Impact of a twelve-year rotavirus vaccine program on acute diarrhea mortality and hospitalization in Brazil: 2006-2018

Jesus, Myrela Conceição Santos de; Santos, Victor Santana; Storti-Melo, Luciane Moreno; Souza, Carlos Dornels Freire de; Barreto, Íkaro Daniel de Carvalho; Paes, Marcelo Vitor Costa; Lima, Pedro F.; Bohland, Anna Klara; Berezin, Eitan Naaman; Machado, Ricardo Luiz Dantas; Cuevas, Luís E.; Gurgel, Ricardo Queiróz

doi:10.1080/14760584.2020.1775081

Cited by 13 publications

(12 citation statements)

References 37 publications

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“…Data showed a significant reduction in mortality associated with acute diarrheal disease (ADD) in the post-vaccination period (22–54%), in both infants aged less than 1 year and children aged less than 5 years [ 18 – 22 ]. The same trend was observed in the number of hospitalizations due to ADD, which decreased by 17–52%, and specifically for RV cases, by 59–81% [ 19 , 22 – 29 ].…”

Section: Introductionsupporting

confidence: 65%

“…Brazil was one of the first to include this vaccine in 2006, altogether with El Salvador, Mexico, Nicaragua, Panama, and Venezuela [ 1 ]. Since then, several publications in Brazil have estimated 17–52.5% of ADD hospitalizations averted and a 42.2% reduction in RV samples [ 19 , 23 , 27 , 29 ]. Panama followed the same trend, with a decrease of 22–37% in ADD hospitalizations among children < 5 years [ 18 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Rotavirus Vaccine Impact since Its Introduction in the National Immunization Program of Argentina

et al. 2022

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Introduction Rotavirus (RV) is the most common cause of childhood diarrhea. Argentina introduced RV vaccination in the National Immunization Program in January 2015. This study evaluates the impact of RV vaccine implementation on the burden of acute diarrheal disease (ADD) and RV positive cases, and hospitalizations among children in Argentina. Methods A counterfactual time-series analysis was performed. Data on ADD (2013–2018) and RV diarrhea (2012–2018) cases in children aged < 5 years were collected from the National Healthcare Surveillance System (clinical and laboratory data). Data on hospital discharges following ADD and RV diarrhea (2011–2017) were retrieved from the Health Statistics and Information Office. All data were classified by the age groups < 1 year, < 2 years, 2–5 years. Vaccine impact was defined as the difference between the predicted time trend (simulated using 2012–2014 data) and the actual post-vaccination data (2015–2018). Results A significant reduction of 22.1% of notified ADD cases and 15.4% of hospital discharges following ADD among children < 2 years was observed in the 3 years after RV vaccine implementation. Data also showed a significant decline of 54.0% and 59.4% of notified RV cases in children < 2 and < 1 years, respectively, and a reduction of 39.3% and 40.8% in RV hospital discharges for the same age groups. Conclusion This study shows a significant reduction in notified ADD cases and RV cases and hospital discharges following ADD and RV cases in children < 2 years after RV vaccine introduction in Argentina in 2015. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s40121-022-00709-6.

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Section: Introductionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 99%

Rotavirus Vaccine Impact since Its Introduction in the National Immunization Program of Argentina

et al. 2022

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“…Na fala de Santos et al (2020); Pereira; Nogueira (2020) as lesões por pressão (LPP) constituem um problema de saúde pública de grande magnitude, representando um importante agravo para pacientes acamados. As lesões por pressão não ameaçam a vida num primeiro momento, mas é um problema que acarreta um desconforto ao paciente, dificultando o retorno ao convívio familiar e aumentando a probabilidade de infecção com agentes patogênicos podendo levar à morte.…”

