Impact of a single perioperative dose of dexamethasone on the incidence of surgical site infections: A case–control study

Abstract

In this case-control study we could not detect any evidence for an increased risk for SSI after a single-dose of dexamethasone (4-8 mg) in gynecological patients.

Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting

“…Further studies should be done to focus on hyperglycemia and its possible clinically-relevant side effects (metabolic disturbances, wound infection) following the SAMBA-recommended 4mg dosing. Multiple recent studies have not demonstrated an increased incidence of surgical site infections when dexamethasone is used prophylactically for PONV prevention (Bolac et al, 2013; Eberhart et al, 2011; Gali et al, 2012). …”

Surgical Site Infections in Gynecology

“…48 Another factor that has been discussed is hyperoxygenation during surgery. 53 49,50 In terms of intraoperative and perioperative warming, both locally and systemically, there is some evidence that taking measures to keep intraoperative core temperature higher than 36˚C decreases the risk for developing an SSI, among other complications.…”

Effects of supplemental oxygen and dexamethasone on surgical site infection: a factorial randomized trial

“…29 In contrast, a case-control analysis reported that low-dose dexamethasone increases infection risk, 30 while another case-control study did not find an increased risk of SSI with a single dose of dexamethasone (4-8 mg) in gynaecological patients. 31 Finally, a retrospective study did not identify an increased risk of wound complications (cellulitis, superficial SSI, wound separation, and fascial dehiscence) when 4-12 mg of dexamethasone was used for PONV management in patients having endometrial cancer surgery. 32 There remains a paucity of data from patients in whom dexamethasone administration was randomly assigned and wound infections carefully evaluated.…”