Impact of a pharmacist-led oral chemotherapy-monitoring program in patients with metastatic castrate-resistant prostate cancer

Patel, Jay; Holle, Lisa M.; Clément, Jessica; Bunz, Thomas J.; Niemann, Christopher; Chamberlin, Kevin W.

doi:10.1177/1078155215612541

Cited by 44 publications

(102 citation statements)

References 14 publications

(25 reference statements)

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“…Moreover, two studies reported a significant increase in medication adherence. All studies that measured other process indicators reported a significant improvement in knowledge‐attitude‐practice for chemotherapy, awareness and knowledge regarding blood pressure management and adherence to laboratory parameter monitoring following pharmacist interventions.…”

Section: Resultsmentioning

confidence: 99%

“…After reviewing the titles and abstracts, 617 records were excluded because they did not include a study of pharmacist interventions in adult patients with cancer; did not assess the impact of interventions; or included non‐ambulatory patients. The remaining 40 records were selected for full‐text examination, of which 11 met all the eligibility criteria and were included in this systematic review . The excluded studies and the reasons for their exclusion are detailed in Appendix 2.…”

Section: Resultsmentioning

confidence: 99%

“…All studies were published in English and reported between 2012 and 2016. Sample size ranged from 12 to 249 individuals, with most studies including sample sizes smaller than 100 individuals (n=7) . In most studies (n=10), the mean age of patients was >50 years, and an equal proportion of men and women was recruited.…”

Section: Resultsmentioning

confidence: 99%

“…Sample size ranged from 12 to 249 individuals, with most studies including sample sizes smaller than 100 individuals (n=7) . In most studies (n=10), the mean age of patients was >50 years, and an equal proportion of men and women was recruited. Genitourinary cancer (n=9) was the most evaluated cancer type in this review, followed by gastrointestinal (n=5), breast (n=5), lung (n=5) and haematological cancer (n=3) .…”

Section: Resultsmentioning

confidence: 99%

“…Only six studies included a control group that received usual care (eg, prescription analysis or supply of medicines). The most commonly measured outcomes were rates of nausea and vomiting control (n=4) and patient satisfaction (n=3), followed by quality of life (n=2), adverse drug reaction or adverse event frequency (n=2), drug‐related problem frequency (n=1) and anti‐emesis drug costs (n=1) .…”

Section: Resultsmentioning

confidence: 99%

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The effects of pharmacist interventions on adult outpatients with cancer: A systematic review

et al. 2017

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SummaryWhat is known and objectives: Most antineoplastic drugs are highly toxic and have low therapeutic indexes, which can result in drug-related problems. In this context, pharmacist interventions may play an important role in the success of the treatment.The objective of this study was to examine the effects of pharmacist interventions on adult outpatients with cancer using antineoplastic drugs. Methods:A literature search was performed using PubMed, ISI Web of Science and LILACS databases from January 1990 to April 2016, using MeSH terms or text words related to pharmacist interventions, cancer and outpatient care. Studies published in English, Portuguese or Spanish on the effects of pharmacist interventions in outcome measures in adult outpatients with cancer were included. Two independent authors performed study selection and data extraction with a consensus process. The articles were analysed according to previously established criteria, such as country, study design, setting, population, type of cancer, description of the intervention and control groups, outcomes, main conclusions and study limitations. Results and discussion:A total of 874 records were identified, of which 11 satisfied the inclusion criteria. The studies were conducted mainly in the United States and included patients aged >50 years. Most studies had a before-after design. Pharmacist interventions primarily included educating and counselling patients on the management of adverse events. Rates of nausea and vomiting control, medication adherence and patient satisfaction were the most common outcome measures; a significant benefit in these parameters as a result of pharmacist interventions was noted in most studies. What is new and conclusion:The findings from this systematic review indicate that pharmacist interventions can improve outcome measures in outpatients with cancer.However, the collective quality of the studies was poor and gaps identified indicate that further research is needed to provide more robust results. K E Y W O R D Scancer, pharmaceutical care, pharmacists, systematic review

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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The effects of pharmacist interventions on adult outpatients with cancer: A systematic review

et al. 2017

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Ambulatory care hematology/oncology pharmacy services: A comprehensive review by the Saudi Oncology Pharmacy Assembly

