Impact of a novel ultrasound microvascular imaging and elastography on prostate cancer classification

Abstract

Background: This study was aimed to compare the sensitivity of transrectal ultrasound (TRUS) guided systematic biopsy (TRUS-SB), superb microvascular imaging guided targeted biopsy (SMI-TB), and elastography ultrasound guided targeted biopsy (EU-TB) in detecting prostate cancer (PCa).Methods: One hundred and eighty-four patients with suspicious PCa were randomly divided into two groups, SMI-TB group (n=92) and EU-TB group (n=92). All the patients received a 2-core SMI-TB or a 2-core EU-TB before receiving a 12-core TRU-SB depending on the group. The 2-core SMI-TB was conducted at the most increased vascularity areas rated by a radiologist on a semi-quantitative criterion. The 2-core EU-TB was performed at the dark blue areas that identified as suspicious areas. The PCa detection rate was compared among TRUS-SB, SMI-TB, and EU-TB in the total population and in two groups. Results: PCa was detected in 65 out of 184 patients. The SMI-TB group patients received 1,272 cores in total with a positive rate of 23.81% (40/168) for SMI-TB cores and 4.17% (46/1,104) for TRUS-SB cores. The EU-TB group patients received a total of 1,262 cores with a positive rate of 31.01% (49/158) for EU-TB cores and 5.34% (59/1,104) for TRUS-SB cores. Targeted cores (27.30%, 89/326) achieved significantly higher sensitivity in PCa detection than systematic cores (4.76%, 105/2,208) (SMI-TB vs. TRUS-SB: OR 7.188, P<0.001; EU-TB vs. TRUS-SB: OR 7.962, P<0.001).Conclusions: Superb microvascular imaging and elastography ultrasound guided targeted biopsy may result in higher prostate cancer detection rate as adjunct to gray-scale ultrasound guided systematic biopsy.However, targeted biopsy alone is not sufficient to detect PCa, compared with systematic biopsy.

Intraoperative shear-wave elastography and superb microvascular imaging contribute to the glioma grading

“…SMI is an innovative Doppler technology that can display low-velocity vessels and describe diseased microvessels in more detail than traditional CDFI. SMI is a safe and low-cost alternative to CEUS, which has been widely used in the thyroid, breast, prostate, uterine appendages, etc (34)(35)(36)(37)(38)(39). Our study applied SMI to distinguish between HGG and LGG and found different vascularity patterns in intratumoral and peritumoral tissues.…”

Modified Predictive Model and Nomogram by Incorporating Prebiopsy Biparametric Magnetic Resonance Imaging With Clinical Indicators for Prostate Biopsy Decision Making

“…However, decades of clinical experience have shown that PSA is not ideal in terms of specificity, often leading to either overdiagnosis or overtreatment (4)(5)(6). Prostate biopsy is the most valuable method in the diagnosis of PCa (7,8). Although preoperative preparation is actively improved, hemospermia, hematuria, and urinary tract infection are still the main adverse effects (9).…”

Using the Superb Microvascular Imaging Method in the Distinction of Intraductal Papilloma and Duct Ectasia With Secretion

“…Whereas filtering methods of conventional Doppler imaging suppress overlapping low‐velocity flow signals, noise and low‐velocity flow signals can be distinguished thanks to the adaptive filtering method used in SMI 12 . Therefore, it can be used for musculoskeletal, hepatobiliary, genitourinary, pediatric, and cardiovascular imaging as well as in differentiation breast lesions 12–17 . In this study, we investigated SMI in the visualization of the microvascular bed and intravascularization pattern of IDPs smaller than 1 cm.…”

“…12 Therefore, it can be used for musculoskeletal, hepatobiliary, genitourinary, pediatric, and cardiovascular imaging as well as in differentiation breast lesions. [12][13][14][15][16][17] In this study, we investigated SMI in the visualization of the microvascular bed and intravascularization pattern of IDPs smaller than 1 cm. We aimed to reveal the ability of SMI to distinguish IDP and duct ectasia with secretion.…”