 diabetes patients.

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Section: Discussioncontrasting

confidence: 58%

Impact of physical activity and sedentary time on glycated hemoglobin levels and body composition: Cross‐sectional study using outpatient clinical data of Japanese patients with type 2 diabetes

Nakanishi

Hirukawa

Shimoda

et al. 2019

J of Diabetes Invest

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show abstract

“…In a recent publication by Tanaka et al, 11 they concluded that higher SFAT and lower VFAT inversely correlated with severity of coronary artery plaques in asymptomatic patients without history of CAD. Correspondingly, in a study by Otagiri, et al 12 it was found that visceral fat accumulation revealed by higher visceral fat/subcutaneous fat ratio could be a more important risk factor for severe CAD, unlike our observations.…”

Section: Discussionmentioning

confidence: 95%

V-FAT study – A correlation between novel markers of obesity and coronary artery disease severity assessed by Syntax score in patients presenting with acute coronary syndrome

Bahekar¹,

George

Jacob³

et al. 2020

Indian Heart Journal

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Our aim was to evaluate the role of traditional versus newer markers of obesity, in risk assessment of CAD. 50 consecutive ACS patients and 20 controls were enrolled.Visceral and Subcutaneous fat (VFAT and SFAT) analysis was done using multi-slice abdominal MRI. Syntax score was calculated from coronary angiogram. In our study, BMI and Waist/Hip ratios showed poor correlation with Syntax score. VFAT and SFAT showed strong correlation with Syntax score (p-0.01,0.03) and a more significant correlation was noted with their areas at L3-L4 levels (p-0.01,0.05). Statistically significant ROC- area under curve was observed with Indexed SFAT.

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“…Patients with more fat and less muscle mass have a worse prognosis after PCI [23]. Further, the higher the proportion of visceral fat, the higher the risk of CAD [24]. However, it is difficult to measure muscle mass and visceral fat mass in terms of burdens, such as time and cost, in routine examinations.…”

Section: Discussionmentioning

confidence: 99%

Impact of changes in body mass index after percutaneous coronary intervention on long-term outcomes in patients with coronary artery disease

et al. 2020

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Little is known about the impact of changes in body mass index (BMI) after the percutaneous coronary intervention (PCI) on long-term outcomes in patients with coronary artery disease (CAD). Therefore, this study aimed to clarify this issue. We investigated data on CAD obtained from the SHINANO Registry, a prospective, observational, multicenter cohort study, from 2012 to 2013 in Nagano, Japan. One year after PCI, the enrolled patients were divided into the following three groups based on changes in BMI by tertiles: reduced, maintained, and elevated BMI. The associations among the groups and the 4-year outcomes [major adverse cardiac events (MACEs), all-cause death, Q-wave myocardial infarction, and stroke] were examined. Five hundred seventy-two patients were divided into the reduced, maintained, and elevated BMI groups. Over the 4-year follow-up period, the cumulative incidence of MACEs was 10.5% (60 cases). In the Kaplan–Meier analysis, the incidence rates of MACE were significantly higher in the reduced BMI group than in the maintained and elevated BMI groups [17.7% versus (vs.) 7.3% vs. 9.0%, p = 0.004]. Multivariable cox regression analysis showed that the reduced group showed increased risks of MACEs (hazard ratio 2.15; 95% confidence interval 1.29–3.57; p = 0.003). The long-term clinical outcomes of patients with CAD who underwent PCI were affected by the reduction in BMI after PCI. Furthermore, the elevation of BMI after PCI was not a poor prognostic factor.

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Impact of abdominal fat distribution, visceral fat, and subcutaneous fat on coronary plaque scores assessed by 320-row computed tomography coronary angiography

Cited by 25 publications

References 32 publications

Impact of physical activity and sedentary time on glycated hemoglobin levels and body composition: Cross‐sectional study using outpatient clinical data of Japanese patients with type 2 diabetes

Impact of physical activity and sedentary time on glycated hemoglobin levels and body composition: Cross‐sectional study using outpatient clinical data of Japanese patients with type 2 diabetes

V-FAT study – A correlation between novel markers of obesity and coronary artery disease severity assessed by Syntax score in patients presenting with acute coronary syndrome

Impact of changes in body mass index after percutaneous coronary intervention on long-term outcomes in patients with coronary artery disease

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