Alsuhebany,

Alkhudair,

Alzahrani

et al. 2024

J Am Coll Clin Pharm

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Saudi Vision 2030 has driven significant changes in ambulatory care pharmacy services in the Kingdom of Saudi Arabia (KSA), transitioning pharmaceutical care from inpatient to outpatient settings. With a growing need to address non‐communicable diseases, particularly cancer, ambulatory care oncology pharmacy services are of paramount importance. This study aims to evaluate the potential benefits and challenges of establishing such services in the KSA and offers recommendations for clinical pharmacists. A comprehensive literature search was conducted using PubMed, MEDLINE, EMBASE, and Google Scholar, encompassing research from inception to September 2023. The search focused on English language studies related to ambulatory care oncology/hematology pharmacy services. Among the 1351 studies found, those assessing the impact of clinical pharmacists on patient outcomes in outpatient oncology clinics were included. The review of the literature highlights the substantial impact of clinical pharmacists in outpatient hematology/oncology settings. A selection of several studies revealed their role in improving patient care, reducing health care costs, and enhancing treatment outcomes. Notable findings include a high acceptance rate of pharmacist interventions with significant cost savings, increased pharmacist involvement in patient encounters, and reduced emergency department visits and inpatient admissions due to pharmacist interventions. These results showed the valuable contributions of clinical pharmacists in the international outpatient oncology setting. Establishing ambulatory care hematology/oncology pharmacy services in Saudi Arabia is critical, considering the rising cancer burden. The value of specialized oncology clinical pharmacists in the outpatient setting is emphasized by various studies conducted in the United States. This review proposes a framework for patient‐centered oncology practices, serving as a valuable resource for the strategic development of ambulatory care oncology pharmacy services in Saudi Arabia. These efforts align with Saudi Vision 2030's broader goals of enhancing health care quality and patient care.

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Implementation and evaluation of a pharmacist‐led oral anticancer medication management clinic

Byrne

Redmayne

Lam

et al. 2018

Pharmacy Practice and Res

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Background Oral anticancer medication (OAM) use is increasing in prevalence. Although OAM offers many advantages to patients, there is also a high risk of medication errors. Aim This study aimed to evaluate whether a pharmacist‐led OAM management clinic would improve patient understanding and adherence to OAMs and reduce medication errors. Methods Patients commencing OAM in the Oncology Outpatient Clinic between July 2015 and April 2016 were eligible for the study. OAM understanding was evaluated using a patient survey before and after initial pharmacist review, in the middle of the first cycle and prior to the second cycle. Education and symptom management advice were provided, as well as referral if required. Pharmacist interventions were documented, then independently assigned a significance rating by a medical officer and pharmacist. Local community pharmacists were approached to complete a survey investigating their practices and confidence dispensing OAMs. Results In all, 29 patients participated in the clinic. Survey results before and after initial pharmacist review showed a trend towards improved patient understanding, which was maintained mid‐cycle and before the second cycle. In addition, 51 pharmacist interventions were recorded: one of high, 32 of moderate and 18 of minimal clinical significance. Self‐reported adherence mid‐cycle and before the second cycle found that 1/18 and 1/9 patients, respectively, forgot to take a dose of their OAM and that 3/18 and 1/9 patients, respectively, reported not taking a dose for other reasons. The community pharmacist survey revealed that 40 and 50% were confident educating patients about OAM dosage regimens and side effects, respectively. Conclusion Although the significance of the pharmacists’ education and interventions cannot be determined because of the small sample size, a valuable service was implemented to meet patient needs and expectations.

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Impact of a pharmacist-led oral chemotherapy-monitoring program in patients with metastatic castrate-resistant prostate cancer

Abstract: These results suggest a potential opportunity exists to maximize oral chemotherapy treatment outcomes with the addition of a formalized monitoring program directed by an oncology pharmacist.

Cited by 44 publications

References 14 publications

The effects of pharmacist interventions on adult outpatients with cancer: A systematic review

The effects of pharmacist interventions on adult outpatients with cancer: A systematic review

Ambulatory care hematology/oncology pharmacy services: A comprehensive review by the Saudi Oncology Pharmacy Assembly

Implementation and evaluation of a pharmacist‐led oral anticancer medication management clinic

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