Impact of a Usual Serving Size of Flavanol-Rich Cocoa Powder Ingested with a Diabetic-Suitable Meal on Postprandial Cardiometabolic Parameters in Type 2 Diabetics—A Randomized, Placebo-Controlled, Double-Blind Crossover Study

Rynarzewski, Janina; Dicks, Lisa; Zimmermann, Benno F.; Stoffel‐Wagner, Birgit; Ludwig, Norbert; Helfrich, Hans‐Peter; Ellinger, Sabine

doi:10.3390/nu11020417

Cited by 20 publications

(20 citation statements)

References 38 publications

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“…Likewise, the consumption of a decaffeinated green tea extract providing a daily dose of 856 mg of EGCG for 16 weeks produced a significant reduction in HOMA-IR index in type 2 diabetic individuals [63]. In contrast, other studies have found that the acute and the short-term consumption of cocoa flavonoids had no effect on insulin sensitivity in diabetic patients [64][65][66][67]. Thus, supplementation with silybin-beta-cyclodextrin for 6 months tended to decrease the insulin resistance (HOMA-IR) in patients with T2D (differences were not significant) [68].…”

Section: Effects Of Flavonoids On Insulin Signaling In T2dmentioning

confidence: 98%

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Ramos

2021

Cells

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Type 2 diabetes (T2D) and obesity are relevant worldwide chronic diseases. A common complication in both pathologies is the dysregulation of the insulin-signaling pathway that is crucial to maintain an accurate glucose homeostasis. Flavonoids are naturally occurring phenolic compounds abundant in fruits, vegetables and seeds. Rising evidence supports a role for the flavonoids against T2D and obesity, and at present, these compounds are considered as important potential chemopreventive agents. This review summarizes in vitro and in vivo studies providing data related to the effects of flavonoids and flavonoid-rich foods on the modulation of the insulin route during T2D and obesity. Notably, few human studies have evaluated the regulatory effect of these phenolic compounds at molecular level on the insulin pathway. In this context, it is also important to note that the mechanism of action for the flavonoids is not fully characterized and that a proper dosage to obtain a beneficial effect on health has not been defined yet. Further investigations will contribute to solve all these critical challenges and will enable the use of flavonoids to prevent, delay or support the treatment of T2D and obesity.

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Section: Effects Of Flavonoids On Insulin Signaling In T2dmentioning

confidence: 98%

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Ramos

2021

Cells

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“…HDL increased while the concentration of TC, LDL, TG, and hsCRP remained unchanged [ 92 ]. No effects could be observed after an acute supplementation of 2.5 g cacao powder (ACTICOA TM ; 40.4 mg EC) with a diabetic-suitable breakfast in hypertensive, overweight or obese subjects with T2D [ 93 ].…”

Section: Antidiabetic Effects Of Flavan-3-ols: Clinical Interventimentioning

confidence: 99%

Antidiabetic Effects of Flavan-3-ols and Their Microbial Metabolites

2020

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Diet is one of the pillars in the prevention and management of diabetes mellitus. Particularly, eating patterns characterized by a high consumption of foods such as fruits or vegetables and beverages such as coffee and tea could influence the development and progression of type 2 diabetes. Flavonoids, whose intake has been inversely associated with numerous negative health outcomes in the last few years, are a common constituent of these food items. Therefore, they could contribute to the observed positive effects of certain dietary habits in individuals with type 2 diabetes. Of all the different flavonoid subclasses, flavan-3-ols are consumed the most in the European region. However, a large proportion of the ingested flavan-3-ols is not absorbed. Therefore, the flavan-3-ols enter the large intestine where they become available to the colonic bacteria and are metabolized by the microbiota. For this reason, in addition to the parent compounds, the colonic metabolites of flavan-3-ols could take part in the prevention and management of diabetes. The aim of this review is to present the available literature on the effect of both the parent flavan-3-ol compounds found in different food sources as well as the specific microbial metabolites of diabetes in order to better understand their potential role in the prevention and treatment of the disease.

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“…The ingestion of FL-rich foods could have a significant potential for managing cardiovascular health [9][10][11] . Many intervention studies have suggested that the intake of FL results in beneficial alterations in the metabolism such as a significant decrease in plasma LDL with an increase in HDL 12,13 and rise in glucose tolerance [14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues Through Sympathetic Nerve Activation

Ishii¹,

Muta²,

Teshima³

et al. 2021

Preprint

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We previously found increases in uncoupling protein (Ucp)-1 transcription in brown adipose tissue (BAT) of mice following a single oral dose of flavan 3-ols (FL), a fraction of catechins and procyanidins. It was confirmed that these changes were totally reduced by co-treatment of adrenaline blockers. According to these previous results, FL possibly activates sympathetic nervous system (SNS). In this study, we confirmed the marked increase in urinary catecholamine (CA) s projecting SNS activity following a single dose of 50 mg/kg FL. In addition, we examined the impact of the repeated administration of 50 mg/kg FL for 14 days on adipose tissues in mice. In BAT, FL tended to increase the level of Ucp-1 along with thermogenic transcriptome factors, such as peroxisome proliferator-activated receptor γ coactivator (PGC)-1α and PR domain-containing (PRDM)1. Transcription of browning markers, such as CD137 and transmembrane protein (TMEM) 26 in addition to PGC-1α were increased in epididymal adipose (eWAT) by FL. A multilocular morphology with cell size reduction was shown in the inguinal adipose (iWAT), together with increasing the level of Ucp-1 following administration of FL. These results suggest that FL produces browning in adipose through activation of the SNS.

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Impact of a Usual Serving Size of Flavanol-Rich Cocoa Powder Ingested with a Diabetic-Suitable Meal on Postprandial Cardiometabolic Parameters in Type 2 Diabetics—A Randomized, Placebo-Controlled, Double-Blind Crossover Study

Cited by 20 publications

References 38 publications

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Dietary Flavonoids and Insulin Signaling in Diabetes and Obesity

Antidiabetic Effects of Flavan-3-ols and Their Microbial Metabolites

Repeated Oral Administration of Flavan-3-ols Induces Browning in Mice Adipose Tissues Through Sympathetic Nerve Activation

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