Section: Resultados E Discussõesunclassified

II Jornada Integrada da Faculdade Santa Maria

Oliveira¹,

Feitosa²,

Drumond³

et al. 2022

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INTRODUÇÃO:Enteroparasitose é o termo referente a um conjunto de doenças causadas por vermes e helmintos que têm manifestações assintomáticas e sintomáticas que vão de simples desconfortos até obstruções intestinais, podendo culminar em óbito. Segundo a Organização Mundial da Saúde, esse grupo de doenças é um dos principais problemas da saúde pública mundial por ser diretamente ligado ao ciclo da pobreza, que abrange majoritariamente pessoas de locais longínquos e que sofrem com a falta de saneamento, condições inadequadas de higiene, escassez de água potável, moradias precárias e dificuldade no acesso aos programas govermentais de saúde. Além de suasaltas taxas de infecção e número de vítimas, essas enfermidades aumentam a decorrência de anemias, retardos cognitivos, desnutrição, irritabilidade e piora nos quadros das próprias parasitoses. OBJETIVO: Analisar a relação entre condições de saneamento básico com enteroparasitoses em regiões periféricas dos estados de Alagoas, Amazonas e Piauí. METODOLOGIA: Tratase de um estudo retrospectivo de parasitas intestinais, de natureza essencialmente descritiva e quantitativa, cujos dados são obtidos através do LILACS, BVS e SciELO e tem por tema "Parasitas Intestinais". Esses dados são classificados de acordo com as seguintes variáveis: faixa etária, características de enfermagem, internação e maior prevalência desses parasitas na população.RESULTADOS E DISCUSSÕES: Com a análise dos artigos foi constatada a prevalência de parasitoses intestinais com relação a carência de medidas sanitárias, sendo as mais comuns dos casos a Ascaris Lumbricoides, Giardia Lamblia, Entamoeba Coli e Histolyca nessas regiões é explicito que as condições precárias de saneamento são fatores fortemente ligados para uma maior incidência de parasitoses intestinais, visto que pessoas que residem nessas áreas não possuem condições de higiene suficientes para impedir que as parasitoses se manifestam. Ademais, ainda é pautado as características de cada região e quais fatores presentes em cada uma pode ampliar o risco de contágio. CONSIDERAÇÕES FINAIS: É necessário entender tanto os ciclos dos parasitos quanto as características das comunidades atingidas por eles para aplicar e desenvolver novas estratégias de combate. Nota-se que locais mais distantes dos centros urbanos apresentam maior prevalência pela falta de infraestrutura e de acesso à saúde.

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“…Rotavirus vaccination has had a significant positive impact in the areas with the worst socioeconomic indicators in Brazil, accounting for a significant reduction in hospitalization for diarrhea and its mortality rates since 2006 [ 41 ]. However, the areas with the greatest vulnerability were also those most affected by the COVID-19 pandemic [ 40 ] and those who experienced a significant decline in HRV vaccination coverage in the pandemic years.…”

Section: Discussionmentioning

confidence: 99%

Change in Rotavirus Vaccine Coverage in Brazil from before (2015–2019) through the COVID-19 Pandemic Period (2020–2021)

Barros

Carmo

et al. 2023

Viruses

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During the COVID-19 pandemic, a reduction in vaccination coverage of children and adolescents was observed in several countries. The aim of this study was to assess the impact of the pandemic, in the first two years, on human rotavirus vaccine (HRV) coverage in Brazil compared with previous years. The number of doses of HRV administered in the period from January 2015 to December 2021 and its annual vaccination coverage were analyzed. The vaccination coverage decreased to 77.3% in 2020 and to 70.4% in 2021, substantially lower than the minimum that would be expected (89.2%); the decline was more pronounced in the second year of the pandemic despite the fact that in this period, the circulation restrictions were already less tight. Of the five Brazilian macro-regions, the northeast had the largest decline, and the south had the smallest impact on coverage. At the municipal level, less than half of the Brazilian municipalities managed to achieve vaccination coverage above 90% in either pandemic year. Although there was already a downward trend in coverage in the pre-pandemic years, the present study shows that the values recorded in 2020 and 2021 were significantly lower. Monitoring of vaccination coverage in the coming years should be carried out continuously in order to avoid a possible resurgence of rotavirus-induced diarrhea.

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Impact of a twelve-year rotavirus vaccine program on acute diarrhea mortality and hospitalization in Brazil: 2006-2018

Cited by 13 publications

References 37 publications

Rotavirus Vaccine Impact since Its Introduction in the National Immunization Program of Argentina

Rotavirus Vaccine Impact since Its Introduction in the National Immunization Program of Argentina

II Jornada Integrada da Faculdade Santa Maria

Change in Rotavirus Vaccine Coverage in Brazil from before (2015–2019) through the COVID-19 Pandemic Period (2020–2021)

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