Clinical diagnostics can be improved by faster and more accessible disease detection. Our laboratory has developed a point of service (POS) device capable of rapid, sensitive, automated and multiplexed biomarker detection using human saliva instead of other biofluids. In this article, we review the technology that led to the development of this POS device. This POS technology can advance clinical diagnostics by saving time due to faster diagnosis, saving money due to a shorter hospital stay and ultimately improving clinical care.