Impact of a Novel Smartphone App (CureApp Smoking Cessation) on Nicotine Dependence: Prospective Single-Arm Interventional Pilot Study

Masaki, Katsunori; Tateno, Hiroki; Kameyama, Naofumi; Morino, Eriko; Watanabe, Riri; Sekine, Kazuma; Ono, Tomohiro; Satake, Kohta; Suzuki, Shin; Nomura, Akihiro; Betsuyaku, Tomoko; Fukunaga, Koichi

doi:10.2196/12694

Cited by 46 publications

(81 citation statements)

References 27 publications

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“…It consists of a CASC smartphone app for patients with nicotine dependence, a web-based patient management PC software for primary physicians, and a mobile exhaled CO checker. In a previous pilot study, we demonstrated that a prototype of the CASC smartphone app used together with a standard smoking cessation program yielded a higher CAR from weeks 9 to 24 compared with data from a Japanese national survey 7,8,21 .…”

Section: Introductionmentioning

confidence: 84%

A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker

et al. 2020

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Evidence of the long-term efficacy of digital therapies for smoking cessation that include a smartphone application (app) is limited. In this multi-center randomized controlled trial, we tested the efficacy of a novel digital therapy for smoking cessation: the "CureApp Smoking Cessation (CASC)" system, including a CASC smartphone app, a web-based patient management PC software for primary physicians, and a mobile exhaled carbon monoxide (CO) checker. A total of 584 participants with nicotine dependence were recruited from October 2017 to January 2018, and allocated 1:1 to the CASC intervention group or the control group. Both groups received a standard smoking cessation treatment with pharmacotherapy and counseling for 12 weeks. Meanwhile, the intervention group used the CASC system, and the control group used a control-app without a mobile CO checker, each for 24 weeks. The primary outcome was the biochemically validated continuous abstinence rate (CAR) from weeks 9 to 24. The main secondary outcome was an extended CAR from weeks 9 to 52. Except for 12 participants who did not download or use the apps, 285 participants were assigned to the intervention group, and 287, to the control. CAR from weeks 9 to 24 in the intervention group was significantly higher than that in the control group (63.9% vs. 50.5%; odds ratio [OR], 1.73; 95% confidence interval [CI], 1.24 to 2.42; P = 0.001). The CAR from weeks 9 to 52 was also higher in the intervention group than that in the control group (52.3% vs. 41.5%; OR, 1.55; 95% CI, 1.11 to 2.16; P = 0.010). No specific adverse events caused by the CASC system were reported. Augmenting standard face-to-face counseling and pharmacotherapy with a novel smartphone app, the CASC system significantly improved long-term CARs compared to standard treatment and a minimally supportive control app.

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Section: Introductionmentioning

confidence: 84%

A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker

et al. 2020

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“…It also provides professional online mentoring and offers nicotine replacement therapy (over-the-counter medical patches) delivered to the patient’s home. The ascure smartphone app was developed based on research with the CureApp Smoking Cessation app [ 10 - 12 ]. App users have access to tailored guidance in a timely fashion through daily use.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of the Ascure Smoking Cessation Program: Retrospective Study

Kato¹,

Tanigawa²,

Satake³

et al. 2020

JMIR Mhealth Uhealth

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Background Smoking cessation helps extend a healthy life span and reduces medical expenses. However, the standard 12-week smoking cessation program in Japan has several notable problems. First, only 30% of participants complete this program. Second, participants may choose not to participate unless they have a strong motivation to quit smoking, such as health problems. Third, the program does not provide enough support during the period between clinical visits and after 12 weeks. Objective This study examined the efficacy of the 24-week ascure program to address the problems of accessibility and continuous support. The program combines online mentoring, over-the-counter pharmacotherapy, and a smartphone app. Methods Using a retrospective study design, we investigated data for 177 adult smokers who were enrolled in the ascure smoking cessation program between August 2017 and August 2018. The primary outcomes were continuous abstinence rates (CARs) during weeks 9-12 and weeks 21-24. To confirm smoking status, we performed salivary cotinine testing at weeks 12 and 24. We also evaluated the program adherence rate. Finally, we performed exploratory analysis to determine the factors associated with continuous abstinence at weeks 21-24 to provide insights for assisting with long-term continuous abstinence. Results The CARs of all participants for weeks 9-12 and weeks 21-24 were 48.6% (95% CI 41.2-56.0) and 47.5% (95% CI 40.0-54.8), respectively. Program adherence rates were relatively high throughout (72% at week 12 and 60% at week 24). In the analysis of the factors related to the CAR at weeks 21-24, the number of entries in the app’s digital diary and number of educational videos watched during the first 12 weeks were significant factors. Conclusions The ascure program achieved favorable CARs, and participants showed high adherence. Proactive usage of the smartphone app may help contribute to smoking cessation success in the long-term.

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“…The medical theory, the epidemiological data, the psychotherapeutic aspects, and the user's needs were involved in developing theses apps (63,64). The apps permit the patient to keep a diary of the symptoms associated with quitting, the quantification of the achievements the addict accumulates during the therapy and especially after, and the online psychotherapeutic characteristics (65). The interactive nature of these applications showed increased patient compliance after NRT therapy, with potential value for such programs either as complementary or as a sequence in smoking cessation programs (66).…”

Section: Treatment Strategy In Nicotine Addictionmentioning

confidence: 99%

Insights into the pathogenesis of nicotine addiction. Could a salivary biosensor be useful in Nicotine Replacement Therapy (NRT)?

Băbțan¹,

Petrescu²,

Ionel³

et al. 2019

JMMS

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Nicotine has gained the attention of the medical community due to its insidious addictive mechanisms which lead to chronic consumption. The multitude of compounds derived from tobacco smoke have local and systemic negative impacts, resulting in a large number of smoking-related pathologies. The present review offers insights into nicotine addiction physiopathology, as well as social and medical implications, with emphasis on its correlation with Advanced Glycation End Products (AGEs). Therapeutic strategies and new approaches to nicotine assessment and cessation treatment are discussed, noting that such strategies could take into account the possibility of slow and gradual nicotine release from a device attached to a prosthetic piece, based on salivary nicotine-concentration feedback. This approach could offer real-time and home-based self-therapy monitoring by the physician and the patient for follow-up and improve long-term cessation treatment success-Graphical abstract.

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Impact of a Novel Smartphone App (CureApp Smoking Cessation) on Nicotine Dependence: Prospective Single-Arm Interventional Pilot Study

Cited by 46 publications

References 27 publications

A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker

A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker

Efficacy of the Ascure Smoking Cessation Program: Retrospective Study

Insights into the pathogenesis of nicotine addiction. Could a salivary biosensor be useful in Nicotine Replacement Therapy (NRT)?